Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael D. Tomasini"'
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196133 (2018)
We report a computational model for the assembly of HIV-1 Gag into immature viral particles at the plasma membrane. To reproduce experimental structural and kinetic properties of assembly, a process occurring on the order of minutes, a coarse-grained
Externí odkaz:
https://doaj.org/article/e5cb20d2acf648958ca2e31702b2dee1
Autor:
Mahsa Shirani, Solomon Levin, Michael D. Tomasini, James Knox, Bassem Shebl, David Requena, Jackson Clark, Søren Heissel, Hanan Alwaseem, Rodrigo Surjan, Ron Lahasky, Henrik Molina, Barbara Lyons, Rachael D. Migler, Philip Coffino, Sanford M. Simon
Publikováno v:
Cancer Research. 83:6729-6729
In fibrolamellar hepatocellular carcinoma (FLC), hyperammonemic encephalopathy is a common occurrence and occasionally causes death. Using mass spectrometry, we quantitatively analyzed the proteomes of FLC patient’s tumor and adjacent normal, to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917e9d4d7428fb8a5021fd6b16226174
https://doi.org/10.1158/1538-7445.am2023-6729
https://doi.org/10.1158/1538-7445.am2023-6729
Autor:
Sanford M. Simon, Lixin Fan, Baohua Cao, Ping Zhang, Juliana A. Martinez Fiesco, Susan S. Taylor, Tsan-Wen Lu, Michael D. Tomasini
Fibrolamellar hepatocellular carcinoma (FLHCC) is driven by J-PKAcα, a kinase fusion chimera of the J-domain of DnaJB1 with PKAcα, the catalytic subunit of Protein Kinase A (PKA). Here we report the crystal structures of the chimeric fusion RIα2:J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7ad2b45a4d94704e7ac58b01742dd1
Autor:
Michael D. Tomasini, Ruisi Wang, Melissa Jarmel, David Requena, Sanford M. Simon, Denise Ng, Gadi Lalazar
Publikováno v:
Cancer Research. 80:A51-A51
Introduction: Fibrolamellar hepatocellular carcinoma (FLC) is a liver cancer affecting adolescents and young adults without underlying liver disease. Patients with FLC are often diagnosed with advanced-stage disease and have a poor 5-year survival. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ba0e647a7140de08bb417635bea3d1b
https://doi.org/10.1158/1538-7445.pedca19-a51
https://doi.org/10.1158/1538-7445.pedca19-a51
Autor:
Lixin Fan, Tsan-Wen Lu, Baohua Cao, Juliana A. Martinez Fiesco, Sanford M. Simon, Susan S. Taylor, Michael D. Tomasini, Ping Zhang
Publikováno v:
Structure
Fibrolamellar hepatocellular carcinoma (FLHCC) is driven by J-PKAcα, a kinase fusion chimera of the J-domain of DnaJB1 with PKAcα, the catalytic subunit of Protein Kinase A (PKA). Here we report the crystal structures of the chimeric fusion RIα(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24734e860d682cd2bf86ed23dadca86c
https://pubmed.ncbi.nlm.nih.gov/30905674
https://pubmed.ncbi.nlm.nih.gov/30905674
Autor:
Prabhas V. Moghe, Michael D. Tomasini, William J. Welsh, Li Gu, Vladyslav Kholodovych, N. Sanjeeva Murthy, Kathryn E. Uhrich, Adriana A. T. Martin, Sven D. Sommerfeld
Publikováno v:
Journal of Functional Biomaterials
Volume 6
Issue 2
Pages 171-191
Journal of functional biomaterials, vol 6, iss 2
Journal of Functional Biomaterials, Vol 6, Iss 2, Pp 171-191 (2015)
Volume 6
Issue 2
Pages 171-191
Journal of functional biomaterials, vol 6, iss 2
Journal of Functional Biomaterials, Vol 6, Iss 2, Pp 171-191 (2015)
The design and synthesis of enhanced membrane-intercalating biomaterials for drug delivery or vascular membrane targeting is currently challenged by the lack of screening and prediction tools. The present work demonstrates the generation of a Quantit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a904349fc6c4a639e777f54345512697
https://doi.org/10.3390/jfb6020171
https://doi.org/10.3390/jfb6020171
Autor:
Thijs Beuming, Yingjie Wang, Adak Karamafrooz, Sanford M. Simon, Jiali Gao, Geoffrey Li, Gianluigi Veglia, Michael D. Tomasini, Susan S. Taylor
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
In fibrolamellar hepatocellular carcinoma a single genetic deletion results in the fusion of the first exon of the heat shock protein 40, DNAJB1, which encodes the J domain, with exons 2–10 of the catalytic subunit of protein kinase A, PRKACA. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25d1e9763c46a5c81b22a48ed1381a9
https://pubmed.ncbi.nlm.nih.gov/29335433
https://pubmed.ncbi.nlm.nih.gov/29335433
Publikováno v:
The Journal of General Physiology
The phenylalanine-glycine–repeat nucleoporins are essential for transport through the nuclear pore complex. Pulupa et al. observe reptation of these nucleoporins on a physiological timescale in coarse-grained computational simulations.
The phe
The phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea7e16a4fad37dfeec9c3ed9444308a
https://pubmed.ncbi.nlm.nih.gov/28887410
https://pubmed.ncbi.nlm.nih.gov/28887410
Autor:
William J. Welsh, Kathryn E. Uhrich, Michael D. Tomasini, Dalia Abdelhamid, Vladyslav Kholodovych, Daniel R. Lewis, Latrisha K. Petersen, Prabhas V. Moghe
Publikováno v:
Biomaterials, vol 34, iss 32
Atherogenesis, the uncontrolled deposition of modified lipoproteins in inflamed arteries, serves as a focal trigger of cardiovascular disease (CVD). Polymeric biomaterials have been envisioned to counteract atherogenesis based on their ability to rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb69736b5c611458a8f3b1b7f038dea
https://doi.org/10.1016/j.biomaterials.2013.07.011
https://doi.org/10.1016/j.biomaterials.2013.07.011
Publikováno v:
Chemical Engineering Science. 71:400-408
Magnetic Fluid Hyperthermia (MFH) is an encouraging cancer treatment involving superparamagnetic nanoparticles coated with bio-active molecules. When placed in an oscillating magnetic field, the particles release heat into the tumor environment. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886195a6105cb52f14883970bcd09681
https://doi.org/10.1016/j.ces.2011.10.061
https://doi.org/10.1016/j.ces.2011.10.061