Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Michael D Lewis"'
Autor:
Harry Langston, Amanda Fortes Francisco, Ciaran Doidge, Chrissy H Roberts, Archie A Khan, Shiromani Jayawardhana, Martin C Taylor, John M Kelly, Michael D Lewis
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 6, p e0012278 (2024)
Chagas disease is a zoonosis caused by the protozoan parasite Trypanosoma cruzi. Clinical outcomes range from long-term asymptomatic carriage to cardiac, digestive, neurological and composite presentations that can be fatal in both acute and chronic
Externí odkaz:
https://doaj.org/article/6807b2b04f02489989bb08c3986bec76
Autor:
Shiromani Jayawardhana, Alexander I Ward, Amanda F Francisco, Michael D Lewis, Martin C Taylor, John M Kelly, Francisco Olmo
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011627 (2023)
Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the causative agent of Chagas disease. However, for reasons that are unknown, treatment failures are common. When we examined parasites that survived benznidazole tr
Externí odkaz:
https://doaj.org/article/a0e4de6f8db44ede83db51373f51d471
Autor:
Gabriel Machado Matos, Michael D Lewis, Carlos Talavera-López, Matthew Yeo, Edmundo C Grisard, Louisa A Messenger, Michael A Miles, Björn Andersson
Publikováno v:
eLife, Vol 11 (2022)
Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic exchange. However, the presence and epidemiological relevance of genetic exchange in Trypanosoma cruzi, the agent of Chagas disease, has been controversial and debated
Externí odkaz:
https://doaj.org/article/54b78a580153477c8d8183ed3a7e9329
Autor:
Archie A Khan, Harry C Langston, Fernanda C Costa, Francisco Olmo, Martin C Taylor, Conor J McCann, John M Kelly, Michael D Lewis
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009864 (2021)
Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. The mechanism of pathogenesis is poorly understood and the lack of a robust, predictive animal model has held back research. We screened a series of mouse
Externí odkaz:
https://doaj.org/article/ce5e49f6159a4b51957df35aa743d66a
Autor:
Philipp Schwabl, Jalil Maiguashca Sánchez, Jaime A Costales, Sofía Ocaña-Mayorga, Maikell Segovia, Hernán J Carrasco, Carolina Hernández, Juan David Ramírez, Michael D Lewis, Mario J Grijalva, Martin S Llewellyn
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009170 (2020)
Analysis of genetic polymorphism is a powerful tool for epidemiological surveillance and research. Powerful inference from pathogen genetic variation, however, is often restrained by limited access to representative target DNA, especially in the stud
Externí odkaz:
https://doaj.org/article/8c626f90dac74c6c836e77ad28ead76e
Autor:
Gurdip Singh Mann, Amanda F Francisco, Shiromani Jayawardhana, Martin C Taylor, Michael D Lewis, Francisco Olmo, Elisangela Oliveira de Freitas, Fabiana M S Leoratti, Cesar López-Camacho, Arturo Reyes-Sandoval, John M Kelly
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0007717 (2020)
BACKGROUND:The long term and complex nature of Chagas disease in humans has restricted studies on vaccine feasibility. Animal models also have limitations due to technical difficulties in monitoring the extremely low parasite burden that is character
Externí odkaz:
https://doaj.org/article/a863b7d3bb75444bb1786fd421bc179f
Autor:
Michael D Lewis, Andrea Paun, Audrey Romano, Harry Langston, Charlotte A Langner, Ian N Moore, Kevin W Bock, Amanda Fortes Francisco, Jason M Brenchley, David L Sacks
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008456 (2020)
Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment sequelae, sp
Externí odkaz:
https://doaj.org/article/af5cfafb500f43f2863c96529f116712
Autor:
Martin C Taylor, Alexander Ward, Francisco Olmo, Shiromani Jayawardhana, Amanda F Francisco, Michael D Lewis, John M Kelly
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008007 (2020)
Investigations into intracellular replication and differentiation of Trypanosoma cruzi within the mammalian host have been restricted by limitations in our ability to detect parasitized cells throughout the course of infection. We have overcome this
Externí odkaz:
https://doaj.org/article/89ad7042100140bf94f5fcf01df57ac0
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006612 (2018)
Chagas' disease is responsible for significant mortality and morbidity in Latin America. Current treatments display variable efficacy and have adverse side effects, hence more effective, better tolerated drugs are needed. However, recent efforts have
Externí odkaz:
https://doaj.org/article/288def2732bd4cd0ab8accddd72b0e04
Autor:
Fernanda Cristina Costa, Amanda Fortes Francisco, Shiromani Jayawardhana, Simone Guedes Calderano, Michael D Lewis, Francisco Olmo, Tom Beneke, Eva Gluenz, Jack Sunter, Samuel Dean, John Morrison Kelly, Martin Craig Taylor
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006388 (2018)
BackgroundInfection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Latin America. There is no vaccine and the only drugs have severe side effects. Efforts to generate new therapies are hampered by limitations i
Externí odkaz:
https://doaj.org/article/a2fbb09216b04cdfb28b047579497d03