Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael D. Duffield"'
Autor:
Pinar Coskun, Damien J. Keating, Michael D. Duffield, Claire F. Jessup, William C. Mobley, Sean L. McGee, Victor L. J. Tybulewicz, Tertius Hough, Pavel V. Belichenko, João Fadista, Amanda J Genders, Penelope Coates, Melanie April Pritchard, Jorge Busciglio, Ann Becker, Elizabeth M. C. Fisher, Heshan Peiris, Ross Laybutt
Publikováno v:
Diabetes. 64:A1-A100
Autor:
Xin-Fu Zhou, Tim Chataway, Yoon Lim, Damien J. Keating, Kimberly D. Mackenzie, Michael D. Duffield
Publikováno v:
Cellular signalling. 35
Huntingtin-associated protein 1 (HAP1) was initially identified as a binding partner of huntingtin, mutations in which underlie Huntington's disease. Subcellular localization and protein interaction data indicate that HAP1 may be important in vesicle
Autor:
Lucy Phillips, Ee Hiok Teo, Kimberly D. Mackenzie, Michael D. Duffield, Mark P. Zanin, Damien J. Keating, Xin-Fu Zhou, Heshan Peiris
Publikováno v:
The Journal of Physiology. 592:1505-1518
Key points Huntingtin-associated protein 1 (HAP1) is expressed in neurons and endocrine cells, in which it is thought to regulate vesicle trafficking. HAP1 is a binding partner of the Huntington's disease (HD)-causing protein huntingtin, and binding
Autor:
Adrian Cuda Banda Meedeniya, Nick J. Spencer, TC Sia, Michael D. Duffield, Simon J. H. Brookes, Damien J. Keating, David Wattchow, Ravinarayan Raghupathi, Leah Zelkas
Publikováno v:
The Journal of Physiology. 591:5959-5975
The major source of serotonin (5-HT) in the body is the enterochromaffin (EC) cells lining the intestinal mucosa of the gastrointestinal tract. Despite the fact that EC cells synthesise ∼95% of total body 5-HT, and that this 5-HT has important para
Autor:
Ann Becker, Pinar Coskun, Petr Volkov, Vinder Kashmir, Nikolay Oskolkov, Claire F. Jessup, Heshan Peiris, Michael T. Ryan, William C. Mobley, Amanda J Genders, Nicholas M. Morton, Alyce M. Martin, D. Ross Laybutt, Michael D. Duffield, Michael A. Cousin, João Fadista, Jeng Yie Chan, Sean L. McGee, Leif Groop, Alexandros C. Kokotos, Victor L. J. Tybulewicz, Tertius Hough, Elizabeth M. C. Fisher, Melanie April Pritchard, Jorge Busciglio, P. Toby Coates, Roderick N. Carter, Charlotte Ling, Madiha Saiedi, Sijun Yang, Pavel V. Belichenko, Damien J. Keating
Publikováno v:
Peiris, H; Duffield, MD; Fadista, J; Jessup, CF; Kashmir, V; Genders, AJ; et al.(2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genetics, 12(5). doi: 10.1371/journal.pgen.1006033. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/69g1d108
Peiris, H, Duffield, M D, Fadista, J, Jessup, C F, Kashmir, V, Genders, A J, McGee, S L, Martin, A M, Saiedi, M, Morton, N, Carter, R, Cousin, M A, Kokotos, A, Oskolkov, N, Volkov, P, Hough, T A, Fisher, E M C, Tybulewicz, V L J, Busciglio, J, Coskun, P E, Becker, A, Belichenko, P V, Mobley, W C, Ryan, M T, Chan, J Y, Laybutt, D R, Coates, P T, Yang, S, Ling, C, Groop, L, Pritchard, M A & Keating, D J 2016, ' A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in Type 2 diabetes ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1006033
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
PLoS Genetics
Peiris, H, Duffield, M D, Fadista, J, Jessup, C F, Kashmir, V, Genders, A J, McGee, S L, Martin, A M, Saiedi, M, Morton, N, Carter, R, Cousin, M A, Kokotos, A, Oskolkov, N, Volkov, P, Hough, T A, Fisher, E M C, Tybulewicz, V L J, Busciglio, J, Coskun, P E, Becker, A, Belichenko, P V, Mobley, W C, Ryan, M T, Chan, J Y, Laybutt, D R, Coates, P T, Yang, S, Ling, C, Groop, L, Pritchard, M A & Keating, D J 2016, ' A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in Type 2 diabetes ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1006033
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
PLoS Genetics
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a79e00f46b9b13910b1e47b75ca457
http://www.escholarship.org/uc/item/69g1d108
http://www.escholarship.org/uc/item/69g1d108
Autor:
Kimberly D. Mackenzie, Xin-Fu Zhou, Feng Guo, Michael D. Duffield, Yoon Lim, Amanda L. Lumsden, Damien J. Keating, Tim Chataway
Huntingtin-associated protein-1 (HAP1) is involved in intracellular trafficking, vesicle transport, and membrane receptor endocytosis. However, despite such diverse functions, the role of HAP1 in the synaptic vesicle (SV) cycle in nerve terminals rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf7bdbf75a2b02df414dd6d3c46171d
https://hdl.handle.net/11541.2/123470
https://hdl.handle.net/11541.2/123470
Autor:
Raman Kumar, Kim Abbott, Jozef Gecz, Eric Haan, Melanie Bahlo, Joshua A. Woenig, Nicholas J.C. Smith, Mark A. Corbett, Joseph G. Gleeson, Koko Moriya, Joris A. Veltman, Peer Arts, Sabine Gijsen, Michael G. Harbord, C Tan, Michael D. Duffield, Lachlan A. Jolly, Toshihiko Utsumi, Damien J. Keating, Katherine R. Smith, Alison G. Compton, Nienke Wieskamp, Michael Kwint, Alexander Hoischen
Publikováno v:
Human Molecular Genetics, 24, 7, pp. 2000-10
Human Molecular Genetics, 24, 2000-10
Human Molecular Genetics, 24, 2000-10
Item does not contain fulltext We report siblings of consanguineous parents with an infantile-onset neurodegenerative disorder manifesting a predominant sensorimotor axonal neuropathy, optic atrophy and cognitive deficit. We used homozygosity mapping
Publikováno v:
The Journal of Physiology. 568:5-12
Transition metals block the muscle Cl− channel ClC-1, which belongs to a large family of double-barreled Cl− channels and transporters. In the Torpedo Cl− channel ClC-0, Zn2+ block is closely related to the common gating mechanism that opens an
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112466 (2014)
PLoS ONE
PLoS ONE
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In mammal
In mammal
Autor:
Murray L. Whitelaw, Jeffrey J. Gorman, Nathan R. Scrimgeour, Johana Chicher, Michael D. Duffield, Daniel J. Peet, Mark L. Dallas, Jonathan M. Gleadle, Sarah Karttunen, Wai Li Lim, Chris Peers, Lauren Squires, Grigori Y. Rychkov, Keyur A. Dave, Jason L. Scragg
Publikováno v:
Journal of Cell Science.
Factor Inhibiting HIF (FIH) is an oxygen-dependent asparaginyl hydroxylase that regulates the hypoxia-inducible factors (HIFs). Several proteins containing ankyrin repeat domains have been characterised as substrates of FIH, although there is little