Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Michael D. Briggs"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. CRELD2 is an ER-stress regulated gene that has been implicated in the patho
Externí odkaz:
https://doaj.org/article/0b65843fcc6946a69ce958af80de19a6
Autor:
Dan J. Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G. Miles, Dimitra Tsompani, Robert M. Jackson, Michael D. Briggs, Katarzyna A. Piróg, Ian M. Clark, Matt J. Barter, Gavin J. Clowry, Fiona E. N. LeBeau, David A. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene t
Externí odkaz:
https://doaj.org/article/b74a1a1210eb465eb49f8ba80fb52c10
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1496 (2023)
The intracellular retention of mutant cartilage matrix proteins and pathological endoplasmic reticulum (ER) stress disrupts ossification and has been identified as a shared disease mechanism in a range of skeletal dysplasias including short limbed-dw
Externí odkaz:
https://doaj.org/article/d301e0e2774f45558f8f57501113d659
Autor:
Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Background Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is
Externí odkaz:
https://doaj.org/article/a4f7bbd62ff44cc7942e5f91d11de813
Autor:
Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1414-1425 (2013)
SUMMARY Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival. Delineating the relative contri
Externí odkaz:
https://doaj.org/article/3ea52079ed074c5f94274bc43ec6b790
Autor:
Peter A. Bell, Raimund Wagener, Frank Zaucke, Manuel Koch, Julian Selley, Stacey Warwood, David Knight, Raymond P. Boot-Handford, David J. Thornton, Michael D. Briggs
Publikováno v:
Biology Open, Vol 2, Iss 8, Pp 802-811 (2013)
Summary Pseudoachondroplasia and multiple epiphyseal dysplasia are genetic skeletal diseases resulting from mutations in cartilage structural proteins. Electron microscopy and immunohistochemistry previously showed that the appearance of the cartilag
Externí odkaz:
https://doaj.org/article/7dede92b37ab4afaad40a786ac0bbdf0
Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. CRELD2 is an ER-stress regulated gene that has been implicated in the pathogenesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6775aaa755ccef3b6080ccb9a8f8ab08
https://doi.org/10.21203/rs.3.rs-1435321/v1
https://doi.org/10.21203/rs.3.rs-1435321/v1
Publikováno v:
Developmental Dynamics. 250:345-359
For the vast majority of the 6000 known rare disease the pathogenic mechanisms are poorly defined and there is little treatment, leading to poor quality of life and high healthcare costs. Genetic skeletal diseases (skeletal dysplasias) are archetypal
Autor:
Michael D. Briggs, Robert M. Jackson, Dimitra Tsompani, Yao Hao, Katarzyna A. Piróg, Tamara Modebadze, Jamie Soul, Gavin J. Clowry, David Young, Fiona E. N. LeBeau, Sarah Charlton, Colin G. Miles, Ian M. Clark, Dan J. Hayman, Kathleen Cheung, Hua Lin, Matt J. Barter
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418215007155d56e894db76e03d3933
https://ueaeprints.uea.ac.uk/id/eprint/80121/
https://ueaeprints.uea.ac.uk/id/eprint/80121/
Autor:
Sarah M. Edwards, Michael D. Briggs, Claire L. Hartley, Raymond P. Boot‐Handford, Dimitra Tsompani, Anna Teti, Katarzyna A. Piróg, Mattia Capulli, Robert M. Jackson, Ella P. Dennis, David Young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67ed5d1a102a484308de6358d3f8e380
https://doi.org/10.1002/jbmr.4010/v2/response1
https://doi.org/10.1002/jbmr.4010/v2/response1