Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Michael D, Kahl"'
Autor:
Erin M. Maloney, Daniel L. Villeneuve, Kathleen M. Jensen, Brett R. Blackwell, Michael D. Kahl, Shane T. Poole, Kelsey Vitense, David J. Feifarek, Grace Patlewicz, Kendra Dean, Charlene Tilton, Eric C. Randolph, Jenna E. Cavallin, Carlie A. LaLone, Donovan Blatz, Christopher M. Schaupp, Gerald T. Ankley
Publikováno v:
Environmental Toxicology and Chemistry. 42:1229-1256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2194a7a7c690e5ca65aae8f9735908
https://doi.org/10.1002/etc.5571
https://doi.org/10.1002/etc.5571
Autor:
Daniel L. Villeneuve, Brett R. Blackwell, Jenna E. Cavallin, Jacob Collins, John X. Hoang, Rachel N. Hofer, Keith A. Houck, Kathleen M. Jensen, Michael D. Kahl, Robin N. Kutsi, Anne S. Opseth, Kelvin J. Santana Rodriguez, Christopher Schaupp, Emma H. Stacy, Gerald T. Ankley
Publikováno v:
Environmental Science & Technology. 57:3794-3803
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e77c7a83ae8b012ee9c261654a57317
https://doi.org/10.1021/acs.est.2c09315
https://doi.org/10.1021/acs.est.2c09315
Autor:
Brett R. Blackwell, Shane T. Poole, Kathleen M. Jensen, Jenna E. Cavallin, Jonathan D. Mosley, Kellie A. Fay, J. Swintek, Timothy W. Collette, Daniel C. Rearick, Drew R. Ekman, Michael D. Kahl, Eric C. Randolph, Jason P. Berninger, Gerald T. Ankley, Anthony L. Schroeder, Daniel L. Villeneuve, David J Feifarek
Publikováno v:
Environ Toxicol Chem
Assessment of ecological risks of chemicals in the field usually involves complex mixtures of known and unknown compounds. We describe the use of pathway-based chemical and biological approaches to assess the risk of chemical mixtures in the Maumee R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c86b6ddb2680a05344a53dab8d3a87
https://doi.org/10.1002/etc.4949
https://doi.org/10.1002/etc.4949
Autor:
Daniel L. Villeneuve, Brett R. Blackwell, Chad A. Blanksma, Jenna E. Cavallin, Wan‐Yun Cheng, Rory B. Conolly, Kendra Conrow, David J. Feifarek, Larry J. Heinis, Kathleen M. Jensen, Michael D. Kahl, Rebecca Y. Milsk, Shane T. Poole, Eric C. Randolph, Travis W. Saari, Karen H. Watanabe, Gerald T. Ankley
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 42(1)
To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach methodologies (NAMs) that provide relevant scientific information at a quality equivalent to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abec59100887e4e6dc1e05f3bac264aa
https://pubmed.ncbi.nlm.nih.gov/36282016
https://pubmed.ncbi.nlm.nih.gov/36282016
Autor:
Brett R. Blackwell, Gerald T. Ankley, Adam D. Biales, Jenna E. Cavallin, Alexander R. Cole, Timothy W. Collette, Drew R. Ekman, Rachel N. Hofer, Weichun Huang, Kathleen M. Jensen, Michael D. Kahl, Ashley R. Kittelson, Shannon N. Romano, Mary Jean See, Quincy Teng, Charlene B. Tilton, Daniel L. Villeneuve
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 41(11)
Metformin, along with its biotransformation product guanylurea, is commonly observed in municipal wastewaters and subsequent surface waters. Previous studies in fish have identified metformin as a potential endocrine-active compound, but there are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b0c2e0d3eeb1787e7262da3bd79332
https://pubmed.ncbi.nlm.nih.gov/35920346
https://pubmed.ncbi.nlm.nih.gov/35920346
Autor:
Shane T. Poole, Brett R. Blackwell, Jenna E. Cavallin, Michael D. Kahl, David J Feifarek, Kathleen M. Jensen, Eric C. Randolph, Travis W. Saari, Jon A. Doering, Carlie A. LaLone, Daniel L. Villeneuve, Gerald T. Ankley
Publikováno v:
Environ Toxicol Chem
Predictive approaches to assessing the toxicity of contaminant mixtures have been largely limited to chemicals that exert effects through the same biological molecular initiating event. However, by understanding specific pathways through which chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78895fe856a1ef90c6891594bcbba4cb
https://doi.org/10.1002/etc.4668
https://doi.org/10.1002/etc.4668
Autor:
Eric C. Randolph, Carlie A. LaLone, Michael D. Kahl, Kellie A. Fay, Jon A. Doering, Daniel L. Villeneuve, Gerald T. Ankley, Kathleen M. Jensen
Publikováno v:
Toxicological Sciences. 170:394-403
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the conversion of androgens to estrogens. Inhibition of aromatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99424744880907560d49ee204ae65e44
https://doi.org/10.1093/toxsci/kfz115
https://doi.org/10.1093/toxsci/kfz115
Autor:
Jenna E. Cavallin, Gerald T. Ankley, Anthony L. Schroeder, Eric C. Randolph, Michael D. Kahl, Chad A. Blanksma, Daniel L. Villeneuve, Shane T. Poole, Patricia A. Kosian, Kellie A. Fay, Kathleen M. Jensen, Dries Knapen, Brett R. Blackwell, Lucia Vergauwen
Publikováno v:
Environmental Toxicology and Chemistry. 36:2942-2952
Inflation of the posterior and/or anterior swim bladder are processes previously demonstrated to be thyroid-hormone regulated. We investigated whether inhibition of deiodinases, which convert thyroxine (T4) to the more biologically-active form, 3,5,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1cfd654a650030419589f436517949f
https://doi.org/10.1002/etc.3855
https://doi.org/10.1002/etc.3855
Autor:
Nancy D. Denslow, Quincy Teng, John M. Davis, Jason P. Berninger, Alvine C. Mehinto, Dalma Martinović-Weigelt, Kathleen M. Jensen, Drew R. Ekman, Carlie A. LaLone, Michael D. Kahl, Gerald T. Ankley, Evan Eid, Elizabeth J. Durhan, Daniel L. Villeneuve, Timothy W. Collette
Publikováno v:
Toxicological Sciences. 156:344-361
Cyclooxygenase (COX) inhibitors are ubiquitous in aquatic systems and have been detected in fish tissues. The exposure of fish to these pharmaceuticals is concerning because COX inhibitors disrupt the synthesis of prostaglandins (PGs), which modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d97b482dc627ca163300ff99d03cc9
https://doi.org/10.1093/toxsci/kfw257
https://doi.org/10.1093/toxsci/kfw257
Autor:
Ashley R. Kittelson, Shane T. Poole, Kathleen M. Jensen, Charlene B. Tilton, Jon A. Doering, Gerald T. Ankley, Brett R. Blackwell, Carlie A. LaLone, Michael D. Kahl, Daniel L. Villeneuve, David J Feifarek
Publikováno v:
Environmental sciencetechnology. 53(17)
Quantitative adverse outcome pathways (qAOPs) describe quantitative response-response relationships that can predict the probability or severity of an adverse outcome for a given magnitude of chemical interaction with a molecular initiating event. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6075a09bf638725e89fe22e00b2e93d9
https://pubmed.ncbi.nlm.nih.gov/31386814
https://pubmed.ncbi.nlm.nih.gov/31386814