Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michael D. Koob"'
Autor:
Paula P. Perissinotti, Elizabeth Martínez-Hernández, Yungui He, Michael D. Koob, Erika S. Piedras-Rentería
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions. We analyzed the electrical behavior of hypotha
Externí odkaz:
https://doaj.org/article/968ce22394b84e7abc7fedf2c3163407
Autor:
Julia Gamache, Kellie Benzow, Colleen Forster, Lisa Kemper, Chris Hlynialuk, Eva Furrow, Karen H. Ashe, Michael D. Koob
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The rTg4510 mosue line has a tauopathy-like phenotype which is attributed to overexpression of human tau in the frontal cortex. Here the authors identify potential confounding genetic factors that could contribute to the phenotype.
Externí odkaz:
https://doaj.org/article/9e0243c9022847c19c905619188b6933
Autor:
Madelyn Castro, Nisha Venkateswaran, Samuel T. Peters, David R. Deyle, Matthew Bower, Michael D. Koob, Bradley F. Boeve, Keith Vossel
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Frontotemporal dementia (FTD) rarely occurs in individuals under the age of 30, and genetic causes of early-onset FTD are largely unknown. The current report follows a 27 year-old patient with no significant past medical history presenting with two y
Externí odkaz:
https://doaj.org/article/89597abc875f4d1eaa2519613dc0141c
Autor:
Paula Patricia Perissinotti, Elizabeth G. Ethington, Erik eAlmazan, Elizabeth eMartínez-Hernández, Jennifer eKalil, Michael D. Koob, Erika S. Piedras-Renteria
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2015)
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (α1H T-type) calcium channels; KLHL1 knockdown experiments (KD) cause down-regulation of both channel types and altered synaptic prope
Externí odkaz:
https://doaj.org/article/1f4d51d0bbea480d847d13029f7caa38
Publikováno v:
The Cerebellum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb85b3ed72bb7edd5ceda0177e376ea
https://doi.org/10.1007/s12311-023-01567-9
https://doi.org/10.1007/s12311-023-01567-9
Autor:
Lisa Duvick, W. Michael Southern, Kellie Benzow, Hillary P. Handler, Jason S. Mitchell, Hannah Kuivinen, Udaya Keerthy Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie Scheeler, Orion Rainwater, Serres Shannah, Erin Larson, Tessa Nichols-Meade, Yun You, Brennon O’Callaghan, Huda Y. Zoghbi, James M. Ervasti, Marija Cvetanovic, Michael D. Koob, Harry T. Orr
Publikováno v:
bioRxiv
Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ATXN1 protein. To elucidate anatomical regions and cell types that underlie mutant ATXN1-induced disease pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097ef39977231952db5f84fa6647e9d2
https://europepmc.org/articles/PMC9934664/
https://europepmc.org/articles/PMC9934664/
Publikováno v:
The Cerebellum.
MicroRNAs, a class of small RNA regulators, function throughout neurodevelopment, from neural stem cell neurogenesis to neuronal maturation, synaptic formation, and plasticity. α1ACT, a transcription factor (TF), plays a critical role in neonatal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6fe423dba6fb297b0470ac60f7c0d8
https://doi.org/10.1007/s12311-022-01431-2
https://doi.org/10.1007/s12311-022-01431-2
Autor:
Elizabeth Martínez-Hernández, Yungui He, Erika S. Piedras-Rentería, Paula P. Perissinotti, Michael D. Koob
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience, Vol 15 (2021)
Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions. We analyzed the electrical behavior of hypotha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8825dc500800e299bc40d0b9edccf71c
https://doi.org/10.3389/fnins.2021.718464
https://doi.org/10.3389/fnins.2021.718464
Autor:
Young Geol Yoon, Michael D. Koob
Publikováno v:
Mitochondrion. 46:15-21
Mitochondrial genomes (mtDNA) depend on the nuclear genome with which they have evolved to provide essential replication functions and have been known to replicate as xenotransplants only in the cells of closely related species. We now report that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387bcce245bdc017a3faddbf6bf98924
https://doi.org/10.1016/j.mito.2019.03.006
https://doi.org/10.1016/j.mito.2019.03.006
Autor:
Chris Hlynialuk, Michael D. Koob, Eva Furrow, Julia E. Gamache, Colleen L. Forster, Lisa J. Kemper, Karen H. Ashe, Kellie A. Benzow
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human tauP301L expression specifically within the forebrain can be temporally controlled, has largely been attributed to high overexpression of mutant human tau in the forebrai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbb5f358e1ca88bfe21796862075590
http://europepmc.org/articles/PMC6554306
http://europepmc.org/articles/PMC6554306