Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael D Sjaastad"'
Autor:
Cynthia L Adams, Michael D Sjaastad
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 12:877-887
Automated high-content screening and analysis (HCS/HCA) technology solutions have become indispensable in expediting the pace of drug discovery. Because of the complexity involved in designing, building, and validating HCS/HCA platforms, it is import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324f5d3eca8268213a63240d0a85690a
https://doi.org/10.2174/138620709789383240
https://doi.org/10.2174/138620709789383240
Autor:
Christopher J. Gilpin, Christoph Wülfing, Kenneth S. Chen, Nadia Parvaze, Mark M. Davis, Michael D. Sjaastad, Kentner L. Singleton, Kavyya R. Dama, Paula Jennings, Bozidar Purtic
Publikováno v:
The Journal of Immunology. 177:4402-4413
T cell activation is driven by the TCR and complemented by costimulation. We have studied the dynamics of ligand-engagement of the costimulatory receptor CD2 in T cell/APC couples. Thousands of ligand-engaged CD2 molecules were included in a large T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28fdcb051fccfbe531694fe6e4a0897
https://doi.org/10.4049/jimmunol.177.7.4402
https://doi.org/10.4049/jimmunol.177.7.4402
Autor:
Christoph Wülfing, Michael D. Sjaastad, Nigel J. Burroughs, Irina Tskvitaria-Fuller, John D. Schatzle, Jennifer Klem
Publikováno v:
Immunological Reviews. 189:64-83
Cellular interaction is vital to the activation of most lymphocytes. At the interface between the lymphocyte and the cell that activates it, multiple receptor/ligand pairs accumulate in distinct patterns. This accumulation is intriguing, as it is lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b8dee0391b697a78286e86c7f921d0
https://doi.org/10.1034/j.1600-065x.2002.18907.x
https://doi.org/10.1034/j.1600-065x.2002.18907.x
Autor:
Christoph Wülfing, Harden M. McConnell, Mark M. Davis, Michael D. Sjaastad, Joshua D. Rabinowitz, Craig Beeson
Publikováno v:
The Journal of Experimental Medicine
We have characterized the calcium response of a peptide–major histocompatibility complex (MHC)-specific CD4+ T lymphocyte line at the single cell level using a variety of ligands, alone and in combination. We are able to distinguish four general pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1002d8b2b9d6a444e9b61799a48b8043
https://doi.org/10.1084/jem.185.10.1815
https://doi.org/10.1084/jem.185.10.1815
Publikováno v:
Molecular Biology of the Cell. 7:1025-1041
Peptides containing Arg-Gly-Asp (RGD) immobilized on beads bind to integrins and trigger biphasic, transient increases in intracellular free Ca2+ ([Ca2+]i) in Madin-Darby canine kidney epithelial cells. The [Ca2+]i increase participates in feedback r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7036e19eb88e24ca8f3ef119a066bb3
https://doi.org/10.1091/mbc.7.7.1025
https://doi.org/10.1091/mbc.7.7.1025
Publikováno v:
Methods in enzymology. 414
Finding natural and/or synthetic ligands that activate orphan G protein-coupled receptors (oGPCRs) is a major focus in current drug discovery efforts. Transfluor is a cell-based GPCR screening platform that utilizes an arrestin-green fluorescent prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c2e9b9cc15ccbad09525c6c9937ed6e
https://pubmed.ncbi.nlm.nih.gov/17110186
https://pubmed.ncbi.nlm.nih.gov/17110186
Publikováno v:
Methods in enzymology. 414
G protein-coupled receptors (GPCRs) have proven to be one of the most successful target classes for drug discovery. Accordingly, many assays are available to screen GPCRs, including radioactive-binding assays, second messenger signaling assays, and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::016b3ea6990bc3059354e8bcf7d69a17
https://pubmed.ncbi.nlm.nih.gov/17110187
https://pubmed.ncbi.nlm.nih.gov/17110187
Finding natural and/or synthetic ligands that activate orphan G protein-coupled receptors (oGPCRs) is a major focus in current drug discovery efforts. Transfluor is a cell-based GPCR screening platform that utilizes an arrestin-green fluorescent prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a2f5839875ed46dfa6b516ade3eaf2
https://doi.org/10.1016/s0076-6879(06)14004-5
https://doi.org/10.1016/s0076-6879(06)14004-5
G protein‐coupled receptors (GPCRs) have proven to be one of the most successful target classes for drug discovery. Accordingly, many assays are available to screen GPCRs, including radioactive‐binding assays, second messenger signaling assays, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9097637e2c7c87e267f4364ac7b7179
https://doi.org/10.1016/s0076-6879(06)14005-7
https://doi.org/10.1016/s0076-6879(06)14005-7
Autor:
Christoph, Wülfing, Irina, Tskvitaria-Fuller, Nigel, Burroughs, Michael D, Sjaastad, Jennifer, Klem, John D, Schatzle
Publikováno v:
Immunological reviews. 189
Cellular interaction is vital to the activation of most lymphocytes. At the interface between the lymphocyte and the cell that activates it, multiple receptor/ligand pairs accumulate in distinct patterns. This accumulation is intriguing, as it is lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9f90e2f17d4e04030a035bd233b3e20
https://pubmed.ncbi.nlm.nih.gov/12445266
https://pubmed.ncbi.nlm.nih.gov/12445266