Zobrazeno 1 - 10
of 882
pro vyhledávání: '"Michael Chen"'
Autor:
Brenton P. Munson, Michael Chen, Audrey Bogosian, Jason F. Kreisberg, Katherine Licon, Ruben Abagyan, Brent M. Kuenzi, Trey Ideker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polypharmacology drugs—compounds that inhibit multiple proteins—have many applications but are difficult to design. To address this challenge we have developed POLYGON, an approach to polypharmacology based on generative reinforcement le
Externí odkaz:
https://doaj.org/article/55b169129e9145c5abf476bbec8ac7f5
Autor:
Lars Erik Kristensen, Mauro Keiserman, Kim Papp, Leslie McCasland, Douglas White, Kyle Carter, Ralph Lippe, Huzefa Photowala, Leonidas Drogaris, Ahmed M. Soliman, Michael Chen, Byron Padilla, Frank Behrens
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 3, Pp 617-632 (2024)
Abstract Introduction Patients with psoriatic arthritis (PsA) require treatment providing durable long-term efficacy in different disease domains as well as safety. We present 100-week efficacy and safety results of risankizumab in patients with acti
Externí odkaz:
https://doaj.org/article/d175f505a9724186801cfc38fbee94d1
Publikováno v:
Patterns, Vol 5, Iss 5, Pp 100988- (2024)
Summary: This paper argues that a range of current AI systems have learned how to deceive humans. We define deception as the systematic inducement of false beliefs in the pursuit of some outcome other than the truth. We first survey empirical example
Externí odkaz:
https://doaj.org/article/b399a1ee3f144386ad541137a947a42e
Autor:
Eman Soliman, John Leonard, Erwin Kristobal Gudenschwager Basso, Ilana Gershenson, Jing Ju, Jatia Mills, Caroline de Jager, Alexandra M. Kaloss, Mohamed Elhassanny, Daniela Pereira, Michael Chen, Xia Wang, Michelle H. Theus
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation, prevents the release of inflammatory molecules, and promotes the production of anti-inflammatory c
Externí odkaz:
https://doaj.org/article/9af10e8dd4b0412e9b14f181068792d0
Autor:
J.B. Collins, Skyler A. Stone, Emily J. Koury, Anna G. Paredes, Fiona Shao, Crystal Lovato, Michael Chen, Richelle Shi, Anwyn Y. Li, Isa Candal, Khadija Al Moutaa, Nicolas D. Moya, Erik C. Andersen
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100556- (2024)
Benzimidazole (BZ) anthelmintics are among the most important treatments for parasitic nematode infections in the developing world. Widespread BZ resistance in veterinary parasites and emerging resistance in human parasites raise major concerns for t
Externí odkaz:
https://doaj.org/article/a2b854f4d1dc4ffc83d524e4f4ba01c6
Autor:
Andrea M. Cappellano, Natalia Dassi, Bruna M. Mançano, Sidnei Epelman, Daniela B. Almeida, Sergio Cavalheiro, Patricia A. Dastoli, Maria T. S. Alves, Jardel M. Nicacio, Marcos D. S. Costa, Frederico A. Silva, Simone S. Aguiar, Maria L. Figueiredo, Michael Chen, Nasjla S. Silva, Jonathan L. Finlay
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundNon-germinomatous germ cell tumors (NGGCT) accounts for one third of intracranial GCT. While the germinoma group have an excellent overall survival, the standard of practice for children with NGGCT is still under evaluation.AimsDescribe the
Externí odkaz:
https://doaj.org/article/3323d3b79fc54705bea05e4f45b07baf
Autor:
Irina AD Mancini, Riccardo Levato, Marlena M Ksiezarczyk, Miguel Dias Castilho, Michael Chen, Mattie HP van Rijen, Lonneke L IJsseldijk, Marja Kik, P René van Weeren, Jos Malda
Publikováno v:
eLife, Vol 12 (2023)
During evolution, animals have returned from land to water, adapting with morphological modifications to life in an aquatic environment. We compared the osteochondral units of the humeral head of marine and terrestrial mammals across species spanning
Externí odkaz:
https://doaj.org/article/f1037f5779dc467081edf3994cc0a981
Autor:
Yi-Jou Chen, Michael Chen, Tian-Lu Cheng, Yi-Shan Tsai, Chang-Hung Wang, Che-Yi Chen, Tung-Yun Wu, Shey-Cherng Tzou, Kai-Hung Wang, Jing-Jy Cheng, An-Pei Kao, Shyr-Yi Lin, Kuo-Hsiang Chuang
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-19 (2023)
Abstract Background Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. However, the commercial production of cancer-specific T cells is often hampered by laborious cell culture procedures, the
Externí odkaz:
https://doaj.org/article/3306fd61a6ee4e49b2484aa0cb693348
Autor:
Tung-Yun Wu, Michael Chen, I-Chung Chen, Yi-Jou Chen, Che-Yi Chen, Chang-Hung Wang, Jing-Jy Cheng, Kunal Nepali, Kuo-Hsiang Chuang, Jing-Ping Liou
Publikováno v:
Journal of Advanced Research, Vol 46, Iss , Pp 159-171 (2023)
Introduction: The tumor microenvironment is mainly flooded with immunosuppressive cells and inhibitory cytokines, resulting in the inability of effective immune cells to infiltrate and recognize tumors and even the loss of anti-cancer ability. Object
Externí odkaz:
https://doaj.org/article/4903448c207a4dc1a947c930d7bfde46
Autor:
Toby J. L. Humphrey, Davinder Dosanjh, Thomas F. Hiemstra, Alex Richter, Michael Chen-Xu, Wendi Qian, Vivekanand Jha, Katrina Gatley, Rakshya Adhikari, Francis Dowling, Rona M. Smith
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Despite the introduction of vaccination, there remains a need for pre-exposure prophylactic agents against SARS-CoV-2. Several patient groups are more vulnerable to SARS-CoV-2 infection by virtue of underlying health conditions, t
Externí odkaz:
https://doaj.org/article/e71cf786e7784cfa94add1ac3ed0b268