Výsledky vyhledávání - "Michael D Hogarty"

Akademický článek

Serum-Based Quantification of MYCN Gene Amplification in Young Patients with Neuroblastoma: Potential Utility as a Surrogate Biomarker for Neuroblastoma.

Autor: Shigeki Yagyu, Tomoko Iehara, Shiro Tanaka, Takahiro Gotoh, Akiko Misawa-Furihata, Tohru Sugimoto, Wendy B London, Michael D Hogarty, Satoshi Teramukai, Akira Nakagawara, Eiso Hiyama, John M Maris, Hajime Hosoi

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0161039 (2016)

We previously developed a method for determining MYCN gene amplification status using cell-free DNA fragments released from cancer cells into the blood of patients with neuroblastoma (NB). Here, we analyzed the relationship between MYCN amplification

Externí odkaz: https://doaj.org/article/623bd94eed5241259ab578803041b063

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Akademický článek

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

Autor: Laura Dawn Gamble, Michael D Hogarty, Xuenyuan eLiu, David S Ziegler, Glenn M Marshall, Murray D Norris, Michelle eHaber

Publikováno v: Frontiers in Oncology, Vol 2 (2012)

Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that upregulation of polyamine pro-synthetic enzymes and downregulation of

Externí odkaz: https://doaj.org/article/de2d901897dc4c3d92f85300445c3900

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Akademický článek

Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma

Autor: Karolina Borankova, Maria Krchniakova, Lionel Y. W. Leck, Adela Kubistova, Jakub Neradil, Patric J. Jansson, Michael D. Hogarty, Jan Skoda

Publikováno v: Cell Death and Disease, Vol 14, Iss 11, Pp 1-17 (2023)

Abstract Mitochondria are central for cancer responses to therapy-induced stress signals. Refractory tumors often show attenuated sensitivity to apoptotic signaling, yet clinically relevant molecular actors to target mitochondria-mediated resistance

Externí odkaz: https://doaj.org/article/41eadf257f734648918b7150a9589f88

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Akademický článek

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

Autor: Sofia Zanotti, Suzanne Vanhauwaert, Christophe Van Neste, Volodimir Olexiouk, Jolien Van Laere, Marlies Verschuuren, Joni Van der Meulen, Liselot M. Mus, Kaat Durinck, Laurentijn Tilleman, Dieter Deforce, Filip Van Nieuwerburgh, Michael D. Hogarty, Bieke Decaesteker, Winnok H. De Vos, Frank Speleman

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract MYCN is an oncogenic driver in neural crest-derived neuroblastoma and medulloblastoma. To better understand the early effects of MYCN activation in a neural-crest lineage context, we profiled the transcriptome of immortalized human retina pi

Externí odkaz: https://doaj.org/article/867372e4c7ba46fb8fbf180861fa84ee

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Akademický článek

Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma

Autor: Babak Moghimi, Sakunthala Muthugounder, Samy Jambon, Rachelle Tibbetts, Long Hung, Hamid Bassiri, Michael D. Hogarty, David M. Barrett, Hiroyuki Shimada, Shahab Asgharzadeh

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Antibodies targeting a tumor antigen, GD2, show some efficacy for neuroblastoma but induce severe neuropathic pain and peripheral neuropathy. Here the authors design a gated chimeric antigen receptor (CAR), using GD2 as the gate and another tumor ant

Externí odkaz: https://doaj.org/article/92c07d10ceed4a499ccaa1bcf1c46793

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Akademický článek

Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Genomic analysis of neuroblastoma has revealed important disease etiology. In this study, the authors assembled whole genome, exome and transcriptome data from over 700 neuroblastomas and identified molecular signatures correlated with age, and rare,

Externí odkaz: https://doaj.org/article/6d1ddb168abf4a2ea4dc3f42ec5b32a2

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Akademický článek

MYCN amplification and ATRX mutations are incompatible in neuroblastoma

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.

Externí odkaz: https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd61

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Survival of Patients With Neuroblastoma After Assignment to Reduced Therapy Because of the 12- to 18-Month Change in Age Cutoff in Children's Oncology Group Risk Stratification

Autor: Hannah G. Bender, Meredith S. Irwin, Michael D. Hogarty, Robert Castleberry, John M. Maris, Pei-Chi Kao, Fan F. Zhang, Arlene Naranjo, Susan L. Cohn, Wendy B. London

Publikováno v: Journal of Clinical Oncology.

PURPOSE In 2006, Children's Oncology Group (COG) reclassified subgroups of toddlers diagnosed with neuroblastoma from high-risk to intermediate-risk, when the age cutoff for high-risk assignment was raised from 365 days (12 months) to 547 days (18 mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80ff5e69da438f9ef41d0f69f9c2aa7d
https://doi.org/10.1200/jco.22.01946

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