Zobrazeno 1 - 10
of 1 275
pro vyhledávání: '"Michael D, Taylor"'
Autor:
Kandarp Joshi, Menglang Yuan, Keisuke Katsushima, Olivier Saulnier, Animesh Ray, Ernest Amankwah, Stacie Stapleton, George Jallo, Michael D. Taylor, Charles G. Eberhart, Ranjan J. Perera
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Medulloblastoma, the most common malignant pediatric brain tumor, is classified into four main molecular subgroups, but group 3 and group 4 tumors are difficult to subclassify and have a poor prognosis. Rapid point-of-care diagnostic and pro
Externí odkaz:
https://doaj.org/article/326f988b197f4347bf4fff9b3108c6a0
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103260- (2024)
Summary: Cancer stem cells (CSCs) established from surgical biopsies closely mimic the human context and can be used to investigate disease mechanisms, genetic fitness, and therapeutic evaluation. Here, we present a protocol for the derivation of pri
Externí odkaz:
https://doaj.org/article/1bc5101bac0443238e48891b18b50ee4
Autor:
Benjamin Draper, Chantelle Bowers, Eleni Vassalou, Ailsa Greppi, John Anderson, Nabil Ahmed, Michael D. Taylor, Laura K. Donovan
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103078- (2024)
Summary: Here, we present a protocol for preclinical evaluation of locoregionally delivered CAR T cells in patient-derived xenograft models of primary, metastatic, and recurrent brain tumors. We provide instructions for isolating peripheral blood mon
Externí odkaz:
https://doaj.org/article/dc2222e4f824449c93ce23541c00e4e0
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-31 (2024)
Abstract Existing RNA velocity estimation methods strongly rely on predefined dynamics and cell-agnostic constant transcriptional kinetic rates, assumptions often violated in complex and heterogeneous single-cell RNA sequencing (scRNA-seq) data. Usin
Externí odkaz:
https://doaj.org/article/6cf53315e61f4c3ea3e7ec45154ee2dc
Autor:
Maxwell P. Gold, Winnie Ong, Andrew M. Masteller, David R. Ghasemi, Julie Anne Galindo, Noel R. Park, Nhan C. Huynh, Aneesh Donde, Veronika Pister, Raul A. Saurez, Maria C. Vladoiu, Grace H. Hwang, Tanja Eisemann, Laura K. Donovan, Adam D. Walker, Joseph Benetatos, Christelle Dufour, Livia Garzia, Rosalind A. Segal, Robert J. Wechsler-Reya, Jill P. Mesirov, Andrey Korshunov, Kristian W. Pajtler, Scott L. Pomeroy, Olivier Ayrault, Shawn M. Davidson, Jennifer A. Cotter, Michael D. Taylor, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the cerebellum, and we hypothesized that the heterogeneity observed in MBs with sonic hed
Externí odkaz:
https://doaj.org/article/7e7b389f322c4aed99ee994b5589418d
Autor:
Menglang Yuan, Iqbal Mahmud, Keisuke Katsushima, Kandarp Joshi, Olivier Saulnier, Rudramani Pokhrel, Bongyong Lee, Wathsala Liyanage, Haritha Kunhiraman, Stacie Stapleton, Ignacio Gonzalez-Gomez, Rangaramanujam M. Kannan, Tanja Eisemann, Elayaraja Kolanthai, Sudipta Seal, Timothy J. Garrett, Saed Abbasi, Kimberly Bockley, Justin Hanes, Prem Chapagain, George Jallo, Robert J. Wechsler-Reya, Michael D. Taylor, Charles G. Eberhart, Animesh Ray, Ranjan J. Perera
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract The prognosis of childhood medulloblastoma (MB) is often poor, and it usually requires aggressive therapy that adversely affects quality of life. microRNA-211 (miR-211) was previously identified as an important regulator of cells that descen
Externí odkaz:
https://doaj.org/article/d02fc40d411f4baba42e490fbec01155
Autor:
Keisuke Katsushima, Kandarp Joshi, Menglang Yuan, Brigette Romero, Mona Batish, Stacie Stapleton, George Jallo, Elayaraja Kolanthai, Sudipta Seal, Olivier Saulnier, Michael D. Taylor, Robert J. Wechsler-Reya, Charles G. Eberhart, Ranjan J. Perera
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113938- (2024)
Summary: Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma (MB) formation and progression. We have identified an lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) MBs. lnc-HLX-2-7 RNA specif
Externí odkaz:
https://doaj.org/article/4f95873122404b64823c7c17eb939dbe
Autor:
Shubin W. Shahab, Christianna M. Roggeveen, Jiarong Sun, Haritha Kunhiraman, Leon F. McSwain, Kyle Juraschka, Sachin A. Kumar, Olivier Saulnier, Michael D. Taylor, Matthew Schniederjan, Robert W. Schnepp, Tobey J MacDonald, Anna Marie Kenney
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1784-1802 (2023)
Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do not survive beyond 5 years after diagnosis. A factor that may contribute to this is the lack of available targeted therapy. Expression of protein lin‐28 homolog B
Externí odkaz:
https://doaj.org/article/93a4f4cb469a4d629a58e2ccc4aa8c54
Autor:
Zhe Jiang, YoungJun Ju, Amjad Ali, Philip E. D. Chung, Patryk Skowron, Dong-Yu Wang, Mariusz Shrestha, Huiqin Li, Jeff C. Liu, Ioulia Vorobieva, Ronak Ghanbari-Azarnier, Ethel Mwewa, Marianne Koritzinsky, Yaacov Ben-David, James R. Woodgett, Charles M. Perou, Adam Dupuy, Gary D. Bader, Sean E. Egan, Michael D. Taylor, Eldad Zacksenhaus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive anima
Externí odkaz:
https://doaj.org/article/141fc3ada18346a59e6af3fd9ea5bbbb
Autor:
Hieu T. Ta, Paul J. Critser, Michal Schäfer, Nicholas J. Ollberding, Michael D. Taylor, Michael V. Di Maria, Russel Hirsch, D. Dunbar Ivy, Benjamin S. Frank
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-9 (2023)
Abstract Background Multiple right ventricular (RV) metrics have prognostic value in pulmonary hypertension (PH). A cardiac magnetic resonance imaging (CMR) derived global ventricular function index (GFI) provided improved prediction of composite adv
Externí odkaz:
https://doaj.org/article/364cb5e4e47344afbca9d27500d21eb7