Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael D. Tyka"'
Publikováno v:
Limnology and Oceanography Letters, Vol 8, Iss 5, Pp 685-691 (2023)
Externí odkaz:
https://doaj.org/article/65f9b28901a9481fb2e93ad8ed10dfd9
Publikováno v:
Limnology and Oceanography Letters.
Autor:
Davi D. Bock, Laramie Leavitt, Eric Perlman, István Taisz, Feng Li, Larry Lindsey, Michał Januszewski, Peter H. Li, Jeremy Maitin-Shepard, Gregory S.X.E. Jefferis, Alexander Shakeel Bates, Michael D. Tyka, Matthew Nichols, Viren Jain, Zhihao Zheng, Tim Blakely
Publikováno v:
SSRN Electronic Journal.
Reconstruction of neural circuitry at single-synapse resolution is a key target for improving understanding of the nervous system in health and disease. Serial section transmission electron microscopy (ssTEM) is among the most prolific imaging method
Autor:
Sarel J. Fleishman, Tamar Unger, Orly Dym, Gideon Lapidoth, Dror Baran, Christoffer Norn, M. Gabriele Pszolla, Michael D. Tyka, Shira Albeck
Publikováno v:
'Proceedings of the National Academy of Sciences of the USA ', vol: 114, pages: 10900-10905 (2017)
Natural proteins must both fold into a stable conformation and exert their molecular function. To date, computational design has successfully produced stable and atomically accurate proteins by using so-called “ideal” folds rich in regular second
Autor:
István Taisz, Michał Januszewski, Michael D. Tyka, Gregory S.X.E. Jefferis, Jeremy Maitin-Shepard, Viren Jain, Alexander Shakeel Bates, Eric Perlman, Zhihao Zheng, Laramie Leavitt, Feng Li, Matthew Nichols, Larry Lindsey, Tim Blakely, Peter H. Li, Davi D. Bock
Publikováno v:
bioRxiv
Reconstruction of neural circuitry at single-synapse resolution is a key target for improving understanding of the nervous system in health and disease. Serial section transmission electron microscopy (ssTEM) is among the most prolific imaging method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe587e86259a2a4b0e180f5a4ee847e5
https://doi.org/10.1101/605634
https://doi.org/10.1101/605634
Autor:
Art Pope, Tim Blakely, Peter H. Li, Michał Januszewski, Viren Jain, Jeremy Maitin-Shepard, Larry Lindsey, Winfried Denk, Michael D. Tyka, Jörgen Kornfeld
Publikováno v:
Nature Methods
Reconstruction of neural circuits from volume electron microscopy data requires the tracing of cells in their entirety, including all their neurites. Automated approaches have been developed for tracing, but their error rates are too high to generate
Autor:
Larry Lindsey, Peter H. Li, Tim Blakely, Michał Januszewski, Jeremy Maitin-Shepard, Viren Jain, Michael D. Tyka
Publikováno v:
Microscopy and Microanalysis. 25:1364-1365
Autor:
Dror Baran, Sarel J. Fleishman, Michael D. Tyka, Christoffer Norn, Assaf Alon, Gabriele M. Pszolla, Gideon Lapidoth
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 83:1385-1406
Computational design of protein function has made substantial progress, generating new enzymes, binders, inhibitors, and nanomaterials not previously seen in nature. However, the ability to design new protein backbones for function--essential to exer
Publikováno v:
Protein Science. 23:47-55
A key issue in macromolecular structure modeling is the granularity of the molecular representation. A fine-grained representation can approximate the actual structure more accurately, but may require many more degrees of freedom than a coarse-graine
Publikováno v:
Journal of Computational Chemistry. 33:2483-2491
All-atom sampling is a critical and compute-intensive end stage to protein structural modeling. Because of the vast size and extreme ruggedness of conformational space, even close to the native structure, the high-resolution sampling problem is almos