Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael D. Rotelli"'
Autor:
Michael D. Rotelli, Anna M. Bolling, Andrew W. Killion, Abraham J. Weinberg, Michael J. Dixon, Brian R. Calvi
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 10, Pp 3087-3100 (2019)
Cell division and tissue growth must be coordinated with development. Defects in these processes are the basis for a number of diseases, including developmental malformations and cancer. We have conducted an unbiased RNAi screen for genes that are re
Externí odkaz:
https://doaj.org/article/6955dd8477eb4716aa63a865d1ab46bb
Autor:
Anna M. Bolling, Abraham J. Weinberg, Michael D. Rotelli, Michael J. Dixon, Andrew W. Killion, Brian R. Calvi
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 10, Pp 3087-3100 (2019)
Cell division and tissue growth must be coordinated with development. Defects in these processes are the basis for a number of diseases, including developmental malformations and cancer. We have conducted an unbiased RNAi screen for genes that are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cdb9470626dfbe809c47e5ece9ff9b
https://doi.org/10.1534/g3.119.400581
https://doi.org/10.1534/g3.119.400581
Autor:
Gabriel E. Zentner, Brian R. Calvi, Mary A. Lilly, Michael J. Dixon, Anna M. Bolling, Andrew W. Killion, Claire E. Walczak, Michael D. Rotelli, Robert A. Policastro, Abraham J. Weinberg
SummaryCells switch to polyploid endoreplication cycles during development, wound healing, and cancer. We used integrated approaches inDrosophilato determine how mitotic cycles are remodeled into endoreplication cycles, and how similar this remodelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1bfd5b0aaff55bf1df3ea6b577b016
Autor:
Kim Hien T. Dao, Cristina E. Tognon, Michael D. Rotelli, Jeffrey W. Tyner, Juha Rantala, Brieanna Brown, Grover C. Bagby, Jane E. Yates, Brian J. Druker
Publikováno v:
Molecular Biology of the Cell
The Fanconi anemia pathway supports hematopoietic stem cell survival in response to inflammatory and metabolic stress. We show that polyubiquitination and proteasome degradation of FANCL is inhibited by Akt1 activation, revealing a potentially import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a79b7effa483c0657af0a8e7982a7da
https://doi.org/10.1091/mbc.e13-03-0144
https://doi.org/10.1091/mbc.e13-03-0144
Autor:
Amy E. Hanlon Newell, Jane E. Yates, Susan B. Olson, Stefanie Kaech, Kim Hien T. Dao, Grover C. Bagby, Brian J. Druker, Curtis L. Petersen, Whitney D. Nelson, Michael D. Rotelli
Publikováno v:
Blood. 120:323-334
Bone marrow failure is a nearly universal complication of Fanconi anemia. The proteins encoded by FANC genes are involved in DNA damage responses through the formation of a multisubunit nuclear complex that facilitates the E3 ubiquitin ligase activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f225f3ddda11bf8f1ce70740f3d3876
https://doi.org/10.1182/blood-2011-11-388355
https://doi.org/10.1182/blood-2011-11-388355
Publikováno v:
Cell death and differentiation. 22(12)
The p53 protein is a major mediator of the cellular response to genotoxic stress and is a crucial suppressor of tumor formation. In a variety of organisms, p53 and its paralogs, p63 and p73, each encode multiple protein isoforms through alternative s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c19a9e3edeb17b0f9f1a6143b52a9f1
https://pubmed.ncbi.nlm.nih.gov/25882045
https://pubmed.ncbi.nlm.nih.gov/25882045
Autor:
Cristina E. Tognon, Jane E. Yates, Juha Rantala, Kim Hien T. Dao, Michael D. Rotelli, Grover C. Bagby, Brieanna Brown, Brian J. Druker, Jeffrey W. Tyner
Publikováno v:
Experimental Hematology. 41:S42
Fanconi anemia hematopoietic stem cells display poor self-renewal capacity when subjected to a variety of cellular stress. This phenotype raises the question of whether the Fanconi anemia proteins are stabilized or recruited as part of a stress respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ade665bdd93d486a1260f9f19d9f3fd2
https://doi.org/10.1016/j.exphem.2013.05.165
https://doi.org/10.1016/j.exphem.2013.05.165
Autor:
Kim-Hien T. Dao, Brian J. Druker, Jane E. Yates, Michael D. Rotelli, Brieanna Brown, Keaney Rathbun, Juha Rantala, Grover C. Bagby, Jeffrey W. Tyner
Publikováno v:
Blood. 120:1263-1263
Abstract 1263 The molecular basis for how a Fanconi anemia (FA) genetic background contributes to hematopoietic stem cell defects and hypoplastic organ development remains poorly understood. Protein modification by ubiquitination is a mechanism that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad836eb3d7c08da360d02440aec00056
https://doi.org/10.1182/blood.v120.21.1263.1263
https://doi.org/10.1182/blood.v120.21.1263.1263
Autor:
Kim-Hien T. Dao, Michael D. Rotelli, Curtis L. Petersen, Brie R. Brown, Whitney D. Nelson, Jane E. Yates, Amy Hanlon Newell, Susan B. Olson, Brian J. Druker, Grover C. Bagby
Publikováno v:
Blood. 118:1335-1335
Abstract 1335 Fanconi anemia (FA) is associated with a hereditary predisposition to bone marrow failure. The proteins encoded by the FANC genes are primarily involved in DNA repair responses through the formation of a large, multisubunit complex that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c518e761045bbcf91d47c8a9aacef5
https://doi.org/10.1182/blood.v118.21.1335.1335
https://doi.org/10.1182/blood.v118.21.1335.1335
Autor:
Michael D Rotelli, Robert A Policastro, Anna M Bolling, Andrew W Killion, Abraham J Weinberg, Michael J Dixon, Gabriel E Zentner, Claire E Walczak, Mary A Lilly, Brian R Calvi
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008253 (2019)
Endoreplication is a cell cycle variant that entails cell growth and periodic genome duplication without cell division, and results in large, polyploid cells. Cells switch from mitotic cycles to endoreplication cycles during development, and also in
Externí odkaz:
https://doaj.org/article/9b03fb4650ca4d9a83cd8d323520dde5