Výsledky vyhledávání - "Michael Conner"

Akademický článek

Emergence of the CD226 Axis in Cancer Immunotherapy

Autor: Michael Conner, Ken W. Hance, Sapna Yadavilli, James Smothers, Jeremy D. Waight

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

In recent years, a set of immune receptors that interact with members of the nectin/nectin-like (necl) family has garnered significant attention as possible points of manipulation in cancer. Central to this axis, CD226, TIGIT, and CD96 represent liga

Externí odkaz: https://doaj.org/article/de4cbba0e3fd4f49b752e681262c16cf

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Akademický článek

Feasibility of Utilizing PREMM Score for Lynch Syndrome Identification in an Urban, Minority Patient Population

Autor: Brigid Adviento, Michael Conner, Alexander Sarkisian, Nicolette Walano, Hans Andersson, Jordan Karlitz

Publikováno v: Journal of Primary Care & Community Health, Vol 12 (2021)

The PREMM 5 model is a web-based clinical prediction algorithm that estimates the gene-specific risk of an individual carrying a Lynch syndrome germline mutation based on targeted family history questions. The objectives of our study were to determin

Externí odkaz: https://doaj.org/article/2d8f06f5fe0b490f8bf7d3207d6051ea

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Akademický článek

Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments.

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206223 (2018)

Mouse syngeneic tumor models are widely used tools to demonstrate activity of novel anti-cancer immunotherapies. Despite their widespread use, a comprehensive view of their tumor-immune compositions and their relevance to human tumors has only begun

Externí odkaz: https://doaj.org/article/9e5e09f3952c4542877ca7afcf5e271e

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Supplementary Figure 4 from Effect of Niclosamide on Basal-like Breast Cancers

Autor: Donald J. Buchsbaum, Yonghe Li, Albert F. LoBuglio, Andres Forero-Torres, Michael Conner, William E. Grizzle, Bertha Hidalgo, Brandon J. Metge, Rajeev S. Samant, Wenyan Lu, Laura Aristizabal, Rebecca C. Arend, Angelina I. Londoño-Joshi

PDF file - 96KB, Supplementary Figure S4. Wnt/beta-catenin signaling proteins in LRP6 KD cells. Western blot for expression of Wnt/beta-catenin signaling proteins in adherent 2LMP shRNA LRP6 knockdown cells compared to shRNA control cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62391a1fdd262bc11149ca51aa330ba1
https://doi.org/10.1158/1535-7163.22501198.v1

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Data from Effect of Niclosamide on Basal-like Breast Cancers

Basal-like breast cancers (BLBC) are poorly differentiated and display aggressive clinical behavior. These tumors become resistant to cytotoxic agents, and tumor relapse has been attributed to the presence of cancer stem cells (CSC). One of the pathw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9fc754454330c6f71df77c99c1a53c4
https://doi.org/10.1158/1535-7163.c.6536704.v1

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Supplementary Figure 1 from Effect of Niclosamide on Basal-like Breast Cancers

PDF file - 128KB, Supplementary Figure S1. Sensitivity of MF10A mammary epithelial cells to niclosamide and TRA-8 mediated cytotoxicity. (A) Attached MCF10A cell line was treated for 48 hours with niclosamide (0.08, 0.1, 0.25 and 0.5 microM) and anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d0e09d6baeec9367ab372c9916dde0
https://doi.org/10.1158/1535-7163.22501207

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Supplementary Table 1 from Effect of Niclosamide on Basal-like Breast Cancers

PDF file - 89KB, Supplementary Table S1. Sensitivity of BLBC cell lines to niclosamide mediated cytotoxicity. SUM159, HCC1187, HCC1143 and 2LMP BLBC NAAE and adherent cell lines were treated with niclosamide for 48 hours and analyzed for viability us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a248301c09377c4d379a741b0c1f11fa
https://doi.org/10.1158/1535-7163.22501192

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Supplementary Table 2 from Effect of Niclosamide on Basal-like Breast Cancers

PDF file - 72KB, Supplementary Table S2. Immunohistochemistry of mouse tumors treated for two weeks with vehicle control, niclosamide (20 mg/kg), TRA-8 (200 micro-g) or the combination of both agents. Tumors were stained and analyzed (H-score) for p-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a922eb4c4848d5ba030dc2c207f1b3c
https://doi.org/10.1158/1535-7163.22501189

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