Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Michael D Reily"'
Autor:
Amanda M Lewis, William D Croughan, Nelly Aranibar, Alison G Lee, Bethanne Warrack, Nicholas R Abu-Absi, Rutva Patel, Barry Drew, Michael C Borys, Michael D Reily, Zheng Jian Li
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157111 (2016)
A Chinese hamster ovary (CHO) bioprocess, where the product is a sialylated Fc-fusion protein, was operated at pilot and manufacturing scale and significant variation of sialylation level was observed. In order to more tightly control glycosylation p
Externí odkaz:
https://doaj.org/article/f7824c128d3c42edbdc25a3852fe8552
Publikováno v:
Analytical Chemistry. 92:14501-14508
Extracellular adenosine, produced through the activity of ecto-5′-nucleotidase CD73, elicits potent immunosuppressive effects, and its upregulation in tumor cells as well as in stromal and immune c...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8e9ad9911cddfd4906807a70ea5ccb
https://doi.org/10.1021/acs.analchem.0c02630
https://doi.org/10.1021/acs.analchem.0c02630
Autor:
Erik Langsdorf, Yueming Qian, Michael D. Reily, Jianlin Xu, Nan-xin Qian, Nelly Aranibar, Zheng Jian Li, Christopher Oliveira, Qin He, Susan Egan, Michael C. Borys, Jun Tian, Bethanne M. Warrack
Publikováno v:
Engineering in Life Sciences
Increasing cell culture productivity of recombinant proteins via process improvements is the primary focus for research groups within biologics manufacturing. Any recommendations to improve a manufacturing process obviously must be effective, but als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0197726f18c706e85674a324c515ae53
http://europepmc.org/articles/PMC7447880
http://europepmc.org/articles/PMC7447880
Publikováno v:
Analytical chemistry. 92(21)
Extracellular adenosine, produced through the activity of ecto-5'-nucleotidase CD73, elicits potent immunosuppressive effects, and its upregulation in tumor cells as well as in stromal and immune cell subsets within the tumor microenvironment is hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9bd912fe180c290caa81a6924f915778
https://pubmed.ncbi.nlm.nih.gov/32985862
https://pubmed.ncbi.nlm.nih.gov/32985862
Autor:
Ashli Polanco, Seo-Young Park, Zheng Jian Li, Kevin S. McFarland, Jia Zhao, Jianlin Xu, Michael D. Reily, Andrew Yongky, Caitlin Morris, Zhuangrong Huang, Seongkyu Yoon, Bethanne M. Warrack, Michael C. Borys
Publikováno v:
Bioresources and Bioprocessing, Vol 7, Iss 1, Pp 1-13 (2020)
Recent advances in metabolite quantification and identification have enabled new research into the detection and control of titer inhibitors and promoters. This paper presents a bigdata analytics study to identify both inhibitors and promoters using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e7de6b5a1049536e2f248dff3488cf
https://doi.org/10.1186/s40643-020-00318-6
https://doi.org/10.1186/s40643-020-00318-6
Publikováno v:
Journal of Applied Bioanalysis, Vol 4, Iss 1, Pp 26-31 (2018)
In LC-MS bioanalysis, samples and analytes are quantified against calibration solutions and curves which are derived via serial dilution from stock solutions that are prepared from dry reference standards. The analytical errors associated with the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eef1db041feb2b034cef232706ebaaa
https://doaj.org/article/111ce73735e347219517bd5d6dae8b38
https://doaj.org/article/111ce73735e347219517bd5d6dae8b38
Autor:
Yurong Lai, Regina V. Oliveira, W. Griffith Humphreys, Yueping Zhang, David M. Nelson, Jinping Gan, Petia Shipkova, Michael D. Reily, Xiaomei Gu, Ching Su, Hong Shen, Weiqi Chen, Colleen A. McNaney, Punit Marathe
Publikováno v:
Drug Metabolism and Disposition. 46:178-188
Perturbation of organic anion transporter (OAT) 1- and OAT3-mediated transport can alter the exposure, efficacy, and safety of drugs. Although there have been reports of the endogenous biomarkers for OAT1/3, none of these have all of the characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddd7f42e11c693cf5ccc8e15104b64a
https://doi.org/10.1124/dmd.117.077586
https://doi.org/10.1124/dmd.117.077586
Autor:
Dean Billheimer, Elmira Torabzadeh, Zhengqiang Lu, Nelly Aranibar, April D. Lake, Michael D. Reily, Nathan J. Cherrington, Lois D. Lehman-McKeeman, Hui Li, Donald G. Robertson, Jian Hua Han, Petr Novák, Anika L. Dzierlenga, Petia Shipkova
Publikováno v:
Obesity. 25:1069-1076
Objective Characteristic pathological changes define the progression of steatosis to nonalcoholic steatohepatitis (NASH) and are correlated to metabolic pathways. A common rodent model of NASH is the methionine and choline deficient (MCD) diet. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62da47d792b0e6238471a196a84ca2f7
https://doi.org/10.1002/oby.21855
https://doi.org/10.1002/oby.21855
Autor:
Punit Marathe, Lisa Zhang, Janet Caceres-Cortes, Christine Huang, Purnima Khandelwal, Anjaneya Chimalakonda, Michael D. Reily
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 171
Conjugation of macromolecular drugs to polyethylene glycol (PEG) improves their therapeutic potential by reducing their rate of degradation, thereby extending the drugs half life. As a substantial component of the drug, it is necessary to measure the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315daf94e005713dcf66dce9209b3a1c
https://pubmed.ncbi.nlm.nih.gov/30959317
https://pubmed.ncbi.nlm.nih.gov/30959317
Autor:
Joshua C. Curtin, Stephen Hillerman, Rukiye Eraslan, Jinqi Liu, Dan You, Bifang Li-Wang, Taeg Kim, Anwar Murtaza, John T. Hunt, David M. Nelson, Jesse Swanson, Jordan Blum, Mark Fereshteh, Michael D. Reily, Petia Shipkova, Jenny Xie, Bethanne M. Warrack, Luisa Salter-Cid, Colleen A. McNaney, Simone Oppenheimer, Miguel Sanjuan, Ching-Ping Ho
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212670 (2019)
PLoS ONE
PLoS ONE
Immunotherapy has fundamentally changed the landscape of cancer treatment. Despite the encouraging results with the checkpoint modulators, response rates vary widely across tumor types, with a majority of patients exhibiting either primary resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccd2972f9b8159008a872a7d2c5b24b
https://doaj.org/article/7604dc75ad594b68a709196c2f123df0
https://doaj.org/article/7604dc75ad594b68a709196c2f123df0