Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael Christopher Roy"'
Publikováno v:
Journal of Controlled Release. 134:201-206
A new controlled-release, extrudable core system (ECS) tablet has been developed which osmotically delivers high doses of low solubility active pharmaceutical ingredients (API's). The tablet has a single core formed in a modified oval shape with a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455a2f1412a7c1ba05e2564c8b667a7a
https://doi.org/10.1016/j.jconrel.2008.11.017
https://doi.org/10.1016/j.jconrel.2008.11.017
Autor:
Barbara Alice Johnson, William B. Arikpo, Michael Bruce Fergione, Timothy W. Graul, Michael Christopher Roy, Bruce C. MacDonald, Kenneth Craig Waterman, Robert J. Timpano
Publikováno v:
Journal of Pharmaceutical Sciences. 97:1499-1507
Significant degradation of the amine-based smoking cessation drug varenicline tartrate in an early development phase osmotic, controlled-release (CR) formulation yields predominantly two products: N-methylvarenicline (NMV) and N-formylvarenicline (NF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318aeff24524cada1625015e31e7672c
https://doi.org/10.1002/jps.21119
https://doi.org/10.1002/jps.21119
Autor:
Bruce C. MacDonald, Patrick Lukulay, Anthony J. Carella, Michael Christopher Roy, Michael J. Gumkowski, Sheri L. Shamblin, Kenneth Craig Waterman
Publikováno v:
Pharmaceutical Research. 24:780-790
To propose and test a new accelerated aging protocol for solid-state, small molecule pharmaceuticals which provides faster predictions for drug substance and drug product shelf-life. The concept of an isoconversion paradigm, where times in different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0370d331a1d64ffea37402460cb2ed
https://doi.org/10.1007/s11095-006-9201-4
https://doi.org/10.1007/s11095-006-9201-4
Publikováno v:
Pharmaceutical Development and Technology. 7:227-234
A case study is described where degradation of a solid pharmaceutical dosage form susceptible to oxidation is minimized by incorporation of an oxygen scavenger as part of the packaging. Extremely low oxygen levels are attainable within 24 hr of packa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a726dc91016f13ef614e56f5bb8f6cc
https://doi.org/10.1081/pdt-120003490
https://doi.org/10.1081/pdt-120003490