Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael D. Litt"'
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how th
Publikováno v:
Bioscience Reports. 29:131-141
PRMTs (protein arginine N-methyltransferases) specifically modify the arginine residues of key cellular and nuclear proteins as well as histone substrates. Like lysine methylation, transcriptional repression or activation is dependent upon the site a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f02cd59855a0a1aae2ae9126f548cbc
https://doi.org/10.1042/bsr20080176
https://doi.org/10.1042/bsr20080176
Publikováno v:
Genes & Development. 19:1885-1893
PRMT1 is a histone methyltransferase that methylates Arg3 on histone H4. When we used siRNA to knock down PRMT1 in an erythroid cell line, it resulted in nearly complete loss of H4 Arg3 methylation across the chicken β-globin domain, which we use as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a2eba79376e61de30f0d954120f656
https://doi.org/10.1101/gad.1333905
https://doi.org/10.1101/gad.1333905
Publikováno v:
Molecular Cell. 16(3):453-463
The chicken beta-globin 5'HS4 insulator element acts as a barrier to the encroachment of chromosomal silencing. Endogenous 5'HS4 sequences are highly enriched with histone acetylation and H3K4 methylation regardless of neighboring gene expression. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f0555a7e4d026e17f5e6774d94a515
Autor:
Michael D. Litt, C. Ann Blakey
Histones and their modifications are critically important epigenetic mechanisms involved in the regulation of gene expression. There are many different posttranslational modifications on histone tails that are currently identified and more being disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7c7a9c6c86296dc4b2621a3d004484f
https://doi.org/10.1016/b978-0-12-799958-6.00002-0
https://doi.org/10.1016/b978-0-12-799958-6.00002-0
Autor:
Michael D. Litt, C. Ann Blakey
Epigenetics research encompasses a wide range of areas, from basic research on chromatin structure to examination of growth and development of the organism, to investigations of the development and progression of complex diseases. Along the path, epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0d26f83f4ec1a399f0c2866a840f48
https://doi.org/10.1016/b978-0-12-799958-6.00001-9
https://doi.org/10.1016/b978-0-12-799958-6.00001-9
Autor:
Adam C. Bell, Félix Recillas-Targa, Bonnie Burgess-Beusse, Michael D. Litt, Adam G. West, Michael J. Pikaart, Gary Felsenfeld, Miklos Gaszner
Publikováno v:
Proceedings of the National Academy of Sciences. 99:6883-6888
The 1.2-kb DNA sequence element (5′HS4) at the 5′ end of the chicken β-globin locus has the two defining properties of an insulator: it prevents an “external” enhancer from acting on a promoter when placed between them (“enhancer blocking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491f52f6c45c60f2c3322b3dc8d2fa3a
https://doi.org/10.1073/pnas.102179399
https://doi.org/10.1073/pnas.102179399
Publikováno v:
T-Cell Leukemia-Characteristics, Treatment and Prevention
Many molecular alterations are involved in the morphogenesis of T-cell acute leukemia (TALL), classified as lymphoblastic leukemia/lymphoma by the World Health Organization. TALL is a malignant disease of the thymocytes which accounts for approximate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eb27bde79bee602e621aa2010cf0f6
https://doi.org/10.5772/55144
https://doi.org/10.5772/55144
Autor:
Timur M. Yusufzai, R. Ghirlando, Frédérique Magdinier, Miklos Gaszner, Vesco Mutskov, Hideaki Tagami, Michael D. Litt, Catherine M. Farrell, Bonnie Burgess-Beusse, C. Jin, Gary Felsenfeld, Adam G. West, Yoshihiro Nakatani, S. Huang
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology
Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory; 1999, 2004, 69, pp.245-250. ⟨10.1101/sqb.2004.69.245⟩
Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory; 1999, 2004, 69, pp.245-250. ⟨10.1101/sqb.2004.69.245⟩
International audience; Insulator elements were first described in Drosophila, but subsequent studies have shown that they are present in vertebrates as well (for review, see West et al. 2002). Over the past several years we have focused our attentio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee10a97e20fafa849fe871ce3322ba8
https://pubmed.ncbi.nlm.nih.gov/16117655
https://pubmed.ncbi.nlm.nih.gov/16117655
Autor:
Félix Recillas-Targa, Michael D. Litt, Rodolfo Ghirlando, Gary Felsenfeld, Marie-Noëlle Prioleau
Publikováno v:
Journal of molecular biology. 336(3)
We have studied the physical properties of a segment of condensed chromatin that lies upstream of the chicken beta-globin locus. This segment can be excised from an avian erythroleukemia cell line by restriction enzyme digestion and released from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457630c90c0a5f82e76d33cdb6ed7ad0
https://pubmed.ncbi.nlm.nih.gov/15095975
https://pubmed.ncbi.nlm.nih.gov/15095975