Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michael D. Parker"'
Autor:
Robert P. Franklin, Hailu Kinde, Michele T. Jay, Laura D. Kramer, Emily-Gene N. Green, Robert E. Chiles, Eileen Ostlund, Stan Husted, Jonathan Smith, Michael D. Parker
Publikováno v:
Emerging Infectious Diseases, Vol 8, Iss 3, Pp 283-288 (2002)
A yearling quarter horse, which was raised in southern California, received routine vaccinations for prevention of infection by Eastern equine encephalomyelitis virus (EEEV). One week later, severe neurologic signs developed, and the horse was humane
Externí odkaz:
https://doaj.org/article/c7ad9e7284e641b98cb6d6cab490113d
Autor:
Aimee Porter, Laurie J. Hartman, Pamela J. Glass, Michael D. Parker, Nancy A. Twenhafel, Luis DaSilva, Taylor B. Chance, Steven B Yee, Steven J. Kern, Rebecca Erwin-Cohen, David A. Norwood
Publikováno v:
Virology Journal
Background Licensed antiviral therapeutics and vaccines to protect against eastern equine encephalitis virus (EEEV) in humans currently do not exist. Animal models that faithfully recapitulate the clinical characteristics of human EEEV encephalitic d
Autor:
Michael D. Parker, Marilyn J. Buckley, Mary Kate Hart, Pamela J. Glass, Vanessa R. Melanson, David Norwood
Publikováno v:
Journal of Virology. 84:12683-12690
Six monoclonal antibodies were isolated that exhibited specificity for a furin cleavage site deletion mutant (V3526) of Venezuelan equine encephalitis virus (VEEV). These antibodies comprise a single competition group and bound the E3 glycoprotein of
Autor:
Mary Kate Hart, Michael D. Parker, Cathleen M. Lind, Patricia Garcia, Russell R. Bakken, Pamela J. Glass, Erin Jenkins, Donald L. Fine, Shannon S. Martin
Publikováno v:
Vaccine. 28:3143-3151
V3526, a genetically modified strain of Venezuelan equine encephalitis virus (VEEV), was formalin inactivated for evaluation as a next generation vaccine candidate for VEEV. In this study, we tested formalin-inactivated V3526 (fV3526) with and withou
Autor:
Christopher P. Locher, Cathleen M. Lind, Russell R. Bakken, Michael D. Parker, Connie S. Schmaljohn, Michelle J. Richards, Lesley C. Dupuy, Madan M. Paidhungat, Robert G. Whalen
Publikováno v:
Vaccine. 27:4152-4160
We employed directed molecular evolution to improve the cross-reactivity and immunogenicity of the Venezuelan equine encephalitis virus (VEEV) envelope glycoproteins. The DNA encoding the E1 and E2 proteins from VEEV subtypes IA/B and IE, Mucambo vir
Autor:
Michael D. Parker, Michael J. Turell
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 78:328-332
In an attempt to improve the current live, attenuated vaccine (TC-83) for Venezuelan equine encephalitis virus (VEEV), specific mutations associated with attenuation of VEEV in rodent models were inserted into a full-length cDNA clone of the Trinidad
Publikováno v:
Advanced Drug Delivery Reviews. 57:1293-1314
The heightened concerns about bioterrorism and the use of biowarfare agents have prompted substantial increased efforts towards the development of vaccines against a wide range of organisms, toxins, and viruses. An increasing variety of platforms and
Autor:
Matthew G. Lackemeyer, Cathleen M. Lind, Douglas S. Reed, Lawrence J. Sullivan, Michael D. Parker, William D. Pratt
Publikováno v:
Vaccine. 23:3139-3147
Two live, attenuated strains of Venezuelan equine encephalitis virus (VEE), IE1150K and V3526, were administered to macaques to determine if they could elicit protection against an aerosol challenge with virulent VEE virus of the IE variety (VEEV-IE)
Publikováno v:
The Journal of Infectious Diseases. 189:1013-1017
Because Venezuelan equine encephalitis viruses (VEEVs) are infectious by aerosol, they are considered to be a biological-weapons threat. Nonhuman-primate models are needed to evaluate the efficacy of candidate vaccines. In the present study, cynomolg
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 68:218-221
Specific mutations associated with attenuation of Venezuelan equine encephalitis (VEE) virus in rodent models were identified during efforts to develop an improved VEE vaccine. Analogous mutations were produced in full-length cDNA clones of the Cba 8