Výsledky vyhledávání - "Michael D, Kahl"

Pathway‐Based Approaches for Assessing Biological Hazards of Complex Mixtures of Contaminants: A Case Study in the Maumee River

Autor: Brett R. Blackwell, Shane T. Poole, Kathleen M. Jensen, Jenna E. Cavallin, Jonathan D. Mosley, Kellie A. Fay, J. Swintek, Timothy W. Collette, Daniel C. Rearick, Drew R. Ekman, Michael D. Kahl, Eric C. Randolph, Jason P. Berninger, Gerald T. Ankley, Anthony L. Schroeder, Daniel L. Villeneuve, David J Feifarek

Publikováno v: Environ Toxicol Chem

Assessment of ecological risks of chemicals in the field usually involves complex mixtures of known and unknown compounds. We describe the use of pathway-based chemical and biological approaches to assess the risk of chemical mixtures in the Maumee R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c86b6ddb2680a05344a53dab8d3a87
https://doi.org/10.1002/etc.4949

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Case Study in 21st-Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo

Autor: Daniel L. Villeneuve, Brett R. Blackwell, Chad A. Blanksma, Jenna E. Cavallin, Wan‐Yun Cheng, Rory B. Conolly, Kendra Conrow, David J. Feifarek, Larry J. Heinis, Kathleen M. Jensen, Michael D. Kahl, Rebecca Y. Milsk, Shane T. Poole, Eric C. Randolph, Travis W. Saari, Karen H. Watanabe, Gerald T. Ankley

Publikováno v: Environmental toxicology and chemistryREFERENCES. 42(1)

To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach methodologies (NAMs) that provide relevant scientific information at a quality equivalent to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abec59100887e4e6dc1e05f3bac264aa
https://pubmed.ncbi.nlm.nih.gov/36282016

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Effects of Metformin and its Metabolite Guanylurea on Fathead Minnow (Pimephales promelas) Reproduction

Autor: Brett R. Blackwell, Gerald T. Ankley, Adam D. Biales, Jenna E. Cavallin, Alexander R. Cole, Timothy W. Collette, Drew R. Ekman, Rachel N. Hofer, Weichun Huang, Kathleen M. Jensen, Michael D. Kahl, Ashley R. Kittelson, Shannon N. Romano, Mary Jean See, Quincy Teng, Charlene B. Tilton, Daniel L. Villeneuve

Publikováno v: Environmental toxicology and chemistryREFERENCES. 41(11)

Metformin, along with its biotransformation product guanylurea, is commonly observed in municipal wastewaters and subsequent surface waters. Previous studies in fish have identified metformin as a potential endocrine-active compound, but there are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b0c2e0d3eeb1787e7262da3bd79332
https://pubmed.ncbi.nlm.nih.gov/35920346

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Adverse Outcome Pathway Network–Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function

Autor: Shane T. Poole, Brett R. Blackwell, Jenna E. Cavallin, Michael D. Kahl, David J Feifarek, Kathleen M. Jensen, Eric C. Randolph, Travis W. Saari, Jon A. Doering, Carlie A. LaLone, Daniel L. Villeneuve, Gerald T. Ankley

Publikováno v: Environ Toxicol Chem

Predictive approaches to assessing the toxicity of contaminant mixtures have been largely limited to chemicals that exert effects through the same biological molecular initiating event. However, by understanding specific pathways through which chemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78895fe856a1ef90c6891594bcbba4cb
https://doi.org/10.1002/etc.4668

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Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase (CYP19) Activity Among 18 Freshwater Fishes

Autor: Eric C. Randolph, Carlie A. LaLone, Michael D. Kahl, Kellie A. Fay, Jon A. Doering, Daniel L. Villeneuve, Gerald T. Ankley, Kathleen M. Jensen

Publikováno v: Toxicological Sciences. 170:394-403

There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the conversion of androgens to estrogens. Inhibition of aromatase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99424744880907560d49ee204ae65e44
https://doi.org/10.1093/toxsci/kfz115

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Impaired swim bladder inflation in early life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid

Autor: Jenna E. Cavallin, Gerald T. Ankley, Anthony L. Schroeder, Eric C. Randolph, Michael D. Kahl, Chad A. Blanksma, Daniel L. Villeneuve, Shane T. Poole, Patricia A. Kosian, Kellie A. Fay, Kathleen M. Jensen, Dries Knapen, Brett R. Blackwell, Lucia Vergauwen

Publikováno v: Environmental Toxicology and Chemistry. 36:2942-2952

Inflation of the posterior and/or anterior swim bladder are processes previously demonstrated to be thyroid-hormone regulated. We investigated whether inhibition of deiodinases, which convert thyroxine (T4) to the more biologically-active form, 3,5,3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1cfd654a650030419589f436517949f
https://doi.org/10.1002/etc.3855

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Derivation and Evaluation of Putative Adverse Outcome Pathways for the Effects of Cyclooxygenase Inhibitors on Reproductive Processes in Female Fish

Autor: Nancy D. Denslow, Quincy Teng, John M. Davis, Jason P. Berninger, Alvine C. Mehinto, Dalma Martinović-Weigelt, Kathleen M. Jensen, Drew R. Ekman, Carlie A. LaLone, Michael D. Kahl, Gerald T. Ankley, Evan Eid, Elizabeth J. Durhan, Daniel L. Villeneuve, Timothy W. Collette

Publikováno v: Toxicological Sciences. 156:344-361

Cyclooxygenase (COX) inhibitors are ubiquitous in aquatic systems and have been detected in fish tissues. The exposure of fish to these pharmaceuticals is concerning because COX inhibitors disrupt the synthesis of prostaglandins (PGs), which modulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d97b482dc627ca163300ff99d03cc9
https://doi.org/10.1093/toxsci/kfw257

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Quantitative Response-Response Relationships Linking Aromatase Inhibition to Decreased Fecundity are Conserved Across Three Fishes with Asynchronous Oocyte Development

Autor: Ashley R. Kittelson, Shane T. Poole, Kathleen M. Jensen, Charlene B. Tilton, Jon A. Doering, Gerald T. Ankley, Brett R. Blackwell, Carlie A. LaLone, Michael D. Kahl, Daniel L. Villeneuve, David J Feifarek

Publikováno v: Environmental sciencetechnology. 53(17)

Quantitative adverse outcome pathways (qAOPs) describe quantitative response-response relationships that can predict the probability or severity of an adverse outcome for a given magnitude of chemical interaction with a molecular initiating event. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6075a09bf638725e89fe22e00b2e93d9
https://pubmed.ncbi.nlm.nih.gov/31386814

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