Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Michael D Keller"'
Autor:
Michael D. Keller, Patrick J. Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C. Dvorak, Michael R. Verneris, Donald B. Kohn, Sung-Yun Pai, Blachy J. Dávila Saldaña, Benjamin Hanisch, Troy C. Quigg, Roberta H. Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A. Jensen-Wachspress, Christopher A. Lazarski, Gelina Sani, John M. Idso, Haili Lang, Pamela Chansky, Chase D. McCann, Jay Tanna, Allistair A. Abraham, Jennifer L. Webb, Abeer Shibli, Amy K. Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J. Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N. De Oliveira, Mark T. Vander Lugt, Christen L. Ebens, Victor M. Aquino, Jeffrey J. Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T. Zambidis, Elizabeth Gourdine, Catherine M. Bollard, Michael A. Pulsipher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter stud
Externí odkaz:
https://doaj.org/article/fcdca2f7424c452f994b7e545a14509b
Autor:
Michael D. Keller, Stefan A. Schattgen, Shanmuganathan Chandrakasan, E. Kaitlynn Allen, Mariah A. Jensen-Wachspress, Christopher A. Lazarski, Muna Qayed, Haili Lang, Patrick J. Hanley, Jay Tanna, Sung-Yun Pai, Suhag Parikh, Seth I. Berger, Stephen Gottschalk, Michael A. Pulsipher, Paul G. Thomas, Catherine M. Bollard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Virus-specific T cells (VST) from partially-HLA matched donors have been effective for treatment of refractory viral infections in immunocompromised patients in prior studies with a good safety profile, but rare adverse events have been desc
Externí odkaz:
https://doaj.org/article/2d98f25b1b53444d849e04310e6b7692
Autor:
Vivien X. Xie, Wilson File, Christina Wiedl, Brant R. Ward, Blachy Dávila Saldaña, Michael D. Keller, Alexandra B. Kornbluh
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 19, Iss 1, Pp 1-7 (2023)
Abstract Background Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency caused by mutations in the WAS gene that leads to increased susceptibility to infections, thrombocytopenia, eczema, malignancies, and autoimmunity. Central ner
Externí odkaz:
https://doaj.org/article/a3a9d0ed32234d73a7fb321d7e546829
Autor:
Breanna J. Beers, Morgan N. Similuk, Rajarshi Ghosh, Bryce A. Seifert, Leila Jamal, Michael Kamen, Michael R. Setzer, Colleen Jodarski, Rylee Duncan, Devin Hunt, Madison Mixer, Wenjia Cao, Weimin Bi, Daniel Veltri, Eric Karlins, Lingwen Zhang, Zhiwen Li, Andrew J. Oler, Kathleen Jevtich, Yunting Yu, Haley Hullfish, Bibiana Bielekova, Pamela Frischmeyer-Guerrerio, An Dang Do, Laryssa A. Huryn, Kenneth N. Olivier, Helen C. Su, Jonathan J. Lyons, Christa S. Zerbe, V. Koneti Rao, Michael D. Keller, Alexandra F. Freeman, Steven M. Holland, Luis M. Franco, Magdalena A. Walkiewicz, Jia Yan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PurposeThough copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine the diagnostic contribution of CNVs using
Externí odkaz:
https://doaj.org/article/5a9a5d2c1d2843bb9d22ca82e9ec744f
Autor:
Jessica Durkee-Shock, Christopher A. Lazarski, Mariah A. Jensen-Wachspress, Anqing Zhang, Aran Son, Vaishnavi V. Kankate, Naomi E. Field, Kathleen Webber, Haili Lang, Susan R. Conway, Patrick J. Hanley, Catherine M. Bollard, Michael D. Keller, Daniella M. Schwartz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 439-447 (2022)
Adoptive T cell immunotherapy has been used to restore immunity against multiple viral targets in immunocompromised patients after bone-marrow transplantation and has been proposed as a strategy for preventing coronavirus 2019 (COVID-19) in this popu
Externí odkaz:
https://doaj.org/article/0c6adced537a4c309d8a4d4099cc8bb1
Autor:
Maria Chitty-Lopez, Carla Duff, Gretchen Vaughn, Jessica Trotter, Hector Monforte, David Lindsay, Elie Haddad, Michael D. Keller, Benjamin R. Oshrine, Jennifer W. Leiding
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Congenital athymia can present with severe T cell lymphopenia (TCL) in the newborn period, which can be detected by decreased T cell receptor excision circles (TRECs) on newborn screening (NBS). The most common thymic stromal defect causing selective
Externí odkaz:
https://doaj.org/article/b96224647da54f889487a98d2b9c6dd8
Autor:
Susan R. Conway, Christopher A. Lazarski, Naomi E. Field, Mariah Jensen-Wachspress, Haili Lang, Vaishnavi Kankate, Jessica Durkee-Shock, Hannah Kinoshita, William Suslovic, Kathleen Webber, Karen Smith, Jeffrey I. Cohen, Peter D. Burbelo, Anqing Zhang, Stephen J. Teach, Trisha Ibeh, Meghan Delaney, Roberta L. DeBiasi, Michael D. Keller, Catherine M. Bollard
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
BackgroundDespite similar rates of infection, adults and children have markedly different morbidity and mortality related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Compared to adults, children have infrequent severe manifestati
Externí odkaz:
https://doaj.org/article/fbd4c07f800448ce90d6e037e4979a41
Autor:
Thomas J. Galletta, Adam Lane, Carolyn Lutzko, Thomas Leemhuis, Jose A. Cancelas, Ruby Khoury, YunZu M. Wang, Patrick J. Hanley, Michael D. Keller, Catherine M. Bollard, Stella M. Davies, Michael S. Grimley, Jeremy D. Rubinstein
Publikováno v:
Transplantation and Cellular Therapy. 29:305-310
Autor:
Allistair A. Abraham, Tami D. John, Michael D. Keller, C. Russell N. Cruz, Baheyeldin Salem, Lauren Roesch, Hao Liu, Fahmida Hoq, Bambi J. Grilley, Adrian P. Gee, Hema Dave, David A. Jacobsohn, Robert A. Krance, Elizabeth. J. Shpall, Caridad A. Martinez, Patrick J. Hanley, Catherine M. Bollard
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2057-2068 (2019)
Abstract: Adoptive transfer of virus-specific T cells (VSTs) has been shown to be safe and effective in stem cell transplant recipients. However, the lack of virus-experienced T cells in donor cord blood (CB) has prevented the development of ex vivo
Externí odkaz:
https://doaj.org/article/c8185b6b4cdf45c295fb6e5a5bd795c2
Publikováno v:
Seminars in Hematology. 60:10-19