Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael Constantinides"'
Autor:
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coënon, Caroline Multrier, Loïc Vaillant, Julien Peyroux, Tianxiang Zhang, Martin Villalba
Publikováno v:
MedComm, Vol 5, Iss 10, Pp n/a-n/a (2024)
Abstract Natural killer (NK) cells are candidates for adoptive cell therapy, and the protocols for their activation and expansion profoundly influence their function and fate. The complexity of NK cell origin and feeder cell cues impacts the heteroge
Externí odkaz:
https://doaj.org/article/20307a4e5928439fb83ade7261f80127
Autor:
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coenon, Caroline Multrier, Loïc Vaillant, Tianxiang Zhang, Martin Villalba
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTFcRγ-deficient natural killer (NK) cells, designated as g-NK cells, exhibit enhanced antibody-dependent cellular cytotoxicity (ADCC) capacity and increased IFN-γ and TNF-α production, rendering them promising for antiviral and antitumor re
Externí odkaz:
https://doaj.org/article/18bfa75847704b468022f8db43c398bd
Autor:
Mauricio Campos-Mora, William Jacot, Genevieve Garcin, Marie-Lise Depondt, Michael Constantinides, Catherine Alexia, Martin Villalba
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The innate immune lymphocyte lineage natural killer (NK) cell infiltrates tumor environment where it can recognize and eliminate tumor cells. NK cell tumor infiltration is linked to patient prognosis. However, it is unknown if some of these antitumor
Externí odkaz:
https://doaj.org/article/07508662fa764826b00eaea3446f8c8a
Autor:
Sana Belkahla, Joaquin Marco Brualla, Alexis Fayd’herbe de Maudave, Paolo Falvo, Nerea Allende-Vega, Michael Constantinides, Abrar Ul Haq Khan, Lois Coenon, Catherine Alexia, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Wissem Mnif, Javier Hernandez, Alberto Anel, Martin Villalba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Leukemic cells proliferate faster than non-transformed counterparts. This requires them to change their metabolism to adapt to their high growth. This change can stress cells and facilitate recognition by immune cells such as cytotoxic lymph
Externí odkaz:
https://doaj.org/article/0a6c7e5f1a1d4f84b4d02628999b7b05
Autor:
Nerea Allende-Vega, Joaquin Marco Brualla, Paolo Falvo, Catherine Alexia, Michael Constantinides, Alexis Fayd’herbe de Maudave, Lois Coenon, Delphine Gitenay, Giulia Mitola, Paul Massa, Stefania Orecchioni, Francesco Bertolini, Isabel Marzo, Alberto Anel, Martin Villalba
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of sol
Externí odkaz:
https://doaj.org/article/80ab263158524947a4f42174b3b1b555
Autor:
Giuseppe Fusi, Michael Constantinides, Christina Fissoun, Lydiane Pichard, Yves-Marie Pers, Rosanna Ferreira-Lopez, Veronique Pantesco, Christophe Poulet, Olivier Malaise, Dominique De Seny, Jean-Marc Lemaitre, Christian Jorgensen, Jean-Marc Brondello
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1994 (2023)
Senescent cells promote progressive tissue degeneration through the establishment of a combined inflammatory and trophic microenvironment. The cellular senescence state has therefore emerged as a central driving mechanism of numerous age-related dise
Externí odkaz:
https://doaj.org/article/821ba450a9aa49e8a33748357f4bf3d1
Autor:
Chantal Reina-Ortiz, Michael Constantinides, Alexis Fayd-Herbe-de-Maudave, Jessy Présumey, Javier Hernandez, Guillaume Cartron, David Giraldos, Rosana Díez, Isabel Izquierdo, Gemma Azaceta, Luis Palomera, Isabel Marzo, Javier Naval, Alberto Anel, Martín Villalba
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
In this study we evaluated the potential of expanded NK cells (eNKs) from two sources combined with the mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) cells ex vivo. In order to ascertain the best source of NK cells, we ex
Externí odkaz:
https://doaj.org/article/c66d7fd744d64dde8fe77da679284058
Autor:
Dang-Nghiem Vo, Michael Constantinides, Nerea Allende-Vega, Catherine Alexia, Guillaume Cartron, Martin Villalba
Publikováno v:
Vaccines, Vol 8, Iss 4, p 727 (2020)
The lymphocyte lineage natural killer (NK) cell is part of the innate immune system and protects against pathogens and tumor cells. NK cells are the main cell effectors of the monoclonal antibodies (mAbs) that mediates antibody-dependent cell cytotox
Externí odkaz:
https://doaj.org/article/7f538a2478974afb9c3aec47a6279532
The first edition of Theory of Valuation is a collection of important papers in the field of theoretical financial economics published from 1973 to 1986, and original accompanying essays contributed by eminent researchers including Robert C Merton, E
Autor:
Michael Constantinides, Alexis Fayd’herbe De Maudave, Marie Potier-Cartereau, Mauricio Campos-Mora, Guillaume Cartron, Martin Villalba
Publikováno v:
Cancers
Volume 15
Issue 4
Pages: 1109
Volume 15
Issue 4
Pages: 1109
CD20 monoclonal antibodies (mAbs) eliminate B cells in several clinical contexts. At least two of these Abs, obinutuzumab (OBI) and rituximab (RTX), induce quick elimination of targets and put cancer patients at risk of tumor lysis syndrome (TLS) wit