Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael D. Bright"'
Autor:
Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn, Anne J. Ridley
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-20 (2018)
Abstract Background Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not be
Externí odkaz:
https://doaj.org/article/ff58e5f3ece74db8839b003b8eba8180
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
Autor:
Alice C. Harnden, Owen A. Davis, Gary M. Box, Angela Hayes, Louise D. Johnson, Alan T. Henley, Alexis K. de Haven Brandon, Melanie Valenti, Kwai-Ming J. Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A. Pierrat, Rachel Talbot, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Selby de Klerk, Peter Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 66:5892-5906
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9094aa8cbb7b8cceb3273b677e3d3d9
https://doi.org/10.1021/acs.jmedchem.3c00155
https://doi.org/10.1021/acs.jmedchem.3c00155
Autor:
Owen A. Davis, Kwai-Ming J. Cheung, Alfie Brennan, Matthew G. Lloyd, Matthew J. Rodrigues, Olivier A. Pierrat, Gavin W. Collie, Yann-Vaï Le Bihan, Rosemary Huckvale, Alice C. Harnden, Ana Varela, Michael D. Bright, Paul Eve, Angela Hayes, Alan T. Henley, Michael D. Carter, P. Craig McAndrew, Rachel Talbot, Rosemary Burke, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Mirco Meniconi, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 65:8169-8190
To identify new chemical series with enhanced binding affinity to the BTB domain of B-cell lymphoma 6 protein, we targeted a subpocket adjacent to Val18. With no opportunities for strong polar interactions, we focused on attaining close shape complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f6c02b01eed5ce5ede7cf979780c4e
https://doi.org/10.1021/acs.jmedchem.1c02174
https://doi.org/10.1021/acs.jmedchem.1c02174
Autor:
Rosemary Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, Olivier A. Pierrat, Rachel Talbot, Gary M. Box, Alan T. Henley, Alexis K. de Haven Brandon, Albert E. Hallsworth, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Angela Hayes, Emma A. Gunnell, Alfie Brennan, Owen A. Davis, Louise D. Johnson, Selby de Klerk, Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder
Publikováno v:
Journal of Medicinal Chemistry. 65:8191-8207
The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies. Herein, we report the optimization of our previously reported benzimidazolone molecular glue-type degrader
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69d8cef8cdf04211cefb44860e5b55b
https://doi.org/10.1021/acs.jmedchem.1c02175
https://doi.org/10.1021/acs.jmedchem.1c02175
Autor:
Rob L. M. van Montfort, Kwai-Ming J. Cheung, L. Johnson, Mirco Meniconi, Florence I. Raynaud, P. Craig McAndrew, Rosemary Huckvale, Gavin W. Collie, Alan T. Henley, Olivier A. Pierrat, Emma Gunnell, Michael Carter, Matthew J. Rodrigues, Yann-Vaï Le Bihan, Mahad Gatti Iou, Matthew Garth Lloyd, Angela Hayes, Benjamin R. Bellenie, Rosemary Burke, Rachel Talbot, Olivia W. Rossanese, Michael D. Bright, Swen Hoelder, Owen Alexander Davis
Publikováno v:
Journal of Medicinal Chemistry
'Journal of Medicinal Chemistry ', vol: 64, pages: 17079-17097 (2021)
'Journal of Medicinal Chemistry ', vol: 64, pages: 17079-17097 (2021)
We describe the optimization of modestly active starting points to potent inhibitors of BCL6 by growing into a subpocket, which was occupied by a network of five stably bound water molecules. Identifying potent inhibitors required not only forming ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcc591a63ed4a3f1d0ac4656dc9e279
http://europepmc.org/articles/PMC8667045
http://europepmc.org/articles/PMC8667045
Autor:
Hannah Woodward, Kwai-Ming J. Cheung, Paolo Innocenti, L. Johnson, Benjamin R. Bellenie, Florence I. Raynaud, Olivia W. Rossanese, Sharon Gowan, Vladimir Kirkin, Michael D. Bright, Alan T. Henley, Gavin W. Collie, Selby de Klerk, Olivier A. Pierrat, Rachel Talbot, Michael Carter, Yann-Vaï Le Bihan, Angela Hayes, Matthew Garth Lloyd, Manjuan Liu, Swen Hoelder, Rosemary Burke, Erald Shehu, Ana Varela, Matthew J. Rodrigues, Owen Alexander Davis, P. Craig McAndrew, Kartika N. Shetty, Gary Box, Rob L. M. van Montfort
Publikováno v:
Journal of Medicinal Chemistry. 63:4047-4068
Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4650fa7cbb37e5c443ba8e108235c365
https://doi.org/10.1021/acs.jmedchem.9b02076
https://doi.org/10.1021/acs.jmedchem.9b02076
Autor:
Benjamin R, Bellenie, Kwai-Ming J, Cheung, Ana, Varela, Olivier A, Pierrat, Gavin W, Collie, Gary M, Box, Michael D, Bright, Sharon, Gowan, Angela, Hayes, Matthew J, Rodrigues, Kartika N, Shetty, Michael, Carter, Owen A, Davis, Alan T, Henley, Paolo, Innocenti, Louise D, Johnson, Manjuan, Liu, Selby, de Klerk, Yann-Vaï, Le Bihan, Matthew G, Lloyd, P Craig, McAndrew, Erald, Shehu, Rachel, Talbot, Hannah L, Woodward, Rosemary, Burke, Vladimir, Kirkin, Rob L M, van Montfort, Florence I, Raynaud, Olivia W, Rossanese, Swen, Hoelder
Publikováno v:
Journal of Medicinal Chemistry
Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b69bcc50adc7e246cbc1312a1fd83ac1
https://pubmed.ncbi.nlm.nih.gov/32275432
https://pubmed.ncbi.nlm.nih.gov/32275432
Autor:
Timothy C. Elston, Richard Allen, Anne J. Ridley, Klaus M. Hahn, Ritu Garg, Claudia Owczarek, Virginia Tajadura-Ortega, Aisyah Mohd-Noor, Michael D. Bright, Anita Grigoriadis, Samuel Kean
Publikováno v:
Tajadura-Ortega, V, Garg, R, Allen, R, Owczarek, C, Bright, M D, Kean, S, Mohd-Noor, A, Grigoriadis, A, Elston, T C, Hahn, K M & Ridley, A J 2018, ' An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration ', BMC Biology, vol. 16, no. 1, 29 . https://doi.org/10.1186/s12915-018-0489-4
BMC Biology, Vol 16, Iss 1, Pp 1-20 (2018)
BMC Biology
BMC Biology, Vol 16, Iss 1, Pp 1-20 (2018)
BMC Biology
Background Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not been carrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186e198f814722411fa93001da5ebe08
https://research-information.bris.ac.uk/ws/files/149448883/Tajadura_BMCBiol_18.pdf
https://research-information.bris.ac.uk/ws/files/149448883/Tajadura_BMCBiol_18.pdf
Autor:
Faith E. Davies, Gareth J. Morgan, Christopher P. Wardell, Daniel N. Itzhak, Michael D. Bright
Publikováno v:
Molecular and Cellular Biology
The unfolded protein response (UPR) remediates endoplasmic reticulum (ER) stress. IRE1, a component of the UPR, senses misfolded protein and cleaves XBP1 mRNA, which is ligated to code for the prosurvival transcription factor. IRE1 also cleaves other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17b94ed0126a64e33ea6e0bc96f2740
http://europepmc.org/articles/PMC4438243
http://europepmc.org/articles/PMC4438243
Publikováno v:
Journal of Cell Science. 125:6020-6029
Summary Phagocytosis is the force-dependent complex cellular process by which immune cells engulf particles. Although there has been considerable progress in understanding ligand-receptor-induced actin polymerisation in pushing the membrane around th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317b185bae97afa45d86fe86da022d3d
https://doi.org/10.1242/jcs.109561
https://doi.org/10.1242/jcs.109561