Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Michael D. Brodt"'
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101615- (2022)
Introduction: Knowledge of bone structure-function relationships in mice has been based on relatively small sample sets that limit generalizability. We sought to investigate structure-function relationships of long bones from a large population of ge
Externí odkaz:
https://doaj.org/article/797464590eae4827812ee6b482256b7a
Autor:
Wei Zou, Nidhi Rohatgi, Jonathan R Brestoff, Yan Zhang, Erica L Scheller, Clarissa S Craft, Michael D Brodt, Nicole Migotsky, Matthew J Silva, Charles A Harris, Steven L Teitelbaum
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008244 (2019)
Berardinelli-Seip congenital generalized lipodystrophy is associated with increased bone mass suggesting that fat tissue regulates the skeleton. Because there is little mechanistic information regarding this issue, we generated "fat-free" (FF) mice c
Externí odkaz:
https://doaj.org/article/3f85769dcd8146f293a5b9cf73c78f3b
Autor:
Ingrid Braenne, Christopher J Chermside-Scabbo, Matthew J. Silva, Michael D. Brodt, Taylor L Harris, Charles R. Farber, Bo Zhang
Publikováno v:
J Bone Miner Res
Mechanical loading is a potent strategy to induce bone formation, but with aging, the bone formation response to the same mechanical stimulus diminishes. Our main objectives were to (i) discover the potential transcriptional differences and (ii) comp
Autor:
Chun Wang, L. Yuan, Matthew J. Silva, Michael D. Brodt, Yousef Abu-Amer, Tong Yang, Jie Shen, Kai Sun, H. Hu, Jianqiu Xiao, Gabriel Mbalaviele, Yael Alippe, D. Hao
Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM- mediated pore formation can compromise the integrity of the plasma me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033eb685aa388c0b3336f9a2d7a1f49c
https://doi.org/10.1101/2021.11.29.470391
https://doi.org/10.1101/2021.11.29.470391
Autor:
Ramya Palaniappan, Matthew J. Silva, Michael D. Brodt, Lisa Y. Lawson, Nicole Migotsky, Christopher J Chermside-Scabbo
Publikováno v:
J Bone Miner Res
Wnt signaling is critical to many aspects of skeletal regulation, but the importance of Wnt ligands in the bone anabolic response to mechanical loading is not well established. Recent transcriptome profiling studies by our laboratory and others show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77006ffa34ffc228dcbb6b16ed3947c
https://europepmc.org/articles/PMC8770559/
https://europepmc.org/articles/PMC8770559/
Autor:
Erica L. Scheller, James M. Cheverud, Karen Steger-May, Jeremy D. Eekhoff, Tarpit K. Patel, Michael D. Brodt, Matthew J. Silva, Jane P. Kenney-Hunt
Publikováno v:
Journal of Bone and Mineral Research. 34:711-725
Obesity is generally protective against osteoporosis and bone fracture. However, recent studies indicate that the influence of obesity on the skeleton is complex and can be detrimental. We evaluated the effects of a high-fat, obesogenic diet on the f
Autor:
Michael D. Brodt, Lisa Y. Lawson, Nicole Migotsky, Ramya Palaniappan, Matthew J. Silva, Christopher J Chermside-Scabbo
Wnt signaling is critical to many aspects of skeletal regulation, but the importance of Wnt ligands in adult bone homeostasis and the anabolic response to mechanical loading is not well documented. We inhibited Wnt ligand secretion in adult (5-mo) mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78cb8bc20734259ce9dcc3d9050db779
https://doi.org/10.1101/2021.03.30.437737
https://doi.org/10.1101/2021.03.30.437737
Autor:
Michael D. Brodt, Peter J Delisser, Edmund Pickering, Matthew J. Silva, YuanTong Gu, Peter Pivonka
Publikováno v:
J Biomech
The murine tibia compression model, is the gold standard for studying bone adaptation due to mechanical loading in vivo. Currently, a key limitation of the experimental protocol and associated finite element (FE) models is that the exact load transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f88e72fbf0d4d2945806de9f82358bf
https://europepmc.org/articles/PMC7856106/
https://europepmc.org/articles/PMC7856106/
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071610275
Methods in Molecular Biology ISBN: 9781071610275
The purpose of this Chapter is to present a detailed description of methods for performing bone Micro-Computed Tomography (microCT) scanning and analysis. MicroCT is an x-ray imaging method capable of visualizing bone at the micro-structural scale, t