Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael D. DuVall"'
Publikováno v:
Regulatory Toxicology and Pharmacology. 60:40-45
Cynomolgus monkeys are an important and widely used species in preclinical toxicology studies. During the in-life phase of study, body weight effects may be indicative of toxicity; however, trends in body weight and body weight variability are often
Autor:
Timea Kovacs, Michael D. DuVall, Eric J. Sorscher, Marina Mazur, Gavin M. Braunstein, Hui Wen, Joseph A. Maddry, John P. Clancy, Erik M. Schwiebert, Heather Greer, Julie R. Jones, Charles J. Venglarik, Eleanor Bates
Publikováno v:
Biochemistry. 42:13241-13249
Recent interest in nucleotides and related agents as part of clinical trials in cystic fibrosis (CF) therapy have elicited efforts to identify novel compounds capable of activating transepithelial chloride (Cl(-)) transport in CF cells and tissues. F
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 275:L1127-L1133
Active Na+ transport by alveolar epithelial cells has been demonstrated to contribute significantly to alveolar fluid clearance. However, the contribution of transepithelial Cl− movement to the reabsorption of isosmotic fluid across the alveolar ep
Autor:
Catherine M. Fuller, Michael D. DuVall, Dale J. Benos, James K. Bubien, Trudy L. Cornwell, A. L. Bradford
Publikováno v:
American Journal of Physiology-Cell Physiology. 275:C702-C710
Two independent signal transduction pathways regulate lymphocyte amiloride-sensitive sodium channels (ASSCs), one utilizing cAMP as a second messenger and the other utilizing a GTP-binding protein. This implies that two plasma membrane receptors play
Publikováno v:
American Journal of Physiology-Cell Physiology. 274:C1417-C1423
We examined the effect of peroxynitrite (ONOO−) on the cloned rat epithelial Na+ channel (αβγ-rENaC) expressed in Xenopusoocytes. 3-Morpholinosydnonimine (SIN-1) was used to concurrently generate nitric oxide (⋅ NO) and superoxide ([Formula: s
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 274:L369-L377
We examined the mechanisms by which nitric oxide (⋅ NO) decreased vectorial Na+transport across confluent monolayers of rat alveolar type II (ATII) cells grown on permeable supports. Amiloride (10 μM) applied to the apical side of monolayers inhib
Autor:
Jian-Yun Dong, Co-Investigators: Raymond A. Frizzell, James J. Logan, Principal Investigators: Eric J. Sorscher, P. L. Feigner, Lynn Walker, Raymond K. Lyrene, Sadis Matalon, Brian J. Wiatrak, Michael D. DuVall, Investigators: Zsuzsa Bebok
Publikováno v:
Human Gene Therapy. 5:1259-1277
SCIENTIFIC ABSTRACT Cystic fibrosis (CF) is a common, lethal, inherited disease among Caucasian children and young adults. While the pathophysiology of CF includes many organ systems (e.g., gastrointestinal, reproductive, endocrine) the predominant c
Publisher Summary The chapter presents a study on inhibition of vectorial sodium ion (Na + ) transport across alveolar epithelial cells by nitrogen–oxygen reactive species. The chapter presents a review on the interaction of nitric oxide with other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711baf988680b542eab8ec65c2153a82
https://doi.org/10.1016/s0070-2161(08)60961-2
https://doi.org/10.1016/s0070-2161(08)60961-2
Publikováno v:
The American journal of physiology. 275(5)
We examined the effects of H2O2on Cl−secretion across human colonic T84 cells grown on permeable supports and mounted in modified Ussing chambers. Forskolin-induced short-circuit current, a measure of Cl−secretion, was inhibited in a concentratio
Autor:
Catherine M. Fuller, Holly K. Patton, Hong Long Ji, Dale J. Benos, Michael D. DuVall, Cynthia Lyn Satterfield
Publikováno v:
The American journal of physiology. 274(2)
We have isolated a niflumic acid-insensitive, Ca2+-activated Cl−channel (CaCC) from bovine trachea that migrates at 38 kDa (p38) on reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. However, a cloned CaCC isolated from a tracheal