Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michael D. Parkes"'
Autor:
Kieran Halloran, Martina Mackova, Michael D Parkes, Alim Hirji, Justin Weinkauf, Irina L Timofte, Greg I Snell, Glen P Westall, Robert Lischke, Andrea Zajacova, Jan Havlin, Ramsey Hachem, Daniel Kreisel, Deborah Levine, Bartosz Kubisa, Maria Piotrowska, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F Halloran
Publikováno v:
The Journal of Heart and Lung Transplantation. 41:1689-1699
Many lung transplants fail due to chronic lung allograft dysfunction (CLAD). We recently showed that transbronchial biopsies (TBBs) from CLAD patients manifest severe parenchymal injury and dedifferentiation, distinct from time-dependent changes. The
Autor:
Greg Snell, Jan Havlin, Michael D. Parkes, Robert Lischke, Peter Jaksch, Daniel Kreisel, I. Timofte, Bartosz Kubisa, A. Hirji, Kieran Halloran, Walter Klepetko, Shane Pon, Philip F. Halloran, Justin Weinkauf, Stephen C. Juvet, Shaf Keshavjee, Maria Piotrowska, Deborah Levine, Ramsey R. Hachem, Andrea Zajacová, Glen P. Westall
Publikováno v:
American Journal of Transplantation. 22:1054-1072
Transplanted lungs suffer worse outcomes than other organ transplants with many developing chronic lung allograft dysfunction (CLAD), diagnosed by physiologic changes. Histology of transbronchial biopsies (TBB) yields little insight, and the molecula
Autor:
Robert Lischke, A. Hirji, Ramsey R. Hachem, Gregory I Snell, Stephen C. Juvet, Philip F. Halloran, Walter Klepetko, Glen P. Westall, Michael D. Parkes, Bartosz Kubisa, I. Timofte, Justin Weinkauf, Shaf Keshavjee, Kieran Halloran, Peter Jaksch, Deborah Levine, Jan Havlin, Maria Piotrowska, Daniel Kreisel
Publikováno v:
The Journal of Heart and Lung Transplantation. 39:1327-1337
BACKGROUND We previously developed molecular assessment systems for lung transplant transbronchial biopsies (TBBs) with high surfactant and bronchial mucosal biopsies, identifying T-cell‒mediated rejection (TCMR) on the basis of the expression of r
Autor:
Ramsey R. Hachem, Deborah Levine, Gregory I Snell, Michael D. Parkes, Philip F. Halloran, Glen P. Westall, A. Hirji, Justin Weinkauf, Peter Jaksch, Walter Klepetko, Kieran Halloran, Stephen C. Juvet, I. Timofte, Shaf Keshavjee, Daniel Kreisel
Publikováno v:
American Journal of Transplantation. 20:954-966
Diagnosing lung transplant rejection currently depends on histologic assessment of transbronchial biopsies (TBB) with limited reproducibility and considerable risk of complications. Mucosal biopsies are safer but not histologically interpretable. Mic
Autor:
Gregory I Snell, I. Timofte, Walter Klepetko, Stephen C. Juvet, Glen P. Westall, Michael D. Parkes, Antoine Roux, Peter Jaksch, Philip F. Halloran, Kieran Halloran, Ramsey R. Hachem, Elbert P. Trulock, Daniel Kreisel, Shaf Keshavjee, Jessica Chang
Publikováno v:
The Journal of Heart and Lung Transplantation. 38:504-513
BACKGROUND Improved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is diff
Autor:
A. Aliabadi-Zuckermann, Michael D. Parkes, Eugene C. DePasquale, Andreas Zuckermann, Katelynn S. Madill-Thomsen, Peter S. Macdonald, J. Stehlik, Daniel Kim, Jon A. Kobashigawa, Keyur B. Shah, J. Goekler, Marisa G. Crespo-Leiro, Martin Cadeiras, Luciano Potena, Philip F. Halloran, Mario C. Deng, M. Mackova
Purpose The INTERHEART study previously used microarray assessment of 889 heart transplant biopsies to develop the Molecular Microscope Diagnostic System (MMDx) based on expression of rejection-associated transcripts (RATs). The present study reclass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0890d2a31de20c3bf99ec4ace69d727
https://hdl.handle.net/10453/155919
https://hdl.handle.net/10453/155919
Autor:
Michael D. Parkes, Prodipto Pal, Liran Levy, Nina Chang, Peter Riddell, T. Martinu, Kieran Halloran, Stephen C. Juvet, P. F. Halloran, Shaf Keshavjee, Lianne G. Singer, S. Moshkelgosha
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 2, Pp n/a-n/a (2021)
Clinical & Translational Immunology
Clinical & Translational Immunology
Objective COPA syndrome is a genetic disorder of retrograde cis‐Golgi vesicle transport that leads to upregulation of pro‐inflammatory cytokines (mainly IL‐1β and IL‐6) and the development of interstitial lung disease (ILD). The impact of CO
Autor:
Jeffery M. Venner, Philip F. Halloran, Luis G. Hidalgo, Michael D. Parkes, Konrad S. Famulski, Katelynn S. Madill-Thomsen, Gunilla Einecke
Publikováno v:
American Journal of Transplantation. 18:785-795
The molecular mechanisms operating in human organ transplant rejection are best inferred from the mRNAs expressed in biopsies because the corresponding proteins often have low expression and short half-lives, while small non-coding RNAs lack specific
Publikováno v:
Transplantation
BACKGROUND: Natural killer (NK) cells localize in the microcirculation in antibody-mediated rejection (AMR) and have been postulated to be activated by donor-specific anti-HLA antibodies triggering their CD16a Fc receptors. However, direct evidence f
Autor:
Daniel Kreisel, Robert Lischke, I. Timofte, Kieran Halloran, Michael D. Parkes, Jan Havlin, Peter Jaksch, Walter Klepetko, Gregory I Snell, Bartosz Kubisa, Glen P. Westall, Deborah Levine, Ramsey R. Hachem, A. Hirji, Philip F. Halloran, Justin Weinkauf, Stephen C. Juvet, Maria Piotrowska, Shaf Keshavjee
Publikováno v:
The Journal of Heart and Lung Transplantation. 40:S61
Purpose The molecular pathogenesis of chronic lung allograft dysfunction (CLAD) is poorly understood. We hypothesized that microarray analysis of TBBs and mucosal biopsies from the third bronchial bifurcation (3BMBs) would provide insight into biolog