Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Michael D. Cahalan"'
Autor:
Rían W. Manville, Ryan F. Yoshimura, Andriy V. Yeromin, Derk Hogenkamp, Jennifer van der Horst, Angel Zavala, Sonia Chinedu, Grey Arena, Emma Lasky, Mark Fisher, Christopher R. Tracy, Shivashankar Othy, Thomas A. Jepps, Michael D. Cahalan, Geoffrey W. Abbott
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects. Here, we screened 1444 plant extracts, prepared primarily from native sp
Externí odkaz:
https://doaj.org/article/5bae3235538b444ea2fc2392f2ec6cbc
Autor:
Hamza Atcha, Amit Jairaman, Jesse R. Holt, Vijaykumar S. Meli, Raji R. Nagalla, Praveen Krishna Veerasubramanian, Kyle T. Brumm, Huy E. Lim, Shivashankar Othy, Michael D. Cahalan, Medha M. Pathak, Wendy F. Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and
Externí odkaz:
https://doaj.org/article/30c02e56c3ed471195876b3588e37e70
Autor:
Jonathan Skupsky, Subrata Sabui, Michael Hwang, Manando Nakasaki, Michael D. Cahalan, Hamid M. Said
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 557-567 (2020)
Background & Aims: Biotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis. We previously reported that biotin deficiency also
Externí odkaz:
https://doaj.org/article/897871eabba44ae3a7ac1feeb4464806
Autor:
Nicole M. Wakida, Veronica Gomez-Godinez, Huayan Li, Jessica Nguyen, Edward K. Kim, Joseph L. Dynes, Shivashankar Othy, Alice L. Lau, Peng Ding, Linda Shi, Christopher Carmona, Leslie M. Thompson, Michael D. Cahalan, Michael W. Berns
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The changes in intracellular calcium concentration ([Ca2+]) following laser-induced cell injury in nearby cells were studied in primary mouse astrocytes selectively expressing the Ca2+ sensitive GFAP-Cre Salsa6f fluorescent tandem protein, in an Ast1
Externí odkaz:
https://doaj.org/article/ddebd47f3e8448bd8356530a827439ba
Autor:
Laura L. McIntyre, Scott A. Greilach, Shivashankar Othy, Ilse Sears-Kraxberger, Brian Wi, Julio Ayala-Angulo, Estelle Vu, Quan Pham, Jorge Silva, Kody Dang, Fady Rezk, Oswald Steward, Michael D. Cahalan, Thomas E. Lane, Craig M. Walsh
Publikováno v:
Neurobiology of Disease, Vol 140, Iss , Pp 104868- (2020)
Multiple sclerosis (MS) is a chronic, inflammatory autoimmune disease that affects the central nervous system (CNS) for which there is no cure. In MS, encephalitogenic T cells infiltrate the CNS causing demyelination and neuroinflammation; however, l
Externí odkaz:
https://doaj.org/article/0267cb0c0c94439cba4bb8df0b7a67b2
Autor:
Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan
Publikováno v:
eLife, Vol 11 (2022)
The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis. Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD
Externí odkaz:
https://doaj.org/article/69b87460172149e083d3a847b9a787f6
Autor:
Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan
Publikováno v:
Alzheimer's & Dementia. 18:1765-1778
The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on microglial responses to AD pathology remains unknown. Chimeric AD and wild-type mice were
Autor:
Jessica L. Bolton, Annabel K. Short, Shivashankar Othy, Cassandra L. Kooiker, Manlin Shao, Benjamin G. Gunn, Jaclyn Beck, Xinglong Bai, Stephanie M. Law, Julie C. Savage, Jeremy J. Lambert, Delia Belelli, Marie-Ève Tremblay, Michael D. Cahalan, Tallie Z. Baram
Publikováno v:
Alcohol. 109:87-88
Autor:
Tobias X Dong, Shivashankar Othy, Milton L Greenberg, Amit Jairaman, Chijioke Akunwafo, Sabrina Leverrier, Ying Yu, Ian Parker, Joseph L Dynes, Michael D Cahalan
Publikováno v:
eLife, Vol 6 (2017)
Ca2+ influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here, we show that inhibition of Orai1 channel activity increases average cell velocities by reducing
Externí odkaz:
https://doaj.org/article/c43576b4857b402ca2edd7c7540ca0b0
Autor:
Tobias X Dong, Shivashankar Othy, Amit Jairaman, Jonathan Skupsky, Angel Zavala, Ian Parker, Joseph L Dynes, Michael D Cahalan
Publikováno v:
eLife, Vol 6 (2017)
Calcium is an essential cellular messenger that regulates numerous functions in living organisms. Here, we describe development and characterization of ‘Salsa6f’, a fusion of GCaMP6f and tdTomato optimized for cell tracking while monitoring cytos
Externí odkaz:
https://doaj.org/article/9b0f397a22cd45589cafd282c3004bf4