Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michael Charles Nyman"'
Autor:
Thomas J. Stout, Brett B. Busch, Todd G. Kirchgessner, Michael Charles Nyman, Tie-Lin Wang, Ruth R. Wexler, Lam Nguyen, Ellen K. Kick, Brandee L. Wagner, Grace Yan, Yinong Xie, Edwin J. Schweiger, Artur Plonowski, Ira G. Schulman, Brenton T. Flatt, Jacek Ostrowski, Max H. Nanao, Richard Martin, Raju Mohan, Xiao-Hui Gu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:372-377
A series of biaryl pyrazole and imidazole Liver X Receptor (LXR) partial agonists has been synthesized displaying LXRβ selectivity. The LXRβ selective partial agonist 18 was identified with potent induction of ATP binding transporters ABCA1 and ABC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7244efc41c2284fe9a58be668b38fd90
https://doi.org/10.1016/j.bmcl.2014.11.029
https://doi.org/10.1016/j.bmcl.2014.11.029
Autor:
William C. Stevens, John A. Lupisella, Venkataiah Bollu, Richard Martin, Denise Grimm, Rangaraj Narayanan, Max H. Nanao, Ruth R. Wexler, Raju Mohan, Xiaoping Hou, Meriah Neissel Valente, Brant Clayton Boren, Grace Yan, James Smalley, Brett B. Busch, Jacek Ostrowski, Paul G. Sleph, Yinong Xie, Barry Brock, Ira G. Schulman, A. David Rodrigues, Artur Plonowski, Glenn H. Cantor, Michael Charles Nyman, Huiping Zhang, Lam Nguyen, Ellen K. Kick, Todd G. Kirchgessner, Kamelia Behnia
Publikováno v:
ACS medicinal chemistry letters. 7(12)
Introducing a uniquely substituted phenyl sulfone into a series of biphenyl imidazole liver X receptor (LXR) agonists afforded a dramatic potency improvement for induction of ATP binding cassette transporters, ABCA1 and ABCG1, in human whole blood. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7f03cc7bbe62de8dff6d1806159952
https://pubmed.ncbi.nlm.nih.gov/27994765
https://pubmed.ncbi.nlm.nih.gov/27994765
Autor:
Katherine B. Louie, Wolfgang Reindl, Kai Deng, Matthew P. Greving, Anup K. Singh, Michael Charles Nyman, Blake A. Simmons, Xiaoliang Cheng, Gary Siuzdak, Joseph Cohen, Benjamin P. Bowen, Paul D. Adams, Trent R. Northen
Publikováno v:
Analytical and bioanalytical chemistry. 403(3)
Mass spectrometry (MS)-based enzyme assay has been shown to be a useful tool for screening enzymatic activities from environmental samples. Recently, reported approaches for high-specificity multiplexed characterization of enzymatic activities allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e677e126a083334a2628b5d1b3be96ac
https://pubmed.ncbi.nlm.nih.gov/22407334
https://pubmed.ncbi.nlm.nih.gov/22407334