Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Michael D. Uhler"'
Autor:
Mark L. Schultz, Kylie J. Schache, Ruth D. Azaria, Esmée Q. Kuiper, Steven Erwood, Evgueni A. Ivakine, Nicole Y. Farhat, Forbes D. Porter, Koralege C. Pathmasiri, Stephanie M. Cologna, Michael D. Uhler, Andrew P. Lieberman
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
The folding and trafficking of transmembrane glycoproteins are essential for cellular homeostasis and are compromised in many diseases. In Niemann-Pick type C disease, a lysosomal disorder characterized by impaired intracellular cholesterol trafficki
Externí odkaz:
https://doaj.org/article/2bc188a944d2407a91abc2701d466d6c
Autor:
Andrew M. Tidball, Louis T. Dang, Trevor W. Glenn, Emma G. Kilbane, Daniel J. Klarr, Joshua L. Margolis, Michael D. Uhler, Jack M. Parent
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 725-731 (2017)
Specifically ablating genes in human induced pluripotent stem cells (iPSCs) allows for studies of gene function as well as disease mechanisms in disorders caused by loss-of-function (LOF) mutations. While techniques exist for engineering such lines,
Externí odkaz:
https://doaj.org/article/5242b95b4a4946f5a8fdb5aab5823ec7
Autor:
Sarah U. Morton, Christopher R. Sefton, Huanqing Zhang, Manhong Dai, David L. Turner, Michael D. Uhler, Pankaj B. Agrawal
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2692 (2021)
microRNAs (miRNAs) regulate messenger RNA (mRNA) abundance and translation during key developmental processes including muscle differentiation. Assessment of miRNA targets can provide insight into muscle biology and gene expression profiles altered b
Externí odkaz:
https://doaj.org/article/80a300f3c70948b381fed1d5c076024d
Autor:
Joshua L. Margolis, Andrew M. Tidball, Emma G. Kilbane, Louis T. Dang, Daniel J. Klarr, Jack M. Parent, Trevor Glenn, Michael D. Uhler
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 3, Pp 725-731 (2017)
Stem Cell Reports, Vol 9, Iss 3, Pp 725-731 (2017)
Summary Specifically ablating genes in human induced pluripotent stem cells (iPSCs) allows for studies of gene function as well as disease mechanisms in disorders caused by loss-of-function (LOF) mutations. While techniques exist for engineering such
Autor:
Christopher Sefton, Manhong Dai, Huanqing Zhang, Pankaj B. Agrawal, Sarah U. Morton, David L. Turner, Michael D. Uhler
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2692, p 2692 (2021)
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2692, p 2692 (2021)
microRNAs (miRNAs) regulate messenger RNA (mRNA) abundance and translation during key developmental processes including muscle differentiation. Assessment of miRNA targets can provide insight into muscle biology and gene expression profiles altered b
Autor:
Frank J. Gonzalez, Sarvesh Periyasamy, Kevin Weisz, Yatrik M. Shah, Brook Centofanti, Shogo Takahashi, Michael D. Uhler, Huabing Zhang, Zheng Chen, Sadeesh K. Ramakrishnan, Liangyou Rui
Publikováno v:
Cell Metabolism. 23(3):505-516
Glucagon drives hepatic gluconeogenesis and maintains blood glucose levels during fasting. The mechanism that attenuates glucagon action following refeeding is not understood. The present study demonstrates an increase in perivenous liver hypoxia imm
Autor:
Michael D. Uhler, Shweta Gupta, Fan Meng, Huda Akil, Stanley J. Watson, Andrew M. Tidball, Jack M. Parent, Tanya M‐Redmond
Publikováno v:
Journal of neurochemistry. 145(3)
Many neuropsychiatric disorders are thought to result from subtle changes in neural circuit formation. We used human embryonic stem cells and induced pluripotent stem cells (hiPSCs) to model mature, post-mitotic excitatory neurons and examine effects
Autor:
David L. Turner, Michael D. Uhler, Shweta Gupta, Holly S. Huang, Tanya M. Redmond, Ginger Kubish, Robert C. Thompson
Publikováno v:
Journal of Molecular Neuroscience. 55:684-705
As members of the proneural basic-helix-loop-helix (bHLH) family of transcription factors, Ascl1 and Neurog2 direct the differentiation of specific populations of neurons at various times and locations within the developing nervous system. In order t
Publikováno v:
Developmental Biology. 361:103-115
Regulated proliferation and cell cycle exit are essential aspects of neurogenesis. The Yap transcriptional coactivator controls proliferation in a variety of tissues during development, and this activity is negatively regulated by kinases in the Hipp
Autor:
Ginger M. Kubish, Tanya M. Redmond, David L. Turner, Michael D. Uhler, Robert C. Thompson, Holly S. Huang, Geoffrey G. Murphy
Publikováno v:
Molecular and Cellular Neuroscience. 44:282-296
The basic helix-loop-helix transcription factor Ascl1 plays a critical role in the intrinsic genetic program responsible for neuronal differentiation. Here, we describe a novel model system of P19 embryonic carcinoma cells with doxycycline-inducible