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pro vyhledávání: '"Michael D. Weller"'
Autor:
Michael D. Weller, Nigel S. Simpkins
Publikováno v:
Tetrahedron Letters. 51:4823-4826
The tricyclic natural products ialibinone A and ialibinone B were prepared as a 41:59 mixture in four steps starting from phloroglucinol. The synthetic sequence involved (i) acylation of phloroglucinol under Friedel–Crafts conditions, (ii) double p
Autor:
Nigel S. Simpkins, Michael D. Weller
Publikováno v:
Stereochemical Aspects of Organolithium Compounds
Publikováno v:
The Journal of Organic Chemistry. 74:7898-7907
A two-directional synthesis of a masked hexayne 7, in which two beta-chlorovinylsilanes protect two of the internal alkynes, is reported. The key step involves the Pd-catalyzed oxidative dimerization of alkyne 10 to provide diyne 12, which is elabora
Autor:
Liam R. Cox, Michael D. Weller
Publikováno v:
Comptes Rendus Chimie. 12:366-377
This article summarises our recent efforts towards using β-halovinylsilanes in a new approach to oligoyne assembly. β-Halovinylsilanes are particularly useful masked alkynes since the free alkyne can be released under mild reaction conditions by tr
Publikováno v:
Tetrahedron Letters. 49:4596-4600
A stereoselective halodestannylation of (E)-β-stannylvinylsilane 6 has been used to access a range of (E)-β-halovinylsilanes. Most notably, the β-fluorovinylsilane 14 was accessed in high yield using the Selectfluor® reagent, and subsequently con
Autor:
Michael D. Weller, Nigel S. Simpkins
Publikováno v:
ChemInform. 45
Lithium dialkylamides, especially lithium diisopropylamide (LDA), are valuable bases in organic synthesis but it is only since 1980 that their chiral counterparts have found application in reactions that can be broadly defined as asymmetric deprotona
Publikováno v:
ChemInform. 44
Publikováno v:
Organicbiomolecular chemistry. 11(30)
A strategy for the synthesis of members of the prenylated indole alkaloid family is described, which involves a radical cascade process of an appropriately substituted diketopiperazine (DKP) core structure. Several approaches to the generation of the
Autor:
Nigel S. Simpkins, Michael D. Weller
Publikováno v:
Organic Reactions
Lithium dialkylamides, especially lithium diisopropylamide (LDA), are valuable bases in organic synthesis but it is only since 1980 that their chiral counterparts have found application in reactions that can be broadly defined as asymmetric deprotona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::448912a510f8b6d1d39f91196742559d
https://doi.org/10.1002/0471264180.or079.02
https://doi.org/10.1002/0471264180.or079.02
Autor:
Michael D. Weller, Liam R. Cox
Publikováno v:
ChemInform. 41
This article summarises our recent efforts towards using β-halovinylsilanes in a new approach to oligoyne assembly. β-Halovinylsilanes are particularly useful masked alkynes since the free alkyne can be released under mild reaction conditions by tr