Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael D. Boisclair"'
Autor:
Steven P. Seitz, Sarah Cox, Pieter F. W. Stouten, Michael D. Boisclair, Stephen L. Brenner, Jay A. Markwalder, Karen A. Rossi, Leonardo Brizuela, Chong-Hwan Chang
Publikováno v:
Journal of Computer-Aided Molecular Design. 19:111-122
Cyclin-dependent kinases (CDKs) play a key role in regulating the cell cycle. The cyclins, their activating agents, and endogenous CDK inhibitors are frequently mutated in human cancers, making CDKs interesting targets for cancer chemotherapy. Our ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3c76fd64d0c81bfd1aa15bb3976390
https://doi.org/10.1007/s10822-005-1778-x
https://doi.org/10.1007/s10822-005-1778-x
Autor:
Jie Liu, John F. Boylan, Chong-Hwan Chang, Thais M. Sielecki, Haiying Chen, Robert H. Grafstrom, Angela Smallwood, Catherine R. Burton, Michael D. Boisclair, Steven P. Seitz, Tricia L. Johnson, Sarah Cox, George L. Trainor, Pamela A. Benfield, Jodi K. Muckelbauer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1157-1160
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ad1b9deac14818da4c2f1d31294004
https://doi.org/10.1016/s0960-894x(01)00185-8
https://doi.org/10.1016/s0960-894x(01)00185-8
Autor:
Peter J. Worland, Christopher McClure, Muzammil M. Mansuri, Krishna K. Murthi, Marja Dubay, Leonardo Brizuela, Kollol Pal, Michael D. Boisclair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1037-1041
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d48b3f68b93167c6935848cccdc3b2b
https://doi.org/10.1016/s0960-894x(00)00156-6
https://doi.org/10.1016/s0960-894x(00)00156-6
Autor:
David Epstein, Gustave Bergnes, Carla L. Gilliam, Katharine V. Blake, Kollol Pal, Michael D. Boisclair, Jill Blanchard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2849-2854
The four-component Ugi reaction was utilized to prepare a library of dipeptidic compounds in order to explore the binding requirements of the key cell cycle phosphatase, Cdc25. Several phosphate surrogates were incorporated into the Ugi product to mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f976a223ba03f4b283d258b32f718d2
https://doi.org/10.1016/s0960-894x(99)00497-7
https://doi.org/10.1016/s0960-894x(99)00497-7
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2015-2020
Analogs of sulfircin (1) were synthesized and tested for inhibitory activity against a panel of phosphatases. We attempted to optimize the potency and selectivity of sulfircin for Cdc25A by modifying three structural areas of the molecule. An anionic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f31a02da8c472a0be4c14941896583e
https://doi.org/10.1016/s0960-894x(97)00357-0
https://doi.org/10.1016/s0960-894x(97)00357-0
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a8608e8d9a7a5ea6957bf8333cd532e
https://doi.org/10.1002/chin.199749204
https://doi.org/10.1002/chin.199749204
Autor:
David Epstein, Carla L. Gilliam, Katharine V. Blake, Kollol Pal, Michael D. Boisclair, Jill Blanchard, Gustave Bergnes
Publikováno v:
ChemInform. 31
The four-component Ugi reaction was utilized to prepare a library of dipeptidic compounds in order to explore the binding requirements of the key cell cycle phosphatase, Cdc25. Several phosphate surrogates were incorporated into the Ugi product to mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b11062a675c5265713654948ec92795
https://doi.org/10.1002/chin.200005282
https://doi.org/10.1002/chin.200005282
Autor:
Leonardo Brizuela, Krishna K. Murthi, Peter J. Worland, Marja Dubay, Kollol Pal, Michael D. Boisclair, Christopher McClure, Muzammil M. Mansuri
Publikováno v:
ChemInform. 31
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::968ca1c68e954bd8970f953d6ee03704
https://doi.org/10.1002/chin.200035118
https://doi.org/10.1002/chin.200035118
Autor:
Sarah Cox, Michael D. Boisclair, Charity L. Dean, Philip M. Czerniak, Pieter F. W. Stouten, David A. Nugiel, Steven P. Seitz, Chong-Hwan Chang, Catherine R. Burton, Marc R. Arnone, Lisa M. Sisk, Robert F. Kaltenbach, Barbara A. Harrison, Pamela A. Benfield, Robert H. Grafstrom, Jay A. Markwalder, Susan R. Sherk, Karen A. Rossi, Deborah Doleniak, Peter Worland, George L. Trainor
Publikováno v:
Journal of medicinal chemistry. 47(24)
Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones was identified that inhibit the cyclin-dependent kinase (CDK) 4/cyclin D1 complex-mediated phosphorylation of a protein substrate with IC(50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c1e6f6796b80141bb11b65244f5b60
https://pubmed.ncbi.nlm.nih.gov/15537345
https://pubmed.ncbi.nlm.nih.gov/15537345
Autor:
Jie Liu, Robert H. Grafstrom, George L. Trainor, Kimberly Harrison, Diane M. Sharp, Jay A. Markwalder, David J. Carini, Yuki Nakano, Emeka Akamike, Pamela A. Benfield, Sarah Cox, John F. Boylan, Robert F. Kaltenbach, Catherine R. Burton, Thais M. Sielecki, Michael D. Boisclair, Steven P. Seitz, Barbara A. Harrison, Leonardo Brizuela
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(16)
A new structural type of kinase inhibitor, containing a benzocarbazole nucleus, has been identified. Members of the series are selective for inhibition of the cyclin dependent kinase family of enzymes. Although the cdks are highly homologous, represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4dd1b0d19daec08bd85ca37108b9d0
https://pubmed.ncbi.nlm.nih.gov/11514172
https://pubmed.ncbi.nlm.nih.gov/11514172