Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael D. Elftman"'
Autor:
Michael D. Elftman, Christiane E. Wobus, Abimbola O. Kolawole, Joana Rocha-Pereira, Johan Neyts
Publikováno v:
Antiviral Research. 132:46-49
The recently developed human norovirus (HuNoV) B cell culture and mouse models hold promise for drug discovery and development but their suitability for antiviral studies has not been assessed. We demonstrate the inhibitory effect of the nucleoside a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e789e281fb48087a8389879d08d58a
https://doi.org/10.1016/j.antiviral.2016.05.011
https://doi.org/10.1016/j.antiviral.2016.05.011
Noroviruses are highly prevalent, positive-sense RNA viruses that are transmitted by the fecal–oral route and infect the gastrointestinal tract of their host. Human noroviruses cause the majority of acute nonbacterial gastroenteritis infections wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba66fb21e7162ecf3cdb86bef59a00d
https://doi.org/10.1016/b978-0-12-802241-2.00019-5
https://doi.org/10.1016/b978-0-12-802241-2.00019-5
Autor:
Jennifer C. Mellinger, Christopher C. Norbury, Michael D. Elftman, M.E. Truckenmiller, John Hunzeker, Robert H. Bonneau
Publikováno v:
The Journal of Immunology. 184:1867-1875
The systemic elevation of psychological stress-induced glucocorticoids strongly suppresses CD8+ T cell immune responses resulting in diminished antiviral immunity. However, the specific cellular targets of stress/glucocorticoids, the timing of exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c40baec1121dad1a4c0bcbcb75bf324
https://doi.org/10.4049/jimmunol.0902469
https://doi.org/10.4049/jimmunol.0902469
Publikováno v:
Immunology. 122:279-290
Dendritic cells (DC) play a critical role in initiating and directing adaptive immune responses against pathogens and tumours. Immature DC are thought to act as sentinels in peripheral tissues where their main function is to capture antigen at sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967cd8a9796f1a78ea96158b05b09b5a
https://doi.org/10.1111/j.1365-2567.2007.02637.x
https://doi.org/10.1111/j.1365-2567.2007.02637.x
Autor:
Holly Turula, Michael D. Elftman, Abimbola O. Kolawole, Christiane E. Wobus, Chenchen Yu, Mariam B. Gonzalez-Hernandez
Publikováno v:
Journal of virology. 90(3)
A critical early step in murine norovirus (MNV) pathogenesis is crossing the intestinal epithelial barrier to reach the target cells for replication, i.e., macrophages, dendritic cells, and B cells. Our previous work showed that MNV replication decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0b655e28f747eda4f6e10c59d5b1e4
https://pubmed.ncbi.nlm.nih.gov/26581993
https://pubmed.ncbi.nlm.nih.gov/26581993
Publikováno v:
Infection and Immunity. 72:1409-1422
In cattle and other ruminants, infection with the intracellular pathogenMycobacterium aviumsubsp.paratuberculosisresults in a granulomatous enteritis (Johne's disease) that is often fatal. The key features of host immunity toM. aviumsubsp.paratubercu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4157d0da0aeebd03e5ff51215f6251f5
https://doi.org/10.1128/iai.72.3.1409-1422.2004
https://doi.org/10.1128/iai.72.3.1409-1422.2004
Autor:
Michael D. Elftman, Mariam B. Gonzalez-Hernandez, Cheryl Perkins, Christiane E. Wobus, Nobuhiko Kamada, Kenneth S Henderson, Gabriel Núñez
Dendritic cells (DCs) are permissive to murine norovirus (MNV) infection in vitro and in vivo. However, their roles during infection in vivo are not well defined. To determine the role of DCs during infection, conventional DCs were depleted from CD11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f2029073c4280f9f27f092a4f7d47f
https://europepmc.org/articles/PMC3749526/
https://europepmc.org/articles/PMC3749526/
Autor:
Michael D. Elftman, Jennifer C. Mellinger, M.E. Truckenmiller, John Hunzeker, Christopher C. Norbury, Michael F. Princiotta, Robert H. Bonneau
Protracted psychological stress elevates circulating glucocorticoids, which can suppress CD8+ T cell-mediated immunity, but the mechanisms are incompletely understood. Dendritic cells (DCs), required for initiating CTL responses, are vulnerable to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636c68af97864d34ed096c48f7c2ec55
https://europepmc.org/articles/PMC3701459/
https://europepmc.org/articles/PMC3701459/
Autor:
Michael D. Elftman, Guilherme J. M. Rosa, Juliana Pérez Laspiur, Christopher J. Colvin, Paul M. Coussens
Publikováno v:
Infection and immunity. 71(11)
A bovine-specific cDNA microarray system was used to compare gene expression profiles of peripheral blood mononuclear cells (PBMCs) from control uninfected ( n = 4) and Johne's disease-positive ( n = 6) Holstein cows. Microarray experiments were desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcc60174485a6c44f63188af994e875
https://pubmed.ncbi.nlm.nih.gov/14573671
https://pubmed.ncbi.nlm.nih.gov/14573671
Autor:
Miriam Weber-Nielsen, Sue Sipkovsky, Rachael Kruska, Lan Xiao, Robert G. Halgren, Michael J. VandeHaar, Michael D. Elftman, Robert J. Tempelman, Paul M. Coussens, Steven P. Suchyta
Publikováno v:
Physiological genomics. 16(1)
A cDNA microarray resource enhanced for transcripts specific to the bovine mammary gland (BMAM) has been developed and used in pilot studies to examine gene expression profiles in the mammary gland. One goal driving development of this resource was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9717c4d18353de2e31f13b54c4f512d
https://pubmed.ncbi.nlm.nih.gov/14559974
https://pubmed.ncbi.nlm.nih.gov/14559974