Výsledky vyhledávání - "Michael D. Hadjidaniel"

Akademický článek

Bisulfite Conversion of DNA: Performance Comparison of Different Kits and Methylation Quantitation of Epigenetic Biomarkers that Have the Potential to Be Used in Non-Invasive Prenatal Testing.

Autor: Chrysanthia A Leontiou, Michael D Hadjidaniel, Petros Mina, Pavlos Antoniou, Marios Ioannides, Philippos C Patsalis

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135058 (2015)

Epigenetic alterations, including DNA methylation, play an important role in the regulation of gene expression. Several methods exist for evaluating DNA methylation, but bisulfite sequencing remains the gold standard by which base-pair resolution of

Externí odkaz: https://doaj.org/article/3c333e59b450416190cc9e0e3dd346f5

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Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma

Autor: Alan L. Epstein, Hiroyuki Shimada, Michael D. Hadjidaniel, Babak Moghimi, G. Esteban Fernandez, Randall Y. Chan, Michael A. Sheard, Sakunthala Muthugounder, Shahab Asgharzadeh, Shilpa Shahani, Rebekah J. Kennedy, Soheila Shirinbak, Muller Fabbri, Long T. Hung

Publikováno v: Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 10, Iss 1 (2021)

Immune checkpoint therapy has resulted in minimal clinical response in many pediatric cancers. We sought to understand the influence of immune checkpoint inhibition using anti-PD-1 and anti-CTLA-4 antibodies individually, in combination, and after ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37f7e389a3ac13dd41b174323772296
https://doi.org/10.1080/2162402x.2020.1838140

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Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC

Autor: Lucia Borriello, Soheila Shirinbak, Michael D. Hadjidaniel, Rebekah J. Kennedy, Hiroshi Iwakura, Hiroyuki Shimada, Takashi Akamizu, Sakunthala Muthugounder, Richard Sposto, Jemily Malvar, Shahab Asgharzadeh, Long T. Hung, Randall Y. Chan, Rie Nakata, Yves A. DeClerck, Michael A. Sheard

Publikováno v: Oncotarget

// Michael D. Hadjidaniel 1, * , Sakunthala Muthugounder 1, * , Long T. Hung 1, * , Michael A. Sheard 1 , Soheila Shirinbak 1 , Randall Y. Chan 1, 3 , Rie Nakata 1 , Lucia Borriello 1 , Jemily Malvar 1 , Rebekah J. Kennedy 1 , Hiroshi Iwakura 2 , Tak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f5a13887699d9c2a85b8b827bde6ca
https://doi.org/10.18632/oncotarget.21066

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MeDIP combined with in-solution targeted enrichment followed by NGS: Inter-individual methylation variability of fetal-specific biomarkers and their implementation in a proof of concept study for NIPT

Autor: George Koumbaris, Kyriakos Tsangaras, Philippos C. Patsalis, Charalambos Loizides, Carolina Sismani, Marios Ioannides, Petros Mina, Skevi Kyriacou, Elena Kypri, Maria Neofytou, Achilleas Achilleos, Anna Keravnou, Michael D. Hadjidaniel

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0199010 (2018)
PLOS ONE

DNA methylation is the most characterized epigenetic process exhibiting stochastic variation across different tissues and individuals. In non-invasive prenatal testing (NIPT) fetal specific methylated regions can potentially be used as biomarkers for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140c4cd09e93962301982f32fc4f6fd1
http://europepmc.org/articles/PMC5995407?pdf=render

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Whole-genome fetal and maternal DNA methylation analysis using MeDIP-NGS for the identification of differentially methylated regions

Autor: Skevi Kyriakou, Elena Kypri, Philippos C. Patsalis, Anna Keravnou, Charalambos Loizides, Maria Neofytou, Marios Ioannides, Elisavet A. Papageorgiou, Achilleas Achilleos, Michael D. Hadjidaniel, Carolina Sismani, Petros Mina, Kyriakos Tsangaras, Pavlos Antoniou, George Koumbaris

Publikováno v: Genetics Research

SummaryDNA methylation is an epigenetic marker that has been shown to vary significantly across different tissues. Taking advantage of the methylation differences between placenta-derived cell-free DNA and maternal blood, several groups employed diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f019df751e9270e078ae35594b7f413
https://pubmed.ncbi.nlm.nih.gov/27834155

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Antagonism of Cytotoxic Chemotherapy in Neuroblastoma Cell Lines by 13-cis-Retinoic Acid Is Mediated by the Antiapoptotic Bcl-2 Family Proteins

Autor: Michael D. Hadjidaniel, C. Patrick Reynolds

Publikováno v: Molecular Cancer Therapeutics. 9:3164-3174

13-cis-Retinoic acid (13-cis-RA) is given at completion of cytotoxic therapy to control minimal residual disease in neuroblastoma. We investigated the effect of combining 13-cis-RA with cytotoxic agents employed in neuroblastoma therapy using a panel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158426dadd6d411e5dfa6a6d5e1e5541
https://doi.org/10.1158/1535-7163.mct-10-0078

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Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy

Publikováno v: JNCI: Journal of the National Cancer Institute. 107

Background: How exosomic microRNAs (miRNAs) contribute to the development of drug resistance in the context of the tumor microenvironment has not been previously described in neuroblastoma (NBL). Methods: Coculture experiments were performed to asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a80b21724095b708d4b57a8da8a6fca
https://doi.org/10.1093/jnci/djv135

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Bisulfite Conversion of DNA: Performance Comparison of Different Kits and Methylation Quantitation of Epigenetic Biomarkers that Have the Potential to Be Used in Non-Invasive Prenatal Testing

Autor: Philippos C. Patsalis, Marios Ioannides, Pavlos Antoniou, Chrysanthia A. Leontiou, Petros Mina, Michael D. Hadjidaniel

Publikováno v: PLOS ONE
PLoS ONE, Vol 10, Iss 8, p e0135058 (2015)
PLoS ONE

Introduction Epigenetic alterations, including DNA methylation, play an important role in the regulation of gene expression. Several methods exist for evaluating DNA methylation, but bisulfite sequencing remains the gold standard by which base-pair r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df16cb4324ea719b0881d7c258948a32

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The Epigenome View: An Effort towards Non-Invasive Prenatal Diagnosis

Autor: George Koumbaris, Elena Kypri, Philippos C. Patsalis, Elisavet A. Papageorgiou, Michael D. Hadjidaniel

Publikováno v: Genes
Genes, Vol 5, Iss 2, Pp 310-329 (2014)

Epigenetic modifications have proven to play a significant role in cancer development, as well as fetal development. Taking advantage of the knowledge acquired during the last decade, great interest has been shown worldwide in deciphering the fetal e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299e7f96ad72005eb861a3492f74abeb
https://pubmed.ncbi.nlm.nih.gov/24722507

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