Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy

Autor: Talia A. Shmool, P.J. Woodhams, Markus Leutzsch, Amberley D. Stephens, Mario U. Gaimann, Michael D. Mantle, Gabriele S. Kaminski Schierle, Christopher F. van der Walle, J. Axel Zeitler

Publikováno v: International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)

Characterising the structural dynamics of proteins and the effects of excipients are critical for optimising the design of formulations. In this work we investigated four lyophilised formulations containing bovine serum albumin (BSA) and three formul

Externí odkaz: https://doaj.org/article/e1faea46313e4533852be0c1c8f39ea7

Green, scalable, low cost and reproducible flow synthesis of biocompatible PEG-functionalized iron oxide nanoparticles

Autor: Laura Torrente-Murciano, Luise Fanslau, Christoph O. Franck, Julien Mahin, Hirak K. Patra, Michael D. Mantle, Ljiljana Fruk

Publikováno v: Reaction Chemistry & Engineering. 6:1961-1973

Functionalized iron oxide nanoparticles are of great interest for multiple biomedical applications. However, it remains a considerable challenge to manufacture these nanoparticles reproducibly on a large scale with the appropriate surface coating to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a6608148b4bdaf3503c132c6895512
https://doi.org/10.1039/d1re00239b

Ionic Liquid Microcapsules: Formation and Application of Polystyrene Microcapsules with Ionic Liquid Cores

Autor: Patricia C. Marr, Alexander F. Routh, Michael D. Mantle, Mercedes Fernandez Serrano, Ismael Lobato Guarnido

Publikováno v: Lobato Guarnido, I, Routh, A F, Mantle, M D, Fernandez Serrano, M & Marr, P C 2019, ' Ionic Liquid Microcapsules: Formation and Application of Polystyrene Microcapsules with Ionic Liquid Cores ', ACS Sustainable Chemistry & Engineering . https://doi.org/10.1021/acssuschemeng.8b05478

© 2019 American Chemical Society. The synthesis of 2-3 μm spherical microcapsules with a polymer shell and a liquid core composed of ionic liquid (IL) ([Bmim][NTf2]) is described. These discrete IL microcapsules are prepared quickly and in large qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520ba5ffbd7c3b538ac88c940cf98f96
https://doi.org/10.1021/acssuschemeng.8b05478

Measuring the liquid-solid mass transfer coefficient in packed beds using T2-T2 relaxation exchange NMR

Autor: Michael D. Mantle, Lynn F. Gladden, Scott V. Elgersma, Andrew J. Sederman

Publikováno v: Chemical Engineering Science. 248:117229

Direct measurement of the liquid-solid mass transfer coefficient in packed beds is achieved using T 2 - T 2 relaxation exchange NMR. This method directly probes molecular exchange between intra- and inter-pellet fluid, rather than requiring a net flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::913e881d730e8db120c22d3db4d53887
https://doi.org/10.1016/j.ces.2021.117229

Enabling High Spectral Resolution of Liquid Mixtures in Porous Media by Antidiagonal Projections of Two-Dimensional 1H NMR COSY Spectra

Autor: Camilla Terenzi, Andrew J. Sederman, Lynn F. Gladden, Michael D. Mantle

Publikováno v: Journal of Physical Chemistry Letters 10 (2019) 19
Journal of Physical Chemistry Letters, 10(19), 5781-5785

The noninvasive, in situ chemical identification of liquid mixtures confined in porous materials is experimentally challenging. NMR is chemically resolved and applicable to optically opaque systems but suffers from a significant loss in spectral reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a30cfc6b82774a8e81ae17123c85db