Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michael Cipriano"'
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105302- (2022)
Summary: NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which causes human African trypanosomiasis. Optimized with phenotypic screening, targets of NEU-4438 are unknown. Herein, we present a cell perturbome workflow that
Externí odkaz:
https://doaj.org/article/b96c537891464aeab088a311855fedc4
Autor:
Paige Garrison, Umaer Khan, Michael Cipriano, Peter J. Bush, Jacquelyn McDonald, Aakash Sur, Peter J. Myler, Terry K. Smith, Stephen L. Hajduk, James D. Bangs
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific pho
Externí odkaz:
https://doaj.org/article/bf9bd0020fb4404db69135c5e3a5c6f5
Autor:
Catherine Suarez, Gaëlle Lentini, Raghavendran Ramaswamy, Marjorie Maynadier, Eleonora Aquilini, Laurence Berry-Sterkers, Michael Cipriano, Allan L. Chen, Peter Bradley, Boris Striepen, Martin J. Boulanger, Maryse Lebrun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids,
Externí odkaz:
https://doaj.org/article/5d7eb981430d428a86981e90c449cc6b
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1566 (2008)
The editing of trypanosome mitochondrial mRNAs produces transcripts necessary for mitochondrial functions including electron transport and oxidative phosphorylation. Precursor-mRNAs are often extensively edited by specific uridine insertion or deleti
Externí odkaz:
https://doaj.org/article/f2dbbf0e81684a06a02a1b9b64362e59
Autor:
William S. Kisaalita, Wujun Zhao, Michael Cipriano, Kenneth Ndyabawe, Mark A. Haidekker, Kun Yao, Leidong Mao
Publikováno v:
ACS Biomaterials Science & Engineering. 7:350-359
Animal models are frequently used in drug discovery because they represent a mammalian in vivo model system, they are the closest approximation to the human brain, and experimentation in humans is not ethical. Working with postmortem human brain samp
Publikováno v:
The Journal of Prediction Markets. 14:105-125
Business writers and academics have suggested keeping an investing diary to avoid hindsight bias. In the diary, investors justify their predictions of future events, e.g., “This stock will go up because…” Eliminating hindsight bias should impro
Publikováno v:
Critical Perspectives on Accounting. 47:26-38
Although the PCAOB describes the auditor’s report as utilizing a “pass/fail model,” auditing standards provide auditors with a reporting option that is not strictly “pass” or “fail” – a qualified audit opinion. Qualified opinions prov
Autor:
Tom Pryor, Michael Cipriano
Publikováno v:
Journal of Corporate Accounting & Finance. 28:94-97
Publikováno v:
Journal of Accounting Education. 37:13-23
In this role-play case, you will assume the role of an auditor who must gather relevant information about your client and assess inherent risk for six financial statement accounts. To initiate the process of understanding your client's business, you
Autor:
Michael Cipriano
Publikováno v:
Journal of Corporate Accounting & Finance. 27:89-92