Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Michael D. Hebert"'
Publikováno v:
Biology Open, Vol 12, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/80db8bb591464f84ad3ec08b175183a0
Autor:
Jerry D. Monroe, Satya A. Moolani, Elvin N. Irihamye, Katheryn E. Lett, Michael D. Hebert, Yann Gibert, Michael E. Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The monofunctional platinum(II) complex, phenanthriplatin, acts by blocking transcription, but its regulatory effects on long-noncoding RNAs (lncRNAs) have not been elucidated relative to traditional platinum-based chemotherapeutics, e.g., c
Externí odkaz:
https://doaj.org/article/e55824703fa84bb4bb1566c8e9a7f0a8
Publikováno v:
Biology Open, Vol 11, Iss 7 (2022)
The nuclear factor-Kappa B (NF-κB) pathway is a crucial mediator of inflammatory signaling. Aberrant activation of NF-κB is associated with several disorders including preeclampsia (PE). Many regulators of the NF-κB pathway have been identified, i
Externí odkaz:
https://doaj.org/article/939ef360516e49c79d3ba07615413738
Publikováno v:
Biology Open, Vol 9, Iss 10 (2020)
The Cajal body (CB) is a subnuclear domain that participates in the biogenesis of many different types of ribonucleoproteins (RNPs), including small nuclear RNPs (snRNPs), small Cajal body-specific RNPs (scaRNPs) and telomerase. Most scaRNAs, the RNA
Externí odkaz:
https://doaj.org/article/34fcc0ef68024542aa349036fb86ae50
Publikováno v:
Biology Open, Vol 6, Iss 9, Pp 1342-1354 (2017)
Many ribonucleoproteins (RNPs), which are comprised of noncoding RNA and associated proteins, are involved in essential cellular processes such as translation and pre-mRNA splicing. One class of RNP is the small Cajal body-specific RNP (scaRNP), whic
Externí odkaz:
https://doaj.org/article/42b851a613c3450d98e3c4b07a3c6f17
Publikováno v:
Biology Open, Vol 8, Iss 3 (2019)
The most common types of modification in human rRNA are pseudouridylation and 2′-O ribose methylation. These modifications are performed by small nucleolar ribonucleoproteins (snoRNPs) which contain a guide RNA (snoRNA) that base pairs at specific
Externí odkaz:
https://doaj.org/article/ccac7f6a8f6b405f9bb1d4f35200b660
Autor:
Aaron R. Poole, Michael D. Hebert
Publikováno v:
Biology Open, Vol 5, Iss 6, Pp 726-735 (2016)
Telomerase is a ribonucleoprotein comprising telomerase RNA and associated proteins. The formation of the telomerase holoenzyme takes place in the Cajal body (CB), a subnuclear domain that participates in the formation of ribonucleoproteins. CBs also
Externí odkaz:
https://doaj.org/article/6f50a7a56ac7421798259ee26a41a7c9
Publikováno v:
Biology Open, Vol 7, Iss 9 (2018)
Small Cajal body-specific RNAs (scaRNAs) are part of small Cajal body-specific ribonucleoproteins (scaRNPs) that modify small nuclear RNA (snRNA) in Cajal bodies (CBs). Several scaRNAs (scaRNA 2, 9 and 17) have been found to generate smaller, nucleol
Externí odkaz:
https://doaj.org/article/93ca2d1b4af44ac0b3d0a6cff99922c0
Publikováno v:
Biology Open, Vol 7, Iss 8 (2018)
Ribosomes can be heterogeneous, and the major contributor to ribosome heterogeneity is variation in rRNA modification. There are two major types of rRNA modification, pseudouridylation and ribose methylation. In humans, the majority of these rRNA mod
Externí odkaz:
https://doaj.org/article/6e5dd44b86a14581bfe453aa7f1d07ce
Autor:
Isioma I. Enwerem, Venkatramreddy Velma, Hanna J. Broome, Marija Kuna, Rowshan A. Begum, Michael D. Hebert
Publikováno v:
Biology Open, Vol 3, Iss 4, Pp 240-249 (2014)
Spliceosomal small nuclear ribonucleoproteins (snRNPs) are enriched in the Cajal body (CB). Guide RNAs, known as small Cajal body-specific RNAs (scaRNAs), direct modification of the small nuclear RNA (snRNA) component of the snRNP. The protein WRAP53
Externí odkaz:
https://doaj.org/article/681dcc3fcada465ea08188c1f3d93b65