Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Michael D. Randall"'
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present
Externí odkaz:
https://doaj.org/article/f3466c62953d4111883105461e2dba3d
Publikováno v:
PPAR Research, Vol 2009 (2009)
The aim of the present study was to examine whether endocannabinoids cause PPAR𝛾-mediated vascular actions. Functional vascular studies were carried out in rat aortae. Anandamide and N-arachidonoyl-dopamine (NADA), but not palmitoylethanolamide, c
Externí odkaz:
https://doaj.org/article/b23e0f5a09c547b39d095860b3bafefb
Autor:
Adithan Ganesh, Michael D. Randall
Publikováno v:
British journal of clinical pharmacology. 88(6)
The COVID-19 pandemic is a global public health emergency and patients with diabetes mellitus (DM) are disproportionately affected, exhibiting more severe outcomes. Recent studies have shown that metformin is associated with improved outcomes in pati
Publikováno v:
The Journal of Physiology. 595:6623-6634
Previous studies have demonstrated that perivascular adipose tissue (PVAT) causes vasoconstriction. In this present study, we determined the role of cyclooxygenase-derived prostanoids in this contractile response and determined whether there were any
Publikováno v:
British Journal of Pharmacology. 174:2773-2783
Background and Purpose- As there is sexual dimorphism in the regulation of vascular tone, the aim of this present study was to determine whether there are sex differences in perivascular adipose tissue (PVAT) - mediated regulation of the porcine coro
Autor:
Helen F. Boardman, Michael D. Randall, Cristina I. De Matteis, Andrew Morris, G. Sebastiaan Winkler, Eleanor J. Harvey
Publikováno v:
American journal of pharmaceutical education. 83(1)
Objective: To design an integrated dyspepsia module for first year pharmacy undergraduates, which combines clinical and professional practice with fundamental sciences, in five different science subject areas, as a prototype for future disease- or sy
Publikováno v:
Pharmacological Research. 91:29-35
Oxygenation with 95%O2 is routinely used in organ bath studies. However, hyperoxia may affect tissue responses, particularly in studies which involve reactive oxygen species (ROS). Here, the effects of the antioxidant, Tiron, were investigated under
Publikováno v:
British Journal of Pharmacology. 171:2751-2766
BACKGROUND AND PURPOSE: Cardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in endothelial function. Here, sex differences in endothelial function of porcine coronary art
Publikováno v:
European Journal of Pharmacology. 720:376-382
Circulating levels of anandamide are increased in diabetes, and cannabidiol ameliorates a number of pathologies associated with diabetes. The aim of the present study was to examine how exposure to anandamide or cannabidiol might affect endothelial d
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