Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael D. LaFleur"'
Autor:
Elizabeth C. Griffith, Nicole A. Vita, Ekaterina Gavrish, Autumn Brown Gandt, Alex K Mugengana, Lei Yang, Richard E. Lee, Kirk E. Hevener, Lalit Kumar Sharma, George Agyapong, Michael D. LaFleur, Jiuyu Liu, Kevin Moran
Publikováno v:
ACS Infectious Diseases. 7:1044-1058
The successful treatment of Helicobacter pylori infections is becoming increasingly difficult due to the rise of resistance against current broad spectrum triple therapy regimens. In the search for narrow-spectrum agents against H. pylori, a high-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153a66473f8a4397db6037501de34da3
https://doi.org/10.1021/acsinfecdis.0c00300
https://doi.org/10.1021/acsinfecdis.0c00300
Publikováno v:
Current Opinion in Microbiology. 70:102203
Helicobacter pylori is an important human pathogen with increasing antimicrobial resistance to standard-of-care antibiotics. Treatment generally includes a combination of classical broad-spectrum antibiotics and a proton-pump inhibitor, which often l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2f54e3726f5c1e4445c171e05925ae
https://doi.org/10.1016/j.mib.2022.102203
https://doi.org/10.1016/j.mib.2022.102203
Autor:
Alex K, Mugengana, Nicole A, Vita, Autumn, Brown Gandt, Kevin, Moran, George, Agyapong, Lalit K, Sharma, Elizabeth C, Griffith, Jiuyu, Liu, Lei, Yang, Ekaterina, Gavrish, Kirk E, Hevener, Michael D, LaFleur, Richard E, Lee
Publikováno v:
ACS Infect Dis
The successful treatment of Helicobacter pylori infections is becoming increasingly difficult due to the rise of resistance against current broad spectrum triple therapy regimens. In the search for narrow-spectrum agents against H. pylori, a high-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::582b75966b450ea5b6e37ee945f4d1fd
https://pubmed.ncbi.nlm.nih.gov/33471519
https://pubmed.ncbi.nlm.nih.gov/33471519
Autor:
Michael D. LaFleur, Autumn Brown Gandt, Angel Han, Aman P. Singh, Elizabeth C. Griffith, Rajendra Tangallapally, Ida Lister, Richard E. Lee, Lisa L. Billings, Ying Zhao
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Antibiotics with novel bactericidal mechanisms of action are urgently needed. The antibiotic acyldepsipeptide 4 (ADEP4) activates the ClpP protease and causes cells to self-digest. The effects of ADEP4 and ClpP activation have not been characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fe75528b4b53edf6e97b5c46d1a324
https://doi.org/10.1128/aac.00424-18
https://doi.org/10.1128/aac.00424-18
Publikováno v:
Journal of Antimicrobial Chemotherapy. 66:820-826
Microbial adhesion and biofilms have important implications for human health and disease. Candida albicans is an opportunistic pathogen which forms drug-resistant biofilms that contribute to the recalcitrance of disease. We have developed a high-thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05fff07d037dfb91fbc80ba1661c031
https://doi.org/10.1093/jac/dkq530
https://doi.org/10.1093/jac/dkq530
Publikováno v:
Antibiotics: Current Innovations and Future Trends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4241aa74701e2ef998be1a24fa29d71f
https://doi.org/10.21775/9781908230546.06
https://doi.org/10.21775/9781908230546.06
Autor:
David Charnuska, Ekaterina Gavrish, E. Jeffrey North, Ida Lister, Chao Chen, Kim Lewis, Michael D. LaFleur, Richard E. Lee, Binu Shrestha, Lei Yang, Bronwyn Williams, Angel Han, Ken Coleman
A high-throughput screen (HTS) was performed to identify molecules specifically active against Helicobacter pylori , the causative agent of peptic ulcer and gastric carcinoma. Currently, treatment of H. pylori infection is suboptimal, with failure ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da10a578eb4720a8ff2de3b3e0a9874f
https://europepmc.org/articles/PMC4068456/
https://europepmc.org/articles/PMC4068456/
Autor:
Joshua N. Adkins, Vincent M. Isabella, Kim Lewis, Laura E. Fleck, Steven N. Leonard, Richard D. Smith, Ken Coleman, Michael D. LaFleur, Brian P. Conlon, Ernesto S. Nakayasu
Publikováno v:
Nature. 503(7476)
Chronic infections are difficult to treat with antibiotics but are caused primarily by drug-sensitive pathogens. Dormant persister cells that are tolerant to killing by antibiotics are responsible for this apparent paradox. Persisters are phenotypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c966c420dfa415f21f1a0c6b8b579a1
https://pubmed.ncbi.nlm.nih.gov/24509763
https://pubmed.ncbi.nlm.nih.gov/24509763
Autor:
Mahmoud A. Ghannoum, Ida Lister, Ken Coleman, Michael D. LaFleur, Kim Lewis, Lingmei Sun, John Keating, André Nantel, Thomas A. Dahl, Jeffrey North, Richard E. Lee, Lisa Long
Publikováno v:
Antimicrobial agents and chemotherapy. 57(8)
Azoles are among the most successful classes of antifungals. They act by inhibiting α-14 lanosterol demethylase in the ergosterol biosynthesis pathway. Oropharyngeal candidiasis (OPC) occurs in about 90% of HIV-infected individuals, and 4 to 5% are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4183195e1531caf796698ccd4993a50
https://pubmed.ncbi.nlm.nih.gov/23689724
https://pubmed.ncbi.nlm.nih.gov/23689724
Fungal biofilms produce a small number of persister cells which can tolerate high concentrations of fungicidal agents. Persisters form upon attachment to a surface, an important step in the pathogenesis of Candida strains. The periodic application of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bf0a87f83a763124c6527f7c656ba1
https://europepmc.org/articles/PMC2798516/
https://europepmc.org/articles/PMC2798516/