Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Michael D. Leavell"'
1
High-throughput screening for high-efficiency small-molecule biosynthesis
Autor: Dana C. Nadler, Shaina Jackson, Timothy Leaf, Thomas J. Schmidt, Matthew Rienzo, Maud Ohler, Lawrence K. Chao, Michael D. Leavell, Adam H. Navidi
Publikováno v: Metabolic Engineering. 63:102-125
Systems metabolic engineering faces the formidable task of rewiring microbial metabolism to cost-effectively generate high-value molecules from a variety of inexpensive feedstocks for many different applications. Because these cellular systems are st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4ac92c36dad4f43bcea7a0a3e82768
https://doi.org/10.1016/j.ymben.2020.09.004
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2
High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring
Autor: Adam H. Navidi, Eric K. Sackmann, Justin K. Valley, Kellen C. Mobilia, Lawrence K. Chao, Troy A. Lionberger, Ke-Chih Lin, Tony Wu, Matthew Rienzo, Jarett King, Hanxiao Jiang, Robert M. Onorato, Michael D. Leavell, Kurz Volker L S
Publikováno v: Lab on a chip. 21(15)
The industrial synthetic biology sector has made huge investments to achieve relevant miniaturized screening systems for scalable fermentation. Here we present the first example of a high-throughput (>103 genotypes per week) perfusion-based screening
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc047fb5e84578c4aa75c75d66aaca3
https://pubmed.ncbi.nlm.nih.gov/34160512
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3
High-throughput screening for improved microbial cell factories, perspective and promise
Autor: Amoolya H. Singh, Michael D. Leavell, Benjamin B Kaufmann-Malaga
Publikováno v: Current opinion in biotechnology. 62
High-throughput screening is a critical part of any industrial strain engineering effort, helping ensure the lowest cost product is produced in the shortest amount of time. Small-scale testing that correlates to manufacturing scale allows rapid strai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971149ec48477fa5d7a48e41a746112a
https://pubmed.ncbi.nlm.nih.gov/31513989
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4
Developing fermentative terpenoid production for commercial usage
Autor: Michael D. Leavell, Chris J. Paddon, Derek McPhee
Publikováno v: Current Opinion in Biotechnology. 37:114-119
Terpenoids comprise a large (>55000) family of compounds, very few of which have been used commercially due to low and economically unpractical production in their native hosts (generally plants and microorganisms). Two examples of natural terpenoid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4782b4665790801b5c85de70b7671e5
https://doi.org/10.1016/j.copbio.2015.10.007
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6
Investigation of ion/molecule reactions as a quantification method for phosphorylated positional isomers: An FT-ICR approach
Autor: Christopher J. Petzold, Julie A. Leary, Hong Gao, Michael D. Leavell
Publikováno v: Journal of the American Society for Mass Spectrometry. 14:916-924
A rapid and accurate method of quantifying positional isomeric mixtures of phosphorylated hexose and N-acetylhexosamine monosacchrides by using gas-phase ion/molecule reactions coupled with FT-ICR mass spectrometry is described. Trimethyl borate, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6286c93cddf07e17cde1c94bd493de84
https://doi.org/10.1016/s1044-0305(03)00401-x
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7
Determination of phosphate position in hexose monosaccharides using an FTICR mass spectrometer: ion/molecule reactions, labeling studies, and dissociation mechanisms
Autor: Julie A. Leary, Michael D. Leavell, Gary Kruppa
Publikováno v: International Journal of Mass Spectrometry. 222:135-153
Determination of phosphate position in carbohydrates using mass spectrometry is difficult due to the low energy loss of the phosphate either as a neutral or as an ion in MS/MS experiments. A possible solution to this problem is proposed in this work,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2c8ffe408aad17159938007e3c455cb
https://doi.org/10.1016/s1387-3806(02)00986-7
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8
Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach
Autor: Joseph D. Mougous, Ryan H. Senaratne, Carolyn R. Bertozzi, Spencer J. Williams, Clifton D. Leigh, Michael D. Leavell, Lee W. Riley, Julie A. Leary
Publikováno v: Proceedings of the National Academy of Sciences. 99:17037-17042
The study of the metabolome presents numerous challenges, first among them being the cataloging of its constituents. A step in this direction will be the development of tools to identify metabolites that share common structural features. The importan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c13d24adc964ebd29ae95c705ffe1a
https://doi.org/10.1073/pnas.252514899
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9
Analysis of Phosphate Position in Hexose Monosaccharides Using Ion−Molecule Reactions and SORI-CID on an FT-ICR Mass Spectrometer
Autor: Gary H. Kruppa, Julie A. Leary, Michael D. Leavell
Publikováno v: Analytical Chemistry. 74:2608-2611
Through the use of ion-molecule reactions and SORI-CID, the phosphate position in hexose phosphate monosaccharides has been determined in the negative ion mode. Trimethyl borate was used as a reagent gas and was found to react readily with the phosph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1010058760f7638b1e0498aaf5a0c43f
https://doi.org/10.1021/ac020054m
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10
Solvent Effects in Tandem Mass Spectrometry: Mechanistic Studies Indicating How a Change in Solvent Conditions and pH Can Dramatically Alter CID Spectra
Autor: Michael D. Leavell, Heather Desaire, Julie A. Leary
Publikováno v: The Journal of Organic Chemistry. 67:3693-3699
Dramatically different CID (collision-induced dissociation) spectra are obtained when the complex [Zn(dien-glucose)](+) is electrosprayed from acidic and basic solutions. To understand this peculiar phenomenon, an in-depth mechanistic study was perfo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4126b51a5b6f05547f521ef22d5a8c18
https://doi.org/10.1021/jo016309y
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