Calcium handling abnormalities increase arrhythmia susceptibility in DMSXL myotonic dystrophy type 1 mice

Autor: Michael Cupelli, Vamsi Krishna Murthy Ginjupalli, Jean-Baptiste Reisqs, Yvonne Sleiman, Nabil El-Sherif, Geneviève Gourdon, Jack Puymirat, Mohamed Chahine, Mohamed Boutjdir

Publikováno v: Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117562- (2024)

Background: Myotonic dystrophy type 1 (DM1) is a multiorgan disorder with significant cardiac involvement. ECG abnormalities, including arrhythmias, occur in 80 % of DM1 patients and are the second-most common cause of death after respiratory complic

Externí odkaz: https://doaj.org/article/e711d93d90794eb9828e3a96b068756f

Electrophysiological basis of cardiac arrhythmia in a mouse model of myotonic dystrophy type 1

Autor: Vamsi Krishna Murthy Ginjupalli, Michael Cupelli, Jean-Baptiste Reisqs, Yvonne Sleiman, Nabil El-Sherif, Genevieve Gourdon, Jack Puymirat, Mohamed Chahine, Mohamed Boutjdir

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Introduction: Myotonic dystrophy type 1 (DM1) is a multisystemic genetic disorder caused by the increased number of CTG repeats in 3′ UTR of Dystrophia Myotonia Protein Kinase (DMPK) gene. DM1 patients experience conduction abnormalities as well as

Externí odkaz: https://doaj.org/article/0e83e010915a4304aa31e83301e517c2

Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells

Autor: Mohammed Djemai, Michael Cupelli, Mohamed Boutjdir, Mohamed Chahine

Publikováno v: Cells, Vol 12, Iss 17, p 2168 (2023)

Optical mapping is a powerful imaging technique widely adopted to measure membrane potential changes and intracellular Ca2+ variations in excitable tissues using voltage-sensitive dyes and Ca2+ indicators, respectively. This powerful tool has rapidly

Externí odkaz: https://doaj.org/article/5695b73a665f43a68290edd854724c52

Voltage/Calcium Uncoupling Underlies Sustained Torsade de Pointes Ventricular Tachyarrhythmia in an Experimental Model of Long QT Syndrome

Autor: Herman D. Himel, Michael Cupelli, Mohamed Boutjdir, Nabil El-Sherif

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

BackgroundClinical experience showed that the majority of Torsade de Pointes (TdP) ventricular tachyarrhythmia (VT) in patients with long QT syndrome (LQTS) are self-terminating (ST), but the few that are non-self-terminating (NST) are potentially fa

Externí odkaz: https://doaj.org/article/5ccbc24d20f94e1f8dc1e69ed89cdf12

Unravelling Atrioventricular Block Risk in Inflammatory Diseases: Systemic Inflammation Acutely Delays Atrioventricular Conduction via a Cytokine-Mediated Inhibition of Connexin43 Expression

Autor: Alessandro Frosali, Decoroso Verrengia, Alessandra Gamberucci, Mohamed Boutjdir, Francesca Vanni, Franco Laghi-Pasini, Aleksander Dokollari, Pier Leopoldo Capecchi, Alessandra Cartocci, Maurizio Acampa, Nabil El-Sherif, Claudio Nanni, Antonio D'Errico, Pietro Enea Lazzerini, Ujala Srivastava, Iacopo Bertolozzi, Anna Cantore, Michael Cupelli, Fabio Salvadori, Viola Salvini, Riccardo Accioli, Massimo Maccherini

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)

Background Recent data suggest that systemic inflammation can negatively affect atrioventricular conduction, regardless of acute cardiac injury. Indeed, gap‐junctions containing connexin43 coupling cardiomyocytes and inflammation‐related cells (m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a14dc0ad90d1930ab3b7ed13e58cc2a
https://pubmed.ncbi.nlm.nih.gov/34713715