Zobrazeno 1 - 10
of 871
pro vyhledávání: '"Michael D, Smith"'
Autor:
Edward P. Feener, Rebecca L. Davie, Nivetha Murugesan, Stephen J. Pethen, Sally L. Hampton, Michael D. Smith, Paul K. Audhya, Chris M. Yea
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 2, Pp 328-341 (2024)
Sebetralstat is a novel, potent, and selective oral plasma kallikrein inhibitor drug candidate in clinical development for the on-demand treatment of hereditary angioedema (HAE). Upon binding, sebetralstat induces a conformational change in the activ
Externí odkaz:
https://doaj.org/article/c898ea85087542009c61e6fcd2741b8b
Vast cavities in the intergalactic medium are excavated by radio galaxies. The cavities appear as such in X-ray images because the external medium has been swept up, leaving a hot but low density bubble surrounding the radio lobes. We explore here th
Externí odkaz:
http://arxiv.org/abs/2101.03517
Autor:
Danny M. Cohn, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Henriette Farkas, William R. Lumry, Marcus Maurer, Andrea Zanichelli, Matthew Iverson, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, Marc A. Riedl
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 9, Pp n/a-n/a (2023)
Abstract Background Hereditary angioedema (HAE) with C1‐inhibitor deficiency (HAE‐C1‐INH) is characterized by recurrent, debilitating episodes of swelling. Sebetralstat, an investigational oral plasma kallikrein inhibitor, demonstrated promisin
Externí odkaz:
https://doaj.org/article/fa5357d5066e444bb5ad301768e9507f
Humanity has long been fascinated by the planet Mars. Was its climate ever conducive to life? What is the atmosphere like today and why did it change so dramatically over time? Eleven spacecraft have successfully flown to Mars since the Viking missio
Autor:
Aurélien Stcherbinine, Christopher S. Edwards, Michael D. Smith, Michael J. Wolff, Christopher Haberle, Eman Al Tunaiji, Nathan M. Smith, Kezman Saboi, Saadat Anwar, Lucas Lange, Philip R. Christensen
Publikováno v:
Geophysical Research Letters, Vol 50, Iss 12, Pp n/a-n/a (2023)
Abstract Condensation and sublimation of ices at the surface of the planet is a key part of both the Martian H2O and CO2 cycles, either from a seasonal or diurnal aspect. While most of the ice is located within the polar caps, surface frost is known
Externí odkaz:
https://doaj.org/article/960b724309024c7882e6aea79dd15066
Autor:
Michael D. Smith, Rahul Telang
How big data is transforming the creative industries, and how those industries can use lessons from Netflix, Amazon, and Apple to fight back.“[The authors explain] gently yet firmly exactly how the internet threatens established ways and what can a
Autor:
Deniz Marti, Michael D. Smith
Publikováno v:
Harvard Data Science Review, Vol 5, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/9e41f623f41b43628f0a5c8207e1b1b2
Autor:
Siteng Fan, François Forget, Michael D. Smith, Sandrine Guerlet, Khalid M. Badri, Samuel A. Atwood, Roland M. B. Young, Christopher S. Edwards, Philip R. Christensen, Justin Deighan, Hessa R. Al Matroushi, Antoine Bierjon, Jiandong Liu, Ehouarn Millour
Publikováno v:
Geophysical Research Letters, Vol 49, Iss 18, Pp n/a-n/a (2022)
Abstract Temperature profiles retrieved using the first set of data of the Emirates Mars InfraRed Spectrometer obtained during the science phase of the Emirates Mars Mission are used for the analysis of migrating thermal tides in the Martian atmosphe
Externí odkaz:
https://doaj.org/article/1112f6240e654ed08356f2fd5b9fafe9
Autor:
Michael J. Wolff, Anton Fernando, Michael D. Smith, François Forget, Ehouarn Millour, Samuel A. Atwood, Andrew R. Jones, Mikki M. Osterloo, Ralph Shuping, Mariam Al Shamsi, Christian Jeppesen, Charles Fisher
Publikováno v:
Geophysical Research Letters, Vol 49, Iss 18, Pp n/a-n/a (2022)
Abstract Observations by the Emirates eXploration Imager (EXI) on‐board the Emirates Mars Mission are used to characterize the diurnal, seasonal, and spatial behavior of aphelion cloud belt during Mars Year 36 LS ∼ 30°–190°. Building from pre
Externí odkaz:
https://doaj.org/article/c29f0acea3144192871a124d856548e5
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Eshita Khera, Cornelius Cilliers, Michael D. Smith, Michelle L. Ganno, Katharine C. Lai, Thomas A. Keating, Anna Kopp, Ian Nessler, Adnan O. Abu-Yousif, Greg M. Thurber
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Externí odkaz:
https://doaj.org/article/a1d49a829b1446a5941d3e371fc652ef