Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

Autor: Michael D Schultz, Tulin Dadali, Sylvain A Jacques, Hélène Muller-Steffner, Jeremy B Foote, Leonardo Sorci, Esther Kellenberger, Davide Botta, Frances E Lund

Publikováno v: PLoS Pathogens, Vol 16, Iss 5, p e1008539 (2020)

NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for de novo NAD biosynthesis, we evaluated whether these parasites, which infect >200 million pe

Externí odkaz: https://doaj.org/article/38618719737b47b3b9c46e6de53e10de

Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission

Autor: Madeleine F. Jennewein, Michael D. Schultz, Samuel Beaver, Peter Battisti, Julie Bakken, Derek Hanson, Jobaida Akther, Raodoh Mohamath, Jasneet Singh, Noah Cross, Sierra Reed, Davies Kalange, Jeremy B. Foote, R. Glenn King, Aaron Silva-Sanchez, Davide Botta, Alana Gerhardt, Corey Casper, Troy D. Randall, Frances E. Lund, Emily A. Voigt

While mRNA vaccines have been effective in combating SARS-CoV-2, waning of vaccine-induced antibody responses and lack of vaccine-induced respiratory tract immunity contribute to ongoing infection and transmission. In this work, we compare and contra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf96c4195ec323dc2a0735968d33964
https://doi.org/10.1101/2022.11.10.515993

Lung dendritic cells migrate to the spleen to prime long-lived TCF1

Autor: Meagan M, Jenkins, Holly, Bachus, Davide, Botta, Michael D, Schultz, Alexander F, Rosenberg, Beatriz, León, André, Ballesteros-Tato

Publikováno v: Sci Immunol

CD8(+) T cell responses to pulmonary challenges are primed by lung migratory dendritic cells (mDCs), which capture antigens in the lungs and migrate to the lung-draining mediastinal lymph node (med-LN) to activate T cells. Notably, the lungs and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5381d8228790f4c6c0e39fd4449c1878
https://pubmed.ncbi.nlm.nih.gov/34516781

The establishment of resident memory B cells in the lung requires local antigen encounter

Autor: Beth A. Graf, Frances E. Lund, Michael D. Schultz, S. Rameeza Allie, Uma Mudunuru, John E. Bradley, Troy D. Randall

Publikováno v: Nature immunology

Memory B cells are found in lymphoid and non-lymphoid tissues, suggesting that some may be tissue-resident cells. Here we show that pulmonary influenza infection elicited lung-resident memory B cells (BRM cells) that were phenotypically and functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3759d0ffd346806e924aa215ae308bd3
https://doi.org/10.1038/s41590-018-0260-6

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

Autor: Jeremy B. Foote, Hélène Muller-Steffner, Davide Botta, Sylvain A. Jacques, Leonardo Sorci, Frances E. Lund, Tulin Dadali, Michael D. Schultz, Esther Kellenberger

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2020, 16 (5), pp.e1008539. ⟨10.1371/journal.ppat.1008539⟩
PLoS Pathogens, Vol 16, Iss 5, p e1008539 (2020)

NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for de novo NAD biosynthesis, we evaluated whether these parasites, which infect >200 million pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20ecca6a432763778842c9c459bf2b9
https://hal.archives-ouvertes.fr/hal-03021592