Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Michael D Henry"'
Autor:
Courtney Yong, Devon L Moose, Nadine Bannick, Wade R Gutierrez, Marion Vanneste, Robert Svensson, Patrick Breheny, James A Brown, Rebecca D Dodd, Michael B Cohen, Michael D Henry
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232807 (2020)
Here we have improved an existing mouse model of prostate cancer based on prostate-specific deletion of Pten and Trp53 by incorporating a Cre-activatable luciferase reporter. By coupling the deletion of those genes to the activation of a luciferase r
Externí odkaz:
https://doaj.org/article/ce7d1f3ddce84cf390873022563396c7
Autor:
Morgan C. Finnerty, Franklin E. Leach, Yousef Zakharia, Kenneth G. Nepple, Michael G. Bartlett, Michael D. Henry, Brian S. Cummings
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Docetaxel is commonly used for treatment of castration-resistant prostate cancer. Unfortunately, many prostate cancer patients develop resistance to docetaxel. Clinical markers less invasive than biopsies, such as blood samples, would be ide
Externí odkaz:
https://doaj.org/article/e6ae2ad0ea39429b927acce33bffe893
Autor:
Marisa R Buchakjian, Nicole M Merritt, Devon L Moose, Adam J Dupuy, Munir R Tanas, Michael D Henry
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183469 (2017)
Genetic mouse models of soft tissue sarcoma provide critical insights into disease pathophysiology, which are oftentimes unable to be extracted from human tumor samples or xenograft models. In this study we describe a mouse model of soft tissue sarco
Externí odkaz:
https://doaj.org/article/110cec91e0cb46afa5b7de457cbbbd2d
Autor:
Mary E. Herndon, Mitchell Ayers, Katherine N. Gibson-Corley, Michael K. Wendt, Lori L. Wallrath, Michael D. Henry, Christopher S. Stipp
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/1e678e4757f2403b873c0fa0b35faf2b
Autor:
Trenton L Place, Jones T Nauseef, Maina K Peterson, Michael D Henry, James J Mezhir, Frederick E Domann
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83021 (2013)
Prolyl-4-hydroxylation by the intracellular prolyl-4-hydroxylase enzymes (PHD1-3) serves as a master regulator of environmental oxygen sensing. The activity of these enzymes is tightly tied to tumorigenesis, as they regulate cell metabolism and angio
Externí odkaz:
https://doaj.org/article/6aa167b777d14e0999afcc5dfdba1678
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50973 (2012)
During metastasis, cancer cells enter the circulation in order to gain access to distant tissues, but how this fluid microenvironment influences cancer cell biology is poorly understood. A longstanding view is that circulating cancer cells derived fr
Externí odkaz:
https://doaj.org/article/7e83707416dd4f94b058d4bd4de694ab
Autor:
Lyse A Norian, Timothy P Kresowik, Henry M Rosevear, Britnie R James, Timothy R Rosean, Andrew J Lightfoot, Tamara A Kucaba, Christopher Schwarz, Christine J Weydert, Michael D Henry, Thomas S Griffith
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31085 (2012)
Despite evidence that antitumor immunity can be protective against renal cell carcinoma (RCC), few patients respond objectively to immunotherapy and the disease is fatal once metastases develop. We asked to what extent combinatorial immunotherapy wit
Externí odkaz:
https://doaj.org/article/4fe1df20141b475bafe5b1f1f928699e
Autor:
Jianling Bi, Emily Witt, Megan K. McGovern, Arielle B. Cafi, Lauren L. Rosenstock, Anna B. Pearson, Timothy J. Brown, Thomas B. Karasic, Lucas C. Absler, Srija Machkanti, Hannah Boyce, David Gallo, Sarah L. Becker, Keiko Ishida, Joshua Jenkins, Alison Hayward, Alexandra Scheiflinger, Kellie L. Bodeker, Ritesh Kumar, Scott K. Shaw, Salma K. Jabbour, Vitor A. Lira, Michael D. Henry, Michael S. Tift, Leo E. Otterbein, Giovanni Traverso, James D. Byrne
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Modulation of autophagy, specifically its inhibition, stands to transform the capacity to effectively treat a broad range of cancers. However, the clinical efficacy of autophagy inhibitors has been inconsistent. To delineate clinical and epi
Externí odkaz:
https://doaj.org/article/f858b9587aa7486a8b205a415ae94226
Autor:
Marion Vanneste, Anita Venzke, Soumitra Guin, Andrew J. Fuller, Andrew J. Jezewski, Sarah R. Beattie, Damian J. Krysan, Marvin J. Meyers, Michael D. Henry
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAn attractive, yet unrealized, goal in cancer therapy is repurposing psychiatric drugs that can readily penetrate the blood-brain barrier for the treatment of primary brain tumors and brain metastases. Phenothiazines (PTZs) have demonstra
Externí odkaz:
https://doaj.org/article/4334b357eab940c8a068c9537ffc9a99
Autor:
Melissa A. Marchal, Devon L. Moose, Afshin Varzavand, Nicole E. Jordan, Destiney Taylor, Munir R. Tanas, James A. Brown, Michael D. Henry, Christopher S. Stipp
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAbl family kinases function as proto-oncogenes in various leukemias, and pro-tumor functions have been discovered for Abl kinases in many solid tumors as well. However, a growing body of evidence indicates that Abl kinases can function to
Externí odkaz:
https://doaj.org/article/3f74f3b22e7d4202910ff27fb642931d