Výsledky vyhledávání - "Michael D, Milsom"

Akademický článek

EVI1-mediated Programming of Normal and Malignant Hematopoiesis

Publikováno v: HemaSphere, Vol 7, Iss 10, p e959 (2023)

Ecotropic viral integration site 1 (EVI1), encoded at the MECOM locus, is an oncogenic zinc finger transcription factor with diverse roles in normal and malignant cells, most extensively studied in the context of hematopoiesis. EVI1 interacts with ot

Externí odkaz: https://doaj.org/article/7ec5f4bd77d44b719600b6bdbe305334

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Akademický článek

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

Autor: Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, Ute Modlich

Publikováno v: Cell Reports, Vol 41, Iss 1, Pp 111447- (2022)

Summary: Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and pr

Externí odkaz: https://doaj.org/article/4f2b90b0b8ec49f9816a17097e7b27e9

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The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells

Autor: Deepti Talwar, Colin G. Miller, Justus Grossmann, Lukasz Szyrwiel, Torsten Schwecke, Vadim Demichev, Ana-Matea Mikecin Drazic, Anand Mayakonda, Pavlo Lutsik, Carmen Veith, Michael D. Milsom, Karin Müller-Decker, Michael Mülleder, Markus Ralser, Tobias P. Dick

Publikováno v: Nature Metabolism. 5:660-676

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading to rapid inactivation of the enzyme. Here we show that human and mouse cells expressin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4874348d43578ad40f44fe3760e1e2d
https://doi.org/10.1038/s42255-023-00781-3

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Akademický článek

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Autor: Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann

Publikováno v: Haematologica, Vol 106, Iss 5 (2020)

Hematopoietic development is spatiotemporally tightly regulated by defined cell-intrinsic and extrinsic modifiers. The role of cytokines has been intensively studied in adult hematopoiesis; however, their role in embryonic hematopoietic specification

Externí odkaz: https://doaj.org/article/a74ac7cd574543a09df90921c75da6e4

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