Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael D, Winther"'
Autor:
Nicholas L. Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Raymond CS Seet, Wee Tiong Yeo, William Kristanto, Ping-Chong Bee, LM Poon, Patrick Marban, Tuck Seng Wu, Michael D. Winther, Liam R. Brunham, Richie Soong, Bee-Choo Tai, Boon-Cher Goh
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-10 (2018)
Abstract Background Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. Methods An open-label, non-inf
Externí odkaz:
https://doaj.org/article/087728fcda5943cda118924e863a9094
Autor:
Pramote Tragulpiankit, Noppadol Chanhom, Ly Le, Francis R. Capule, Tin Maung Hlaing, Dzul Azri Mohamed Noor, Asma A Apos Tiyah Abdul Hamid, Usa Chaikledkaew, Sukanya Wattanapokayakit, Wasun Chantratita, Lakkana Suwannoi, Shamsul Mohd Zain, Soranun Chantarangsu, Surakameth Mahasirimongkol, Kyaw Soe Htun, Jesus Shrestha, Rika Yuliwulandari, Saowalak Turongkaravee, Zen H. Lu, Supatat Chumnumwat, Bibek Bhandari, Chonlaphat Sukasem, Angkana Charoenyingwattana, Michael D. Winther, Jiraphun Jittikoon, Tong Thi Hang, Phonepadith Xangsayarath
Publikováno v:
Public Health Genomics. 22:132-139
Pharmacogenomics (PGx) is increasingly being recognized as a potential tool for improving the efficacy and safety of drug therapy. Therefore, several efforts have been undertaken globally to facilitate the implementation process of PGx into routine c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::309bad03973383728a0eb2034da7907b
https://doi.org/10.1159/000502916
https://doi.org/10.1159/000502916
Autor:
Michael D. Winther, Cynthia Sung, Sze Ling Chan, Alexandre Chan, Hong Yen Ng, Liam R. Brunham, Hwee Lin Wee
Publikováno v:
The Pharmacogenomics Journal. 19:401-410
Adverse drug reactions (ADRs) contribute to hospitalization but data on its economic burden is scant. Pre-emptive pharmacogenetic (PGx) testing can potentially reduce ADRs and its associated costs. The objectives of this study were to quantify the ec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bc6fede86523422a77de7d1df427ce
https://doi.org/10.1038/s41397-018-0053-1
https://doi.org/10.1038/s41397-018-0053-1
Autor:
Liam R. Brunham, Soo-Chin Lee, Nicholas Syn, James Yip, William Kristanto, Wee Tiong Yeo, Andrea Li Ann Wong, Raymond Cs Seet, Patrick Marban, Michael D. Winther, Richie Soong, Bee Choo Tai, Ping Chong Bee, Li Mei Poon, Boon Cher Goh, Tuck Seng Wu, Hock-Luen Teoh
Publikováno v:
BMC Medicine
BMC Medicine, Vol 16, Iss 1, Pp 1-10 (2018)
BMC Medicine, Vol 16, Iss 1, Pp 1-10 (2018)
Background: Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry, yet its utility in Asian patients remains unresolved. Methods: An open-label, non-inferiorit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17361e5419862df300da9def3011df45
https://doi.org/10.1186/s12916-018-1093-8
https://doi.org/10.1186/s12916-018-1093-8
Autor:
Liam R. Brunham, Sze Ling Chan, Hazel Xiaohui Ang, Boon Ooi Patrick Tan, Michael D. Winther, Levana L. Sani, Clarissa Bernice Quah
Publikováno v:
Pharmacogenomics. 18(9)
While early pharmacogenomic studies have primarily been carried out in Western populations, there has been a notable increase in the number of Asian studies over the past decade. We systematically reviewed all pharmacogenomic studies conducted in Asi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209b8b51c519dbf729ba39b7969e71f3
https://pubmed.ncbi.nlm.nih.gov/28594321
https://pubmed.ncbi.nlm.nih.gov/28594321
Autor:
Rostam Namdari, Jianmin Fu, Brian K. Hubbard, Kuldip Khakh, Suzie Ferreira, Michael D. Winther, Zaihui Zhang, Vandna Raina, Duanjie Hou, Natalie Dales, David G. McLaren, Leslie G. Ratkay, Pokrovskaia Natalia, Shaoyi Sun, Monica Mork
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:526-531
We discovered a series of novel and potent thiazolylpyridinone-based SCD1 inhibitors based on a 2-aminothiazole HTS hit by replacing the amide bond with a pyridinone moiety. Compound 19 demonstrated good potency against SCD1 in vitro and in vivo. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30298b86448d213fe671561704871195
https://doi.org/10.1016/j.bmcl.2013.12.035
https://doi.org/10.1016/j.bmcl.2013.12.035
Autor:
Shifeng Liu, Sultan Chowdhury, Michael D. Winther, Xing Cheng, Kuldip Khakh, Shaoyi Sun, Heinz W. Gschwend, Duanjie Hou, Nagasree Chakka, Zaihui Zhang, Leslie G. Ratkay, Serguei Sviridov, Jianmin Fu, David G. McLaren, Rajender Kamboj, Vishnumurthy Kodumuru
Publikováno v:
Journal of Medicinal Chemistry. 56:568-583
Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monounsaturated fatty acids from saturated fatty acids. Studies have demonstrated that rodents lacking a functional SCD1 gene have an improved metabolic profile, including reduced weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3733c3e49f50d75c915eee4c884641ec
https://doi.org/10.1021/jm301661h
https://doi.org/10.1021/jm301661h
Autor:
Alexandre Chan, Liam R. Brunham, Levana L. Sani, Xiaohui Ang, Michael D. Winther, Jianjun Liu, Sze Ling Chan, Hong Yen Ng
Publikováno v:
British journal of clinical pharmacology, vol 82, iss 6
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology
Aims Adverse drug reactions (ADRs) contribute to poorer patient outcomes and additional burden to the healthcare system. However, data on the true burden, relevant types and drugs causing ADRs are lacking. The aim of this study was to determine the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32f0307cba3f383c9f582274a7edcaf
https://escholarship.org/uc/item/7h42n79q
https://escholarship.org/uc/item/7h42n79q
Autor:
Shaoyi Sun, David G. McLaren, Elaine Chang, Qi Jia, Kuldip Khakh, Zaihui Zhang, Natalie Dales, Jianmin Fu, Sultan Chowdhury, Pokrovskaia Natalia, Rainbow Kwan, Michael D. Winther, Chris Radomski, Leslie G. Ratkay
Publikováno v:
Bioorganicmedicinal chemistry. 23(3)
Stearoyl-CoA desaturase-1 (SCD1) plays an important role in lipid metabolism. Inhibition of SCD1 activity represents a potential novel approach for the treatment of metabolic diseases such as obesity, type 2 diabetes and dyslipidemia, as well as skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b1157afec709c145687bb5d2826516
https://pubmed.ncbi.nlm.nih.gov/25555732
https://pubmed.ncbi.nlm.nih.gov/25555732
Publikováno v:
Journal of medicinal chemistry. 57(12)
This review provides an overview of stearoyl-coenzyme A desaturase-1 (SCD1) as a novel therapeutic target for metabolic disorders and other indications. Target validation is reviewed, and limitations due to incomplete knowledge of the relevant biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::884db65e76cf6fde8b38651a05dcdfd2
https://pubmed.ncbi.nlm.nih.gov/24295027
https://pubmed.ncbi.nlm.nih.gov/24295027