Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael Cangkrama"'
Autor:
Selina Gurri, Beat Siegenthaler, Michael Cangkrama, Gaetana Restivo, Marcel Huber, James Saliba, Reinhard Dummer, Volker Blank, Daniel Hohl, Sabine Werner
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-22 (2023)
Abstract Epithelial skin cancers are extremely common, but the mechanisms underlying their malignant progression are still poorly defined. Here, we identify the NRF3 transcription factor as a tumor suppressor in the skin. NRF3 protein expression is s
Externí odkaz:
https://doaj.org/article/70d51ab9fc7b4691a8599527533a94b1
Autor:
Laura Yerly, Christine Pich-Bavastro, Jeremy Di Domizio, Tania Wyss, Stéphanie Tissot-Renaud, Michael Cangkrama, Michel Gilliet, Sabine Werner, François Kuonen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The role of reciprocal tumour-stroma interactions in tumour invasion remains poorly characterised. Here, single-cell and spatial transcriptomics identifies the cell populations and their transcriptional reprogramming contributing to the spatial organ
Externí odkaz:
https://doaj.org/article/ea3f55ef4f1f4bc89b960a13a7cc8b39
Autor:
Mateusz S. Wietecha, Marco Pensalfini, Michael Cangkrama, Bettina Müller, Juyoung Jin, Jürgen Brinckmann, Edoardo Mazza, Sabine Werner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
The relationship between histopathology, gene expression, and biochemical and mechanical properties of wounds is largely unknown. Here, the authors show that activin A alters wound healing at multiple levels by promoting pro-fibrotic gene expression
Externí odkaz:
https://doaj.org/article/2e66745780404598b2279a929056766b
Autor:
Michael Cangkrama, Mateusz Wietecha, Nicolas Mathis, Rin Okumura, Luca Ferrarese, Dunja Al‐Nuaimi, Maria Antsiferova, Reinhard Dummer, Metello Innocenti, Sabine Werner
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-21 (2020)
Abstract Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs. Mechanis
Externí odkaz:
https://doaj.org/article/7e9880af155f4dfe920e625f78f674f9
Autor:
Maria Antsiferova, Aleksandra Piwko‐Czuchra, Michael Cangkrama, Mateusz Wietecha, Dilara Sahin, Katharina Birkner, Valerie C Amann, Mitchell Levesque, Daniel Hohl, Reinhard Dummer, Sabine Werner
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 1, Pp 27-45 (2016)
Abstract Activin has emerged as an important player in different types of cancer, but the underlying mechanisms are largely unknown. We show here that activin overexpression is an early event in murine and human skin tumorigenesis. This is functional
Externí odkaz:
https://doaj.org/article/8b489d48e3b74bdda947d60c4b576bef
Autor:
Mateusz S. Wietecha, David Lauenstein, Michael Cangkrama, Sybille Seiler, Juyoung Jin, Andreas Goppelt, Manfred Claassen, Mitchell P. Levesque, Reinhard Dummer, Sabine Werner
Publikováno v:
Matrix Biology, 119
Healing wounds and cancers present remarkable cellular and molecular parallels, but the specific roles of the healing phases are largely unknown. We developed a bioinformatics pipeline to identify genes and pathways that define distinct phases across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4176bf0c273fa02d39c8c02f75c9c7f0
https://doi.org/10.1016/j.matbio.2023.03.003
https://doi.org/10.1016/j.matbio.2023.03.003
Autor:
Sabine Werner, Metello Innocenti, Manfred Kopf, Michela Di Filippo, Mai Matsushita, Maria Zubair, James Whipman, Huan Liu, Michael Cangkrama
Cancer-associated fibroblasts (CAF) are key regulators of tumorigenesis. Further insights into the tumor-promoting mechanisms of action of CAFs could help improve cancer diagnosis and treatment. Here we show that the formin mDia2 regulates the positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fb9aca56dc9e18585127273076dc8a8
https://doi.org/10.1158/0008-5472.c.6514113.v1
https://doi.org/10.1158/0008-5472.c.6514113.v1
Autor:
Sabine Werner, Metello Innocenti, Manfred Kopf, Michela Di Filippo, Mai Matsushita, Maria Zubair, James Whipman, Huan Liu, Michael Cangkrama
Supplementary Figure from A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333d96333ce849407e4ee95162deee69
https://doi.org/10.1158/0008-5472.22432308.v1
https://doi.org/10.1158/0008-5472.22432308.v1
Autor:
Sabine Werner, Metello Innocenti, Manfred Kopf, Michela Di Filippo, Mai Matsushita, Maria Zubair, James Whipman, Huan Liu, Michael Cangkrama
Supplementary Data from A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f615953c0eac3dae77e9d271b7f0406
https://doi.org/10.1158/0008-5472.22432311
https://doi.org/10.1158/0008-5472.22432311
Autor:
Francois Kuonen, Sabine Werner, Michel Gilliet, Michael Cangkrama, Stéphanie Tissot, Tania Wyss, Jeremy Di Domizio, Christine Pich-Bavastro, Laura Yerly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc18c0170e93da62ceed3e9d5662407e
https://doi.org/10.26226/m.62fa00a04b6034001b1c3152
https://doi.org/10.26226/m.62fa00a04b6034001b1c3152