Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Michael D. Walker"'
Autor:
Jonathan Sobel, Claudiane Guay, Ofer Elhanani, Adriana Rodriguez-Trejo, Lisa Stoll, Véronique Menoud, Cécile Jacovetti, Michael D. Walker, Romano Regazzi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is preceded by a phase of intense proliferation. These events occurring in the neonatal period are decisive for establishing an appropriate functio
Externí odkaz:
https://doaj.org/article/b8ebcf5f93ea4a368630185da5395111
Autor:
Kfir Molakandov, Denise A. Berti, Avital Beck, Ofer Elhanani, Michael D. Walker, Yoav Soen, Karina Yavriyants, Michal Zimerman, Ella Volman, Itzik Toledo, Anna Erukhimovich, Alon M. Levy, Arik Hasson, Joseph Itskovitz-Eldor, Judith Chebath, Michel Revel
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundCell therapy of diabetes aims at restoring the physiological control of blood glucose by transplantation of functional pancreatic islet cells. A potentially unlimited source of cells for such transplantations would be islet cells derived fr
Externí odkaz:
https://doaj.org/article/08ac132b6b464d948e28e8475b2b0b11
Autor:
Ofer Elhanani, Michael D. Walker
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100096- (2020)
Summary: The potential of reprogrammed β cells derived from pancreatic exocrine cells to treat diabetes has been demonstrated in animal models. However, the precise mechanisms and regulators involved in this process are not clear. Here, we describe
Externí odkaz:
https://doaj.org/article/e9c7507a0727403ebf4c976ef4e715f2
Autor:
Ofer Elhanani, Tomer Meir Salame, Jonathan Sobel, Dena Leshkowitz, Lital Povodovski, Itay Vaknin, Dror Kolodkin-Gal, Michael D. Walker
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of
Externí odkaz:
https://doaj.org/article/d8304aed690945eb9d1ebe06d45b0285
Autor:
Jonathan, Sobel, Claudiane, Guay, Ofer, Elhanani, Adriana, Rodriguez-Trejo, Lisa, Stoll, Véronique, Menoud, Cécile, Jacovetti, Michael D, Walker, Romano, Regazzi
Publikováno v:
Scientific reports, vol. 11, no. 1, pp. 8800
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is preceded by a phase of intense proliferation. These events occurring in the neonatal period are decisive for establishing an appropriate functional β-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8b6bbc3bb11046c31a3b45a79dc60d70
https://serval.unil.ch/notice/serval:BIB_8A32EB66F140
https://serval.unil.ch/notice/serval:BIB_8A32EB66F140
Autor:
Michael D. Walker, Ofer Elhanani
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100096-(2020)
STAR Protocols
STAR Protocols
Summary The potential of reprogrammed β cells derived from pancreatic exocrine cells to treat diabetes has been demonstrated in animal models. However, the precise mechanisms and regulators involved in this process are not clear. Here, we describe a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcab7618a9f25d9e1e01bd4b20c2aeff
http://www.sciencedirect.com/science/article/pii/S2666166720300836
http://www.sciencedirect.com/science/article/pii/S2666166720300836
Autor:
Kfir Molakandov, Ella Volman, Michael D. Walker, Yoav Soen, Anna Eruhimovich, Alon Levy, Arik Hasson, Karina Yavriyants, Yitzhak Toledo, Avital Beck, Michal Zimerman, Judith Chebath, Joseph Itskovitz-Eldor, Denise Aparecida Berti, Michel Revel, Ofer Elhanani
BackgroundCell therapy of diabetes aims at restoring the physiological control of blood glucose by transplantation of functional pancreatic islet cells. Human islets from post-mortem donations have shown efficiency but the demand for islets vastly ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e48f84b218c9e14b65872e37d4fe84
https://doi.org/10.21203/rs.3.rs-23915/v1
https://doi.org/10.21203/rs.3.rs-23915/v1
Autor:
Dror Kolodkin-Gal, Dena Leshkowitz, Lital Povodovski, Ofer Elhanani, Itay Vaknin, Jonathan Sobel, Michael D. Walker, Tomer-Meir Salame
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp-(2020)
Summary The emerging appreciation of plasticity among pancreatic lineages has created interest in harnessing cellular reprogramming for β cell replacement therapy of diabetes. Current reprogramming methodologies are inefficient, largely because of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efbe145f4b34ae8c5e8442f725f0fe0
https://pubmed.ncbi.nlm.nih.gov/32375045
https://pubmed.ncbi.nlm.nih.gov/32375045
Publikováno v:
Toxicology and Applied Pharmacology. 384:114782
Bleomycin is an anticancer antibiotic effective against a range of human malignancies. Yet its usefulness is limited by serious side effects. In this study, we converted bleomycin into a prodrug by covalently linking 2-sulfo, 9 fluorenylmethoxycarbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e72fc5ccc1035554cb9cd59e00a96a
https://doi.org/10.1016/j.taap.2019.114782
https://doi.org/10.1016/j.taap.2019.114782
Autor:
Dylan M. Rausch, Gregory W. Carter, Hui Tian, Bo Ji, Michael D. Walker, Christopher L. Baker, Catrina Spruce, Petko M. Petkov, Kenneth Paigen, Kwangbom Choi, Seda Arat, Natalie R. Powers, Pavlina Petkova, Guruprasad Ananda
While much is known about the enzymes that deposit and remove epigenetic modifications, less is known about the trans-acting system that determines when and where these modifications occur. By looking at four diverse... The epigenetic landscape varie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e428393ac7e3a46c33e523c6cefc569
https://doi.org/10.1101/322081
https://doi.org/10.1101/322081