Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Michael D. Sunshine"'
Autor:
Michael D. Sunshine, Victoria E. Bindi, Branden L. Nguyen, Vivian Doerr, Franccesco P. Boeno, Vijayendran Chandran, Ashley J. Smuder, David D. Fuller
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Acute hyperbaric O2 (HBO) therapy after spinal cord injury (SCI) can reduce inflammation and increase neuronal survival. To our knowledge, it is unknown if these benefits of HBO require hyperbaric vs. normobaric hyperoxia. We used a C4 later
Externí odkaz:
https://doaj.org/article/a1c2a9cb7b7b4776838417b286494d40
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Impaired diaphragm activation is common in many neuromuscular diseases. We hypothesized that expressing photoreceptors in diaphragm myofibers would enable light stimulation to evoke functional diaphragm activity, similar to endogenous bursts
Externí odkaz:
https://doaj.org/article/1e8ec7e8d0284e4a921773f98e8ee292
Autor:
Michael D. Sunshine, Antonino M. Cassarà, Esra Neufeld, Nir Grossman, Thomas H. Mareci, Kevin J. Otto, Edward S. Boyden, David D. Fuller
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Sunshine et al use a combination of rat models and in silico modeling to show that temporal interference stimulation can prevent fatal apneas after opioid overdose, and can activate the diaphragm after spinal cord injury. This potentially paves the w
Externí odkaz:
https://doaj.org/article/2b94bcb188db43d4a437d393abdb0f27
Autor:
Janak Gaire, Justin A. Varholick, Sabhya Rana, Michael D. Sunshine, Sylvain Doré, W. Brad Barbazuk, David D. Fuller, Malcolm Maden, Chelsey S. Simmons
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-6 (2021)
Abstract The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-r
Externí odkaz:
https://doaj.org/article/4306fc73e62c49328f78cf0387d70821
Autor:
Brendan M. Doyle, Sara M.F. Turner, Michael D. Sunshine, Phillip A. Doerfler, Amy E. Poirier, Lauren A. Vaught, Marda L. Jorgensen, Darin J. Falk, Barry J. Byrne, David D. Fuller
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 194-203 (2019)
Pompe disease is caused by mutations in the gene encoding the lysosomal glycogen-metabolizing enzyme, acid-alpha glucosidase (GAA). Tongue myofibers and hypoglossal motoneurons appear to be particularly susceptible in Pompe disease. Here we used intr
Externí odkaz:
https://doaj.org/article/605955560d5c4490b43140dff4ed8fea
Autor:
Michael D. Sunshine, David D. Fuller
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Whole body plethysmography (WBP) monitors respiratory rate and depth but conventional analysis fails to capture the diversity of waveforms. Our first purpose was to develop a waveform cluster analysis method for quantifying dynamic changes in respira
Externí odkaz:
https://doaj.org/article/8522f622dbf54abc95357604ad12cca8
Autor:
Vivian Doerr, Ryan N. Montalvo, Branden L. Nguyen, Franccesco P. Boeno, Michael D. Sunshine, Victoria E. Bindi, David D. Fuller, Ashley J. Smuder
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 2073 (2022)
Cardiorespiratory dysfunction resulting from doxorubicin (DOX) chemotherapy treatment is a debilitating condition affecting cancer patient outcomes and quality of life. DOX treatment promotes cardiac and respiratory muscle pathology due to enhanced r
Externí odkaz:
https://doaj.org/article/302a7f5add414acba0a9f0e9d6742e6c
Publikováno v:
J Neurophysiol
Repeated short episodes of hypoxia produce a sustained increase in phrenic nerve output lasting well beyond acute intermittent hypoxia (AIH) exposure (i.e., phrenic long-term facilitation; pLTF). Pretreatment with ampakines, drugs which allostericall
Autor:
Gordon S. Mitchell, Elisa J. Gonzalez-Rothi, Joseph F. Welch, Ashley Ross, Juliet Santiago, Ashley Holland, Michael D. Sunshine, Raphael R. Perim
Publikováno v:
J Neurophysiol
Plasticity is a hallmark of the respiratory neural control system. Phrenic long-term facilitation (pLTF) is one form of respiratory plasticity characterized by persistent increases in phrenic nerve activity following acute intermittent hypoxia (AIH).
Autor:
David D. Fuller, Victoria E. Bindi, Anthony T. Yachnis, Michael D. Sunshine, Jorge A. Trejo-Lopez, Barbara K. Smith, Barry J. Byrne, Sabhya Rana
Publikováno v:
J Neurophysiol
Pompe disease (PD) is a neuromuscular disorder caused by a mutation in the acid alpha-glucosidase (GAA) gene. Patients with late-onset PD retain some GAA activity and present symptoms later in life, with fatality mainly associated with respiratory fa