Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael Cwik"'
Publikováno v:
Bioanalysis. 14:137-149
The quantitation of PTH-Fc in circulation by ligand binding assay presented a significant challenge due to the extremely low doses of administration, interference from the endogenous. A robust LC–MS/MS method to quantify the extremely low concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28c0e7a6565ed08441d1f9f0288feec
https://doi.org/10.4155/bio-2021-0233
https://doi.org/10.4155/bio-2021-0233
Autor:
Chunlin Chen, Liming Zhang, Cristina Almansa, Maria Rosario, Michael Cwik, Suresh K. Balani, Ruth Lock
Publikováno v:
Clinical Pharmacology in Drug Development. 11:142-149
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed0148232455abedda7b8df16bcec530
https://doi.org/10.1002/cpdd.1046
https://doi.org/10.1002/cpdd.1046
Publikováno v:
British Journal of Clinical Pharmacology
Aims Soticlestat is a first-in-class selective inhibitor of cholesterol 24-hydroxylase, the enzyme that converts brain cholesterol to 24S-hydroxycholesterol (24HC), a positive allosteric modulator of N-methyl-D-aspartate receptors. Soticlestat is und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0db4de110188f9846d73125cfb3b9
https://doi.org/10.1111/bcp.14854
https://doi.org/10.1111/bcp.14854
Publikováno v:
British journal of clinical pharmacology. 88(6)
Soticlestat, a first-in-class inhibitor of cholesterol 24-hydroxylase (also known as cytochrome P450 46A1), is currently in development for the treatment of developmental and epileptic encephalopathies. Here, we report safety, tolerability, pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db15aebf61c18a95c38cbe6798a3886b
https://pubmed.ncbi.nlm.nih.gov/35001412
https://pubmed.ncbi.nlm.nih.gov/35001412
Autor:
Michael Cwik, L. E. Hong, Dmitri Volfson, Wyatt Marshall, Ann Summerfelt, Patricio O'Donnell, Maria S. Quinton, Peter Kochunov, Mark D. Kvarta, Eric L. Goldwaser, Joshua Chiappelli, Heather Bruce
Publikováno v:
npj Schizophrenia, Vol 6, Iss 1, Pp 1-6 (2020)
NPJ Schizophrenia
NPJ Schizophrenia
Plasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain structures, 24S-hydroxycholesterol is a prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4901bd71557a122ddf16caece2b33be9
https://doi.org/10.1038/s41537-020-00121-4
https://doi.org/10.1038/s41537-020-00121-4
Autor:
Guodong Zhang, Michael Cwik, Jonathan A. Bernstein, Yongquan Lai, Priya S. Chockalingam, Neil Inhaber, Jiang Wu, Zhiwei Zhou
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 195
Hereditary angioedema (HAE) is a rare genetic disease caused by deficiency or dysfunction of C1 esterase inhibitor (C1-INH). Plasma C1-INH activity and concentrations of C1-INH and complement components 1q and 4 (C1q, C4) are critical to the HAE diag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd64204b1f710cbabeb4964d7b8caa19
https://pubmed.ncbi.nlm.nih.gov/33388640
https://pubmed.ncbi.nlm.nih.gov/33388640
Autor:
Chunlin, Chen, Liming, Zhang, Cristina, Almansa, Maria, Rosario, Michael, Cwik, Suresh K, Balani, Ruth, Lock
Publikováno v:
Clinical pharmacology in drug developmentReferences. 11(2)
The 5-hydroxytryptamine type-4 receptor agonist felcisetrag (TAK-954) is being investigated for improving gastrointestinal motility in postoperative gastrointestinal dysfunction. Polypharmacy often occurs in this setting, and as in vitro data indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f4ceb7138af0ec6c209cc349dcfef3f
https://pubmed.ncbi.nlm.nih.gov/34989180
https://pubmed.ncbi.nlm.nih.gov/34989180
Autor:
Richard G. Gilbert, Fred J. Brenner, Michael Cwik, R. D. Estes, R. S. Dorney, S. Ramamoorthy, James W. Moore
Publikováno v:
Environmental Management. 6:361-366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d769ffd7298b6367d6a5a01d53f4ec61
https://doi.org/10.1007/bf01875069
https://doi.org/10.1007/bf01875069