Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

Autor: R. Glenn King, Aaron Silva-Sanchez, Jessica N. Peel, Davide Botta, Alexandria M. Dickson, Amelia K. Pinto, Selene Meza-Perez, S. Rameeza Allie, Michael D. Schultz, Mingyong Liu, John E. Bradley, Shihong Qiu, Guang Yang, Fen Zhou, Esther Zumaquero, Thomas S. Simpler, Betty Mousseau, John T. Killian, Brittany Dean, Qiao Shang, Jennifer L. Tipper, Christopher A. Risley, Kevin S. Harrod, Tsungwei Feng, Young Lee, Bethlehem Shiberu, Vyjayanthi Krishnan, Isabelle Peguillet, Jianfeng Zhang, Todd J. Green, Troy D. Randall, John J. Suschak, Bertrand Georges, James D. Brien, Frances E. Lund, M. Scot Roberts

Publikováno v: Vaccines, Vol 9, Iss 8, p 881 (2021)

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Intranasal vaccination is an attractive str

Externí odkaz: https://doaj.org/article/2c3ec67e167b48a7a637b11e247315c6

Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission

Autor: Madeleine F. Jennewein, Michael D. Schultz, Samuel Beaver, Peter Battisti, Julie Bakken, Derek Hanson, Jobaida Akther, Raodoh Mohamath, Jasneet Singh, Noah Cross, Sierra Reed, Davies Kalange, Jeremy B. Foote, R. Glenn King, Aaron Silva-Sanchez, Davide Botta, Alana Gerhardt, Corey Casper, Troy D. Randall, Frances E. Lund, Emily A. Voigt

While mRNA vaccines have been effective in combating SARS-CoV-2, waning of vaccine-induced antibody responses and lack of vaccine-induced respiratory tract immunity contribute to ongoing infection and transmission. In this work, we compare and contra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf96c4195ec323dc2a0735968d33964
https://doi.org/10.1101/2022.11.10.515993

Lung dendritic cells migrate to the spleen to prime long-lived TCF1

Autor: Meagan M, Jenkins, Holly, Bachus, Davide, Botta, Michael D, Schultz, Alexander F, Rosenberg, Beatriz, León, André, Ballesteros-Tato

Publikováno v: Sci Immunol

CD8(+) T cell responses to pulmonary challenges are primed by lung migratory dendritic cells (mDCs), which capture antigens in the lungs and migrate to the lung-draining mediastinal lymph node (med-LN) to activate T cells. Notably, the lungs and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5381d8228790f4c6c0e39fd4449c1878
https://pubmed.ncbi.nlm.nih.gov/34516781

The establishment of resident memory B cells in the lung requires local antigen encounter

Autor: Beth A. Graf, Frances E. Lund, Michael D. Schultz, S. Rameeza Allie, Uma Mudunuru, John E. Bradley, Troy D. Randall

Publikováno v: Nature immunology

Memory B cells are found in lymphoid and non-lymphoid tissues, suggesting that some may be tissue-resident cells. Here we show that pulmonary influenza infection elicited lung-resident memory B cells (BRM cells) that were phenotypically and functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3759d0ffd346806e924aa215ae308bd3
https://doi.org/10.1038/s41590-018-0260-6

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

Autor: Jeremy B. Foote, Hélène Muller-Steffner, Davide Botta, Sylvain A. Jacques, Leonardo Sorci, Frances E. Lund, Tulin Dadali, Michael D. Schultz, Esther Kellenberger

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2020, 16 (5), pp.e1008539. ⟨10.1371/journal.ppat.1008539⟩
PLoS Pathogens, Vol 16, Iss 5, p e1008539 (2020)

NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for de novo NAD biosynthesis, we evaluated whether these parasites, which infect >200 million pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20ecca6a432763778842c9c459bf2b9
https://hal.archives-ouvertes.fr/hal-03021592