Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Michael D. Kahl"'
Autor:
Erin M. Maloney, Daniel L. Villeneuve, Kathleen M. Jensen, Brett R. Blackwell, Michael D. Kahl, Shane T. Poole, Kelsey Vitense, David J. Feifarek, Grace Patlewicz, Kendra Dean, Charlene Tilton, Eric C. Randolph, Jenna E. Cavallin, Carlie A. LaLone, Donovan Blatz, Christopher M. Schaupp, Gerald T. Ankley
Publikováno v:
Environmental Toxicology and Chemistry. 42:1229-1256
Autor:
Daniel L. Villeneuve, Brett R. Blackwell, Jenna E. Cavallin, Jacob Collins, John X. Hoang, Rachel N. Hofer, Keith A. Houck, Kathleen M. Jensen, Michael D. Kahl, Robin N. Kutsi, Anne S. Opseth, Kelvin J. Santana Rodriguez, Christopher Schaupp, Emma H. Stacy, Gerald T. Ankley
Publikováno v:
Environmental Science & Technology. 57:3794-3803
Autor:
Daniel L. Villeneuve, Brett R. Blackwell, Chad A. Blanksma, Jenna E. Cavallin, Wan‐Yun Cheng, Rory B. Conolly, Kendra Conrow, David J. Feifarek, Larry J. Heinis, Kathleen M. Jensen, Michael D. Kahl, Rebecca Y. Milsk, Shane T. Poole, Eric C. Randolph, Travis W. Saari, Karen H. Watanabe, Gerald T. Ankley
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 42(1)
To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach methodologies (NAMs) that provide relevant scientific information at a quality equivalent to
Autor:
Brett R. Blackwell, Gerald T. Ankley, Adam D. Biales, Jenna E. Cavallin, Alexander R. Cole, Timothy W. Collette, Drew R. Ekman, Rachel N. Hofer, Weichun Huang, Kathleen M. Jensen, Michael D. Kahl, Ashley R. Kittelson, Shannon N. Romano, Mary Jean See, Quincy Teng, Charlene B. Tilton, Daniel L. Villeneuve
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 41(11)
Metformin, along with its biotransformation product guanylurea, is commonly observed in municipal wastewaters and subsequent surface waters. Previous studies in fish have identified metformin as a potential endocrine-active compound, but there are in
Autor:
Brett R. Blackwell, Shane T. Poole, Kathleen M. Jensen, Jenna E. Cavallin, Jonathan D. Mosley, Kellie A. Fay, J. Swintek, Timothy W. Collette, Daniel C. Rearick, Drew R. Ekman, Michael D. Kahl, Eric C. Randolph, Jason P. Berninger, Gerald T. Ankley, Anthony L. Schroeder, Daniel L. Villeneuve, David J Feifarek
Publikováno v:
Environ Toxicol Chem
Assessment of ecological risks of chemicals in the field usually involves complex mixtures of known and unknown compounds. We describe the use of pathway-based chemical and biological approaches to assess the risk of chemical mixtures in the Maumee R
Autor:
Shane T. Poole, Brett R. Blackwell, Jenna E. Cavallin, Michael D. Kahl, David J Feifarek, Kathleen M. Jensen, Eric C. Randolph, Travis W. Saari, Jon A. Doering, Carlie A. LaLone, Daniel L. Villeneuve, Gerald T. Ankley
Publikováno v:
Environ Toxicol Chem
Predictive approaches to assessing the toxicity of contaminant mixtures have been largely limited to chemicals that exert effects through the same biological molecular initiating event. However, by understanding specific pathways through which chemic
Autor:
Eric C. Randolph, Carlie A. LaLone, Michael D. Kahl, Kellie A. Fay, Jon A. Doering, Daniel L. Villeneuve, Gerald T. Ankley, Kathleen M. Jensen
Publikováno v:
Toxicological Sciences. 170:394-403
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the conversion of androgens to estrogens. Inhibition of aromatase
Autor:
Carlie A. LaLone, Michael D. Kahl, Jon A. Doering, Shane T. Poole, Jenna E. Cavallin, Charlene B. Tilton, Gerald T. Ankley, Kathleen M. Jensen, Kendra N. Dean, Ashley R. Kittelson, Daniel L. Villeneuve, Alexander R. Cole, Brett R. Blackwell
Publikováno v:
Aquat Toxicol
Exposure to certain anthropogenic chemicals can inhibit the activity to cytochrome P450 aromatase (CYP19) in fishes leading to decreased plasma 17β-estradiol (E2), plasma vitellogenin (VTG), and egg production. Reproductive dysfunction resulting fro
Autor:
Jenna E. Cavallin, Gerald T. Ankley, Anthony L. Schroeder, Eric C. Randolph, Michael D. Kahl, Chad A. Blanksma, Daniel L. Villeneuve, Shane T. Poole, Patricia A. Kosian, Kellie A. Fay, Kathleen M. Jensen, Dries Knapen, Brett R. Blackwell, Lucia Vergauwen
Publikováno v:
Environmental Toxicology and Chemistry. 36:2942-2952
Inflation of the posterior and/or anterior swim bladder are processes previously demonstrated to be thyroid-hormone regulated. We investigated whether inhibition of deiodinases, which convert thyroxine (T4) to the more biologically-active form, 3,5,3
Autor:
Nancy D. Denslow, Quincy Teng, John M. Davis, Jason P. Berninger, Alvine C. Mehinto, Dalma Martinović-Weigelt, Kathleen M. Jensen, Drew R. Ekman, Carlie A. LaLone, Michael D. Kahl, Gerald T. Ankley, Evan Eid, Elizabeth J. Durhan, Daniel L. Villeneuve, Timothy W. Collette
Publikováno v:
Toxicological Sciences. 156:344-361
Cyclooxygenase (COX) inhibitors are ubiquitous in aquatic systems and have been detected in fish tissues. The exposure of fish to these pharmaceuticals is concerning because COX inhibitors disrupt the synthesis of prostaglandins (PGs), which modulate