Výsledky vyhledávání - "Michael D. Nieves"

Sensorimotor dysfunction in a mild mouse model of cortical contusion injury without significant neuronal loss is associated with increases in inflammatory proteins with innate but not adaptive immune functions

Autor: Martin L. Doughty, Michael D. Nieves, Orion Furmanski

Publikováno v: Journal of neuroscience researchREFERENCES. 99(6)

Traumatic brain injury is a leading cause of mortality and morbidity in the United States. Acute trauma to the brain triggers chronic secondary injury mechanisms that contribute to long-term neurological impairment. We have developed a single, unilat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a059bf6a9555a23f7afc9d4e6f56122
https://pubmed.ncbi.nlm.nih.gov/33269491

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Host sex and transplanted human induced pluripotent stem cell phenotype interact to influence sensorimotor recovery in a mouse model of cortical contusion injury

Autor: Michael D. Nieves, Martin L. Doughty, Orion Furmanski

Publikováno v: Brain research. 1748

Traumatic brain injury (TBI) is a substantial cause of disability and death worldwide. Primary head trauma triggers chronic secondary injury mechanisms in the brain that are a focus of therapeutic efforts to treat TBI. Currently, there is no successf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d94b68ee10daa70a6a2cb9d9734210d
https://pubmed.ncbi.nlm.nih.gov/32926852

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N eonatal mouse cortical but not isogenic human astrocyte feeder layers enhance the functional maturation of induced pluripotent stem cell‐derived neurons in culture

Autor: Clifton L. Dalgard, Qiong Zhou, Fritz W. Lischka, Nikki M. McCormack, Michael D. Nieves, Anastasia G. Efthymiou, Matthew D. Wilkerson, Martin L. Doughty, Gauthaman Sukumar

Publikováno v: Glia. 66:725-748

Human induced pluripotent stem (iPS) cell-derived neurons and astrocytes are attractive cellular tools for nervous system disease modeling and drug screening. Optimal utilization of these tools requires differentiation protocols that efficiently gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d423f1dd67e69c0a76f97143a288f5e7
https://doi.org/10.1002/glia.23278

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Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Autor: Orion Furmanski, Martin L. Doughty, Michael D. Nieves

Publikováno v: Journal of Visualized Experiments.

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Disease pathology due to TBI progresses from the primary mechanical insult to secondary injury processes, including apoptosis and inflammation. Animal modeling has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5960cea8cbcd40363fb800db2087994e
https://doi.org/10.3791/59561

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